Additional information:
Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively. Naftopidil dihydrochloride has antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia.|Product information|CAS Number: 57149-08-3|Molecular Weight: 465.41|Formula: C24H30Cl2N2O3|Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol dihydrochloride|Smiles: Cl.Cl.COC1=CC=CC=C1N1CCN(CC(O)COC2=CC=CC3=CC=CC=C32)CC1|InChiKey: HZVCEQMJXMUXJF-UHFFFAOYSA-N|InChi: InChI=1S/C24H28N2O3.{{Miconazole} medchemexpress|{Miconazole} Antibiotic|{Miconazole} Protocol|{Miconazole} Purity|{Miconazole} supplier|{Miconazole} Autophagy} 2ClH/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Daratumumab} site|{Daratumumab} CD38|{Daratumumab} Protocol|{Daratumumab} Formula|{Daratumumab} supplier|{Daratumumab} Cancer} |Shelf Life: ≥12 months if stored properly.PMID:25016614 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Naftopidil dihydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC. Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.|In Vivo:|Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model.|Products are for research use only. Not for human use.|