Additional information:
TNP-351 is an antifolate.{{BMP-4 Protein, Human} web|{BMP-4 Protein, Human} Technical Information|{BMP-4 Protein, Human} Description|{BMP-4 Protein, Human} custom synthesis|{BMP-4 Protein, Human} Autophagy} TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo.{{Gimeracil} web|{Gimeracil} Purity & Documentation|{Gimeracil} In stock|{Gimeracil} custom synthesis|{Gimeracil} Autophagy} |Product information|CAS Number: 125991-51-7|Molecular Weight: 440.45|Formula: C21H24N6O5|Chemical Name: (2S)-2-{[4-(3-{2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl}propyl)phenyl]formamido}pentanedioic acid|Smiles: NC1N=C(N)C2=C(NC=C2CCCC2C=CC(=CC=2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N=1|InChiKey: WLGCEMWNUHSIIS-AWEZNQCLSA-N|InChi: InChI=1S/C21H24N6O5/c22-17-16-13(10-24-18(16)27-21(23)26-17)3-1-2-11-4-6-12(7-5-11)19(30)25-14(20(31)32)8-9-15(28)29/h4-7,10,14H,1-3,8-9H2,(H,25,30)(H,28,29)(H,31,32)(H5,22,23,24,26,27)/t14-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24733396 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively. The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively.|Products are for research use only. Not for human use.|