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Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition.|Product information|CAS Number: 1071517-39-9|Molecular Weight: 560.62|Formula: C25H25FN4O6S2|Chemical Name: N-{3-[(1R,2S,7R,8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo[6.2.1.0²,⁷]undec-5-en-5-yl]-1,1-dioxo-4H-1λ⁶,2,4-benzothiadiazin-7-yl}methanesulfonamide|Smiles: CS(=O)(=O)NC1=CC2=C(C=C1)NC(=NS2(=O)=O)C1=C(O)[C@H]2[C@H]([C@H]3C[C@@H]2CC3)N(CC2C=CC(F)=CC=2)C1=O|InChiKey: DEKOYVOWOVJMPM-RLHIPHHXSA-N|InChi: InChI=1S/C25H25FN4O6S2/c1-37(33,34)28-17-8-9-18-19(11-17)38(35,36)29-24(27-18)21-23(31)20-14-4-5-15(10-14)22(20)30(25(21)32)12-13-2-6-16(26)7-3-13/h2-3,6-9,11,14-15,20,22,28,31H,4-5,10,12H2,1H3,(H,27,29)/t14-,15+,20+,22-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tafasitamab} site|{Tafasitamab} Apoptosis|{Tafasitamab} Technical Information|{Tafasitamab} Formula|{Tafasitamab} manufacturer|{Tafasitamab} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:33314897 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors.|Products are for research use only. Not for human use.|

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Propargyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 2086689-09-8|Molecular Weight: 230.26|Formula: C11H18O5|Chemical Name: methyl 3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanoate|Smiles: COC(=O)CCOCCOCCOCC#C|InChiKey: SDSYWBQIDUXXIQ-UHFFFAOYSA-N|InChi: InChI=1S/C11H18O5/c1-3-5-14-7-9-16-10-8-15-6-4-11(12)13-2/h1H,4-10H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Balovaptan} medchemexpress|{Balovaptan} GPCR/G Protein|{Balovaptan} Technical Information|{Balovaptan} Data Sheet|{Balovaptan} custom synthesis|{Balovaptan} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:26446225 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin.|Product information|CAS Number: 82189-04-6|Molecular Weight: 638.79|Formula: C36H50N2O8|Chemical Name: 15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl 2-(cyclohexylformamido)propanoate|Smiles: CC1=CCCC2=CC(O)=CC(NC(=O)CC(C=CC=CC=CCC(OC(=O)C(C)NC(=O)C3CCCCC3)C(C)C1O)OC)=C2O|InChiKey: VVJDHJZQBGWPEQ-QFUIHVKNSA-N|InChi: InChI=1S/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5-,12-7-,18-11-,23-14-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Aldosterone} medchemexpress|{Aldosterone} Endogenous Metabolite|{Aldosterone} Purity & Documentation|{Aldosterone} Description|{Aldosterone} manufacturer|{Aldosterone} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.{{Tropicamide} medchemexpress|{Tropicamide} mAChR|{Tropicamide} Technical Information|{Tropicamide} References|{Tropicamide} custom synthesis|{Tropicamide} Epigenetic Reader Domain} 5 μg/ml, 12.PMID:27217159 5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively. Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM. Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM.|In Vivo:|Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice.|Products are for research use only. Not for human use.|

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Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant. Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine . Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048 . Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480 . West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932 . Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554|Product information|CAS Number: 24939-03-5|Molecular Weight: 671.40|Formula: C19H27N7O16P2|Chemical Name: {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid; {[(2R,3S,4S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid|Smiles: NC1C=CN([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]2O)C(=O)N=1.OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1NC=NC2=O|InChiKey: ACEVNMQDUCOKHT-YJZUVTEISA-N|InChi: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7+,8-/m11/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication. It is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with IC50 values as low as 20 nM. However, UK 1 is devoid of antimicrobial activity and is inactive against Pseudomonas aeruginosa and Staphylococcus aureus, a methicillin-resistant strain of S. aureus. Additionally, UK-1 can bind a wide variety of di- and tri-valent metal ions, particularly Mg2+ ions, and form complexes with DNA in the presence of Mg2+ ions. Topo II are ATP-dependent enzymes, which can simultaneously cut both strands of the DNA helix to manage DNA supercoils and tangles. In vitro: UK 1 strongly blocked the growth of human epitheloid carcinoma HeLa, mouse melanoma B16, mouse leukemia P388 cells with ED50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.{{Frexalimab} web|{Frexalimab} Apoptosis|{Frexalimab} Purity & Documentation|{Frexalimab} References|{Frexalimab} manufacturer|{Frexalimab} Epigenetic Reader Domain} 11 μg/ml, respectively.{{Tezepelumab (anti-TSLP)} site|{Tezepelumab (anti-TSLP)} Protocol|{Tezepelumab (anti-TSLP)} In Vitro|{Tezepelumab (anti-TSLP)} manufacturer|{Tezepelumab (anti-TSLP)} Autophagy} UK 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml .PMID:23910527 In vivo: Up to now, in vivo study of UK 1 is still in the development stage.|Product information|CAS Number: 151271-53-3|Molecular Weight: 386.36|Formula: C22H14N2O5|Chemical Name: methyl 2-[2-(2-hydroxyphenyl)-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate|Smiles: COC(=O)C1=CC=CC2OC(=NC=21)C1=CC=CC2OC(=NC=21)C1=CC=CC=C1O|InChiKey: NGKIDJMAXLRJRL-UHFFFAOYSA-N|InChi: InChI=1S/C22H14N2O5/c1-27-22(26)14-8-5-11-17-19(14)24-21(29-17)13-7-4-10-16-18(13)23-20(28-16)12-6-2-3-9-15(12)25/h2-11,25H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2,4-Diacetylphloroglucinol is an agent against various plant pathogenic fungi, viruses, bacteria, and nematodes. 2,4-Diacetylphloroglucinol, a non-nitrogen-containing compound produced by some isolates of P. fluorescens, has been used to increase crop yield by controlling plant root diseases. In vitro: A previous study was conducted to determine if 2,4-diacetylphloroglucinol was toxic to selected nematodes. The plant-parasitic nematodes including Pratylenchus scribneri and Xiphinema americanum, Heterodera glycines, Meloidogyne incognita, and the bacterial-feeding nematodes such as Pristionchus pacificus, Caenorhabditis elegans, and Rhabditis rainai, were found to be immersed in concentrations ranging from 0 to 100 μg/ml of 2,4-diacetylphloroglucinol. Moreove, the egg hatch and viability of juveniles and adults were determined, and the results showed that 2,4-diacetylphloroglucinol was toxic to X. americanum adults with an LD50 of 8.3 μg/ml. 2,4-Diacetylphloroglucinol could decrease M. incognita egg hatch, but stimulated C. elegans hatch. Whereas, the viability of M. incognita J2 and of C. elegans J1 and adults was not affected. There were no observed effects on the other nematodes. These findings indicated that 2,4-diacetylphloroglucinol was not toxic to all nematodes, and did not affect the tested species of beneficial bacterial-feeding nematodes . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 2161-86-6|Molecular Weight: 210.18|Formula: C10H10O5|Chemical Name: 1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-1-one|Smiles: CC(=O)C1C(O)=CC(O)=C(C=1O)C(C)=O|InChiKey: PIFFQYJYNWXNGE-UHFFFAOYSA-N|InChi: InChI=1S/C10H10O5/c1-4(11)8-6(13)3-7(14)9(5(2)12)10(8)15/h3,13-15H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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CGP 13501 is a positive allosteric modulator of GABAB receptor . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel.{{Nicorandil} web|{Nicorandil} Potassium Channel|{Nicorandil} Technical Information|{Nicorandil} In Vitro|{Nicorandil} supplier|{Nicorandil} Autophagy} It stimulates the opening of K+ channel and hyperpolarize the neuron.PMID:23539298 CGP 13501 is a positive allosteric modulator of GABAB receptor. In Chinese hamster ovary (CHO) cell line expressing GABAB(1b/2), CGP 13501 potentiated GABA-stimulated GTPγ[35S] binding to cell membranes . In rat cortex, CGP13501 (10 μM) enhanced GABA-mediated activation of Gαo and increased GTPγ[35S] binding in the presence of GABA. Also, in the hippocampus and cerebellum, CGP13501 increased GABA-induced GTPγ[35S] binding and activation of Gαo. In rat cortex, hippocampus and cerebellum, CGP55845A blocked the influence of CGP13501 on GABA-induced GTPγ[35S] binding at Gαo with pIC50 values of 7.4, 7.31 and 6.82, respectively. In cells expressing GABAB(1b+2) receptors, CGP13501 increased GTPγ[35S] binding at Gαi1/3 .|Product information|CAS Number: 56189-68-5|Molecular Weight: 290.44|Formula: C19H30O2|Chemical Name: 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal|Smiles: CC(C)(C)C1=CC(CC(C)(C)C=O)=CC(=C1O)C(C)(C)C|InChiKey: XGWATTXMMMANFJ-UHFFFAOYSA-N|InChi: InChI=1S/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|