Archives January 2025

Dynarrestin

Product Name :
Dynarrestin

Description:
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.

CAS:
2222768-84-3

Molecular Weight:
431.50

Formula:
C22H23F2N3O2S

Chemical Name:
ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate

Smiles :
CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC

InChiKey:
UZNNDDDSGCMQOQ-UHFFFAOYSA-N

InChi :
InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Larotrectinib} MedChemExpress|{Larotrectinib} Trk Receptor|{Larotrectinib} Purity & Documentation|{Larotrectinib} In Vitro|{Larotrectinib} supplier|{Larotrectinib} Autophagy}

Shelf Life:
≥12 months if stored properly.{{RGB-1} site|{RGB-1} Epigenetics|{RGB-1} Technical Information|{RGB-1} In Vitro|{RGB-1} manufacturer}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23522542

Additional information:
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.|Product information|CAS Number: 2222768-84-3|Molecular Weight: 431.50|Formula: C22H23F2N3O2S|Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate|Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC|InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

SNIPER(ER)-110

Product Name :
SNIPER(ER)-110

Description:
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.

CAS:
2241690-03-7

Molecular Weight:
1122.39

Formula:
C66H83N5O11

Chemical Name:
(2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide

Smiles :
CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1

InChiKey:
DXLPZZKVYXMXOP-UXACQRMVSA-N

InChi :
InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Bintrafusp alfa} web|{Bintrafusp alfa} TGF-β Receptor|{Bintrafusp alfa} Biological Activity|{Bintrafusp alfa} In stock|{Bintrafusp alfa} manufacturer|{Bintrafusp alfa} Cancer}

Additional information:
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker.{{Sulfapyridine} MedChemExpress|{Sulfapyridine} Antibiotic|{Sulfapyridine} Biological Activity|{Sulfapyridine} Data Sheet|{Sulfapyridine} supplier|{Sulfapyridine} Epigenetics} SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of Product information|CAS Number: 2241690-03-7|Molecular Weight: 1122.PMID:23892746 39|Formula: C66H83N5O11|Chemical Name: (2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide|Smiles: CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1|InChiKey: DXLPZZKVYXMXOP-UXACQRMVSA-N|InChi: InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Creatinine-D3

Product Name :
Creatinine-D3

Description:
Creatinine-D3 (NSC13123-D3) is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.

CAS:
143827-20-7

Molecular Weight:
116.14

Formula:
C4H7N3O

Chemical Name:
2-amino-1-(²H₃)methyl-4,5-dihydro-1H-imidazol-4-one

Smiles :
[2H]C([2H])([2H])N1CC(=O)N=C1N

InChiKey:
DDRJAANPRJIHGJ-FIBGUPNXSA-N

InChi :
InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/i1D3

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{GMP EGF Protein, Human} web|{GMP EGF Protein, Human} Protocol|{GMP EGF Protein, Human} In Vivo|{GMP EGF Protein, Human} manufacturer|{GMP EGF Protein, Human} Autophagy}

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Creatinine-D3 (NSC13123-D3) is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.|Product information|CAS Number: 143827-20-7|Molecular Weight: 116.14|Formula: C4H7N3O|Chemical Name: 2-amino-1-(²H₃)methyl-4,5-dihydro-1H-imidazol-4-one|Smiles: [2H]C([2H])([2H])N1CC(=O)N=C1N|InChiKey: DDRJAANPRJIHGJ-FIBGUPNXSA-N|InChi: InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} MedChemExpress|{Rucaparib} Cell Cycle/DNA Damage|{Rucaparib} Protocol|{Rucaparib} Data Sheet|{Rucaparib} custom synthesis|{Rucaparib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23558135 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Cd(II) protoporphyrin IX

Product Name :
Cd(II) protoporphyrin IX

Description:
Cd(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.

CAS:
80216-25-7

Molecular Weight:
673.05

Formula:
C34H32CdN4O4

Chemical Name:
10,14-bis(2-carboxyethyl)-4,19-diethenyl-5,9,15,20-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),2,4,6,8,10,12,14,16,18-decaene-21,22,23,24-tetraide cadmium

Smiles :
[Cd].CC1C(C=C)=C2C=C3[N-]C(=CC4[N-]C(C=C5[N-]C(=CC=1[N-]2)C(C=C)=C5C)=C(C)C=4CCC(O)=O)C(CCC(O)=O)=C3C |c:6,9,14,17|

InChiKey:
MPXUUHBENXDJJI-RGGAHWMASA-N

InChi :
InChI=1S/C34H32N4O4.Cd/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Cd(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.|Product information|CAS Number: 80216-25-7|Molecular Weight: 673.05|Formula: C34H32CdN4O4|Chemical Name: 10,14-bis(2-carboxyethyl)-4,19-diethenyl-5,9,15,20-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),2,4,6,8,10,12,14,16,18-decaene-21,22,23,24-tetraide cadmium|Smiles: [Cd].CC1C(C=C)=C2C=C3[N-]C(=CC4[N-]C(C=C5[N-]C(=CC=1[N-]2)C(C=C)=C5C)=C(C)C=4CCC(O)=O)C(CCC(O)=O)=C3C |c:6,9,14,17||InChiKey: MPXUUHBENXDJJI-RGGAHWMASA-N|InChi: InChI=1S/C34H32N4O4.{{Purmorphamine} medchemexpress|{Purmorphamine} Smo|{Purmorphamine} Epigenetics|{Purmorphamine} Technical Information|{Purmorphamine} In Vitro|{Purmorphamine} supplier} Cd/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Afatinib dimaleate} site|{Afatinib dimaleate} Apoptosis|{Afatinib dimaleate} Immunology/Inflammation|{Afatinib dimaleate} Technical Information|{Afatinib dimaleate} Formula|{Afatinib dimaleate} custom synthesis} |Shelf Life: ≥12 months if stored properly.PMID:25046520 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com