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Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding.{{Anti-Mouse IL-1b Antibody} web|{Anti-Mouse IL-1b Antibody} Interleukin Related|{Anti-Mouse IL-1b Antibody} Protocol|{Anti-Mouse IL-1b Antibody} References|{Anti-Mouse IL-1b Antibody} custom synthesis|{Anti-Mouse IL-1b Antibody} Epigenetics} Fibrin is the major component of the blood clot and is used for coagulation.PMID:25429455 |Product information|CAS Number: 9001-31-4|Molecular Weight: 145.16|Formula: C5H11N3O2|Chemical Name: 2-amino-N-[(methylcarbamoyl)methyl]acetamide|Smiles: CNC(=O)CNC(=O)CN|InChiKey: BWGVNKXGVNDBDI-UHFFFAOYSA-N|InChi: InChI=1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor. Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain. In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor.{{Olanzapine} MedChemExpress|{Olanzapine} Autophagy|{Olanzapine} Purity & Documentation|{Olanzapine} Data Sheet|{Olanzapine} supplier|{Olanzapine} Epigenetics} Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring.{{Treosulfan} site|{Treosulfan} DNA Alkylator/Crosslinker|{Treosulfan} Technical Information|{Treosulfan} Purity|{Treosulfan} manufacturer|{Treosulfan} Epigenetics} In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially .PMID:23290930 In vivo: So far, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 57-71-6|Molecular Weight: 101.10|Formula: C4H7NO2|Chemical Name: (3E)-3-(hydroxyimino)butan-2-one|Smiles: C/C(=N\O)/C(C)=O|InChiKey: FSEUPUDHEBLWJY-HWKANZROSA-N|InChi: InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 20813-76-7|Molecular Weight: 536.{{Tazarotene} MedChemExpress|{Tazarotene} Autophagy|{Tazarotene} Biological Activity|{Tazarotene} In Vitro|{Tazarotene} supplier|{Tazarotene} Epigenetics} 29|Formula: C10H27N4Na2O16P|Chemical Name: disodium octahydrate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate|Smiles: O.{{Ciprofloxacin} medchemexpress|{Ciprofloxacin} Antibiotic|{Ciprofloxacin} Biological Activity|{Ciprofloxacin} Description|{Ciprofloxacin} manufacturer|{Ciprofloxacin} Epigenetics} O.PMID:36014399 O.O.O.O.O.O.[Na+].[Na+].[O-]P([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CNC2=O|InChiKey: QKWLBOYKTJDMLH-NAGQJCCQSA-L|InChi: InChI=1S/C10H13N4O8P.2Na.8H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;;;;;;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;8*1H2/q;2*+1;;;;;;;;/p-2/t4-,6-,7-,10-;;;;;;;;;;/m1………./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 114289-47-3|Molecular Weight: 393.PMID:24278086 56|Formula: C23H39NO4|Chemical Name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide|Smiles: CCCCCCCCCCC(C)(C)C(=O)NC1C(=CC(=CC=1OC)OC)OC|InChiKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N|InChi: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.{{Anti-Mouse IL-1R Antibody} MedChemExpress|{Anti-Mouse IL-1R Antibody} Immunology/Inflammation|{Anti-Mouse IL-1R Antibody} Technical Information|{Anti-Mouse IL-1R Antibody} References|{Anti-Mouse IL-1R Antibody} custom synthesis|{Anti-Mouse IL-1R Antibody} Epigenetic Reader Domain} ,.{{Flucytosine} web|{Flucytosine} Antibiotic|{Flucytosine} Technical Information|{Flucytosine} Description|{Flucytosine} manufacturer|{Flucytosine} Cancer} GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1, an inhibitor of JMJD3.PMID:35991869 GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. Reference: . Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nat.Lett. 449(7163), 731-734 (2011). . Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb.Symp.Quant.Biol. 75, 43-49 (2010). . Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012).|Product information|CAS Number: 1394854-51-3|Molecular Weight: 417.50|Formula: C24H27N5O2|Chemical Name: ethyl 3-{[2-(pyridin-3-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate|Smiles: CCOC(=O)CCNC1=CC(=NC(=N1)C1=CN=CC=C1)N1CCC2=CC=CC=C2CC1|InChiKey: LQPGVGSKBNXQDU-UHFFFAOYSA-N|InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 29331-92-8|Molecular Weight: 254.28|Formula: C15H14N2O2|Chemical Name: (9R)-9-hydroxy-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxamide|Smiles: NC(=O)N1C2=CC=CC=C2C[C@@H](O)C2=CC=CC=C12|InChiKey: BMPDWHIDQYTSHX-CQSZACIVSA-N|InChi: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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A 841720 is a novel non-competitive antagonist of metabotropic glutamate receptor 1 (mGluR1), with an IC50 value of 10.7 nM to 10 µM L-glutamate-induced calcium release at human mGluR1 receptors . Glutamate as the major excitatory neurotransmitter in the central nervous system functions through two types of receptors, ionotropic glutamate receptors and metabotropic glutamate receptors (mGluRs).{{Sirukumab} medchemexpress|{Sirukumab} Interleukin Related|{Sirukumab} Biological Activity|{Sirukumab} Formula|{Sirukumab} supplier|{Sirukumab} Autophagy} MGluRs includes group I mGluRs (mGluR1 and mGluR5 receptors), group II (mGluR2 and mGluR3 receptors) and group III (mGluR4, 6, 7, 8 receptors) .PMID:29844565 In cells, agonist-induced calcium release was concentration-dependently inhibited by A 841720 in a human mGluR5 receptor FLIPR functional assay. But the IC50 value was just 343 nM. In cells expressing recombinant mGluR5 receptors, A 841720 did not block agonist-induced response. In the human mGluR1 receptor FLIPR assay, the log concentration-response curve was shifted by A 841720 at 10 nM to the right. A 841720 at increasing concentrations profoundly reduced the amplitude of L-quisqualate-evoked calcium release. A 841720 at 30 nM reduced the maximal agonist-induced response by 38%. L-quisqualate-induced response was completely abolished by A 841720 at 100 nM . In a water maze test, all rats gradually learned to locate the submerged platform. Treatment with A 841720 significantly slowered rats to find the platform than vehicle control rats. Rats treated with A 841720 at both 30 and 100 µmol/kg doses not only significantly traveled longer distance to find the hidden platform, but also significantly spent longer time to reach the platform .|Product information|CAS Number: 869802-58-4|Molecular Weight: 343.45|Formula: C17H21N5OS|Chemical Name: 5-(azepan-1-yl)-13-(dimethylamino)-8-thia-3,5,10-triazatricyclo[7.4.0.0²,⁷]trideca-1(13),2(7),3,9,11-pentaen-6-one|Smiles: CN(C)C1C=CN=C2SC3C(=O)N(C=NC=3C2=1)N1CCCCCC1|InChiKey: GYWGXEGOXODOQU-UHFFFAOYSA-N|InChi: InChI=1S/C17H21N5OS/c1-20(2)12-7-8-18-16-13(12)14-15(24-16)17(23)22(11-19-14)21-9-5-3-4-6-10-21/h7-8,11H,3-6,9-10H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|