T mdpi/article/10 .3390/genes12101615/s1. The primers for site-directed mutagenesis on the NADSYN1 plasmids are summarized in Supplementary Table S1. Author Contributions: Conceptualization, J.L., L.Z., J.T.Z., Z.W. and N.W.; methodology, J.L. and L.Z.; computer software, S.Z.; validation, J.L., L.Z. and S.L.; formal evaluation, J.L., J.S., N.W., S.Z. and S.L.; investigation, L.Z., Y.N., X.L. and J.L.; sources, S.Z., J.L., Z.C., Z.Z. (Zhengye Zhao), Z.Z. (Zhifa Zheng) and J.T.Z.; data curation, S.Z., J.S., Y.N. and X.L.; writing–original draft preparation, J.L. and L.Z.; writing–review and editing, J.T.Z., Z.W. and N.W.; visualization, S.L.; supervision, J.T.Z., Z.W. and N.W.; project administration, J.T.Z., Z.W. and N.W.; funding acquisition, J.T.Z., Z.W. and N.W. All authors have read and agreed towards the published version of the manuscript. Funding: This analysis was TG6-129 MedChemExpress funded in component by the Beijing All-natural Science Foundation (JQ20032 to N.W., 7191007 to Z.W. and L192015 to J.T.Z.), the National All-natural Science Foundation of China (81802121 to S.L., 81822030 and Desfuroylceftiofur Bacterial 82072391 to N.W., 81930068 and 81772299 to Z.W. and 81672123 and 81972037 to J.T.Z.), Capital’s Funds for Wellness Improvement and Analysis (2020-4-40114 to N.W.), the Tsinghua University-Peking Union Health-related College Hospital Initiative Scientific Analysis Program, Nonprofit Central Investigation Institute Fund of Chinese Academy of Health-related Sciences (No. 2019PT320025). Institutional Assessment Board Statement: The study was authorized by the ethics committee of Peking Union Health-related College Hospital (IRB quantity: JS-908). Informed Consent Statement: Written consent to work with the clinical and genetic data within this report was obtained in the adult individuals and from parents/guardians of all children incorporated in this study. Data Availability Statement: The datasets utilised and/or analyzed throughout the present study are obtainable from the corresponding authors upon affordable request. Acknowledgments: We thank the Nanjing Geneseeq Technologies Inc. for their technical support in sequencing as well as the Ekitech Technologies Inc. for their technical help in database and data management. Conflicts of Interest: There’s no competing interests to declare for all authors.G C A T T A C G G C A TgenesReviewRoles of Glutathione in Mediating Abscisic Acid Signaling and Its Regulation of Seed Dormancy and Drought ToleranceMurali Krishna Koramutla, Manisha Negi and Belay T. Ayele Department of Plant Science, 222 Agriculture Developing, University of Manitoba, Winnipeg, MB R3T 2N2, Canada; [email protected] (M.K.K.); [email protected] (M.N.) Correspondence: [email protected]; Tel.: 1-204-474-8227; Fax: 1-204-474-Citation: Koramutla, M.K.; Negi, M.; Ayele, B.T. Roles of Glutathione in Mediating Abscisic Acid Signaling and Its Regulation of Seed Dormancy and Drought Tolerance. Genes 2021, 12, 1620. 10.3390/ genes12101620 Academic Editors: Sonia Gazzarrini and Eiji Nambara Received: 2 September 2021 Accepted: 13 October 2021 Published: 14 OctoberAbstract: Plant growth and improvement and interactions with the environment are regulated by phytohormones as well as other signaling molecules. In the course of their evolution, plants have developed strategies for efficient signal perception and for the activation of signal transduction cascades to keep proper growth and development, in particular beneath adverse environmental situations. Abscisic acid (ABA) is amongst the phytohormones identified to regulate plant developmental events and.