L count, along with the live sperm price, and elevated the sperm abnormality price. The hematological results obtained within the present study show drastically decreased testosterone levels in rats Propaquizafop Formula treated with paracetamol, indicating that the paracetamol may possibly cause testicular toxicity and impaired fertility. Related outcomes have been obtained by Luangpirom et al. [3] in male mice. This suggests that a high dose of paracetamol (0.05 g/100 g b.wt) induces testicular toxicity. A significant reduction in blood testosterone and impaired seminal quality were identified inside the paracetamol group. An additional study investigated the toxic effects of a high dose of paracetamol on the reproductive program of male rabbits and showed equivalent results to those obtained inside the present study. A significant decrease in blood testosterone and seminal top quality impairment were observed inside the group given high repeated therapeutic doses of paracetamol, which induced several changes and harmfully effected the histological structure on the seminiferous tubules. The study suggests that paracetamol can potentially lead to reproductive toxicity and need to be employed cautiously, specially when higher prolonged doses are indicated [29]. Additionally, the current study shows that paracetamol significantly decreased the erythrocyte (RBC) count, hemoglobin (Hb) content material, and packed cell volume (PCV). This reduce in RBCs and Hb reduces the oxygen-carrying capacity with the RBCs and decreases the level of oxygen reaching the cells, potentially causing anemia and impairing body functions. Related reports show that treating rats with paracetamol decreased the PCV and RBC counts when compared with the controls [4,30]. Eperisone Technical Information Furthermore, the WBC and stab cell counts drastically increased in the paracetamol group compared to the handle and other treatmentBiology 2021, ten,12 ofgroups. The present hematological final results suggest that overdoses and long-term treatment with paracetamol may possibly stimulate the immune system to safeguard the body from infections. The present benefits are consistent using a study published in 2015 [30], which investigated the effect of paracetamol around the hematological parameters in rats. The rats had been given overdoses (300mg) of paracetamol for two days, as well as the results showed considerably elevated WBC counts within the therapy groups when compared with the control group. A polyphenol in EVOO is deemed to exhibit high antioxidant activity [31,32]. Hence, the present study investigated the protective effect of EVOO against paracetamol-induced hematotoxicity and testicular toxicity. The outcomes obtained show amelioration within the paracetamol-with-EVOO group compared with all the paracetamol group. The histological and ultrastructural examination show that most of the seminiferous tubules contained regular spermatogonia, principal spermatocytes, and spermatids. Sertoli cells had flattened nuclei plus the sperm showed elongated condensed nuclei and acrosomal caps in the fronts from the heads. Spermatids appeared to have normal nuclei, and vacuoles were observed in some cells. The EVOO group showed improvements in most of the seminiferous tubules and significantly less prominent histopathological alterations compared to the paracetamol group. This amelioration might be as a result of a polyphenolic component in EVOO in addition to a potential indirect reduction of oxidative stress via gene expression modulation and enzyme activity, which enhances enzymatic antioxidant defenses [16]. A similar report [29] indicated that olive oil features a protective effect against oxi.