PI-273

PI-273

Product Name :
PI-273

Description:
PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.

CAS:
925069-34-7

Molecular Weight:
381.90

Formula:
C16H16ClN3O2S2

Chemical Name:
2-({[(4-chlorophenyl)formamido]methanethioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide

Smiles :
CC1SC(NC(=S)NC(=O)C2C=CC(Cl)=CC=2)=C(C=1CC)C(N)=O

InChiKey:
MIERMBQDBLFAFW-UHFFFAOYSA-N

InChi :
InChI=1S/C16H16ClN3O2S2/c1-3-11-8(2)24-15(12(11)13(18)21)20-16(23)19-14(22)9-4-6-10(17)7-5-9/h4-7H,3H2,1-2H3,(H2,18,21)(H2,19,20,22,23)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{6α-Methylprednisolone 21-hemisuccinate sodium salt} site|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Glucocorticoid Receptor|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Biological Activity|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Data Sheet|{6α-Methylprednisolone 21-hemisuccinate sodium salt} manufacturer|{6α-Methylprednisolone 21-hemisuccinate sodium salt} Epigenetics}

Shelf Life:
≥360 days if stored properly.{{Osthole} site|{Osthole} Histamine Receptor|{Osthole} Technical Information|{Osthole} Formula|{Osthole} manufacturer|{Osthole} Cancer}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.|Product information|CAS Number: 925069-34-7|Molecular Weight: 381.90|Formula: C16H16ClN3O2S2|Chemical Name: 2-({[(4-chlorophenyl)formamido]methanethioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide|Smiles: CC1SC(NC(=S)NC(=O)C2C=CC(Cl)=CC=2)=C(C=1CC)C(N)=O|InChiKey: MIERMBQDBLFAFW-UHFFFAOYSA-N|InChi: InChI=1S/C16H16ClN3O2S2/c1-3-11-8(2)24-15(12(11)13(18)21)20-16(23)19-14(22)9-4-6-10(17)7-5-9/h4-7H,3H2,1-2H3,(H2,18,21)(H2,19,20,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 6.PMID:32538180 02 mg/mL (15.76 mM; ultrasonic and warming and heat to 60°C)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PI-273 (2 μM; 48 hours) blocks the cell cycle at the G2-M phase. PI-273 (2 μM; 48 hours) induces cell apoptosis in all three Ras wild-type breast cancer cells: MCF-7, T-47D, and SK-BR-3. PI-273 (0.5-2 μM; for 3 days) can suppress the AKT signaling pathway in a dose- and time-dependent manner. PI-273 of 1 μM and 2 μM inhibits the cell proliferation of both MCF-7 and T-47D cells in a time-dependent manner.|In Vivo:|PI-273 (intraperitoneal injection; 25 mg/kg/day; 15 days) profoundly suppresses the tumor volume and weight in the MCF-7 xenografts. PI-273 (0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically); 0.08-5 hours) has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%.|References:|Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.Products are for research use only. Not for human use.|

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