was in positive correlation with systolic blood pressure, CRP, triglycerides, serum creatinine and in negative correlation with glomerular filtration rate . Correlations were calculated for bothhypertensive and healthy 481-53-8 cost individuals together. doi:10.1371/journal.pone.0126190.g001 5 / 17 Angiogenesis in Hypertension Fig 2. VEGF concentration in hypertension. Hypertension was associated with increased serum levels of VEGF. The data are presented as medians, 2575% percentiles and minimum–maximum. Statistical significance is marked with “”. Concentration of VEGF was in positive correlation with systolic blood pressure, CRP, serum creatinine and in negative correlation with glomerular filtration rate . Correlations were calculated for both- hypertensive and healthy individuals together.Angiogenesis in Hypertension Fig 3. PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19783706 IL-8 concentration in hypertension. Hypertension was associated with increased serum levels of IL = 8. The data are presented as medians, 2575% percentiles and minimum–maximum. Statistical significance is marked with “”. Concentration of IL = 8 was in positive correlation PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/19786614 with systolic blood pressure and in negative correlation with glomerular filtration rate . Correlations were calculated for both- hypertensive and healthy individuals together. doi:10.1371/journal.pone.0126190.g003 respectively). Serum concentration of theses cytokines was in positive correlation with systolic blood pressure and in negative correlation with glomerular filtration rate . In addition, concentration of endostatin correlated positively with level of C-reactive protein, triglycerides and serum creatinine, while serum VEGF levels were in positive correlation with CRP and serum creatinine concentration. When hypertensive patients were divided into well-controlled and not well-controlled, it was found that individuals who were not well controlled by the therapy- had higher serum levels of VEGF and IL-8, than patients with well-controlled hypertension. 7 / 17 Angiogenesis in Hypertension Fig 4. Control of hypertension and serum concentration of cytokines. Patients with well controlled hypertension had lower serum levels of VEGF and IL = 8 in comparison with individuals with not well-controlled hypertension. The data are presented as medians, 2575% percentiles and minimum–maximum. Statistical significance is marked with “”. doi:10.1371/journal.pone.0126190.g004 Hypertensive patients are characterized by decreased serum levels of angiogenin and bFGF Patients with hypertension had significantly lower serum levels of angiogenin and bFGF than normotensive controls. The same differences were found when the data were re-analyzed in order to express the amount of the cytokine of interest in Fig 5. Angiogenin concentration in hypertension. Patients with hypertension were characterized by lower serum concentration of angiogenin than healthy individuals. The data are presented as medians, 2575% percentiles and minimum–maximum. Statistical significance is marked with “”. doi:10.1371/journal.pone.0126190.g005 8 / 17 Angiogenesis in Hypertension Fig 6. bFGF concentration in hypertension. Patients with hypertension were characterized by lower serum concentration of bFGF than healthy individuals. The data are presented as medians, 2575% percentiles and minimum– maximum. Statistical significance is marked with. Obesity does not affect endostatin, VEGF, IL-8, angiogenin and bFGF levels in serum of hypertensive and healthy individuals As previous studies suggested