O K, Tada H, et al. Structure and chromosomal localization from the human stromal cell-derived aspect 1 gene. Genomics 28: 495500. De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, et al. Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood 103: 24522459. ten. 11. 12. 13. 14. 15. six Mobilization of Stem Cells soon after Stroke 16. Vila-Coro AJ, Rodriguez-Frade JM, Martin De Ana A, Moreno-Ortiz MC, Martinez AC, et al. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 13: 16991710. 17. Reddy K, Zhou Z, Jia SF, Lee TH, Morales-Arias J, et al. Stromal cellderived factor-1 stimulates vasculogenesis and enhances Ewing’s sarcoma tumor growth within the absence of vascular endothelial development factor. Int J Cancer 123: 831837. 18. Juarez J, Bendall L SDF-1 and CXCR4 in typical and malignant hematopoiesis. Histol Histopathol 19: 299309. 19. Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, et al. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 35: 233245. 20. Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 203: 22012213. 21. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A 95: 94489453. 22. Lapidot T, Kollet O The important roles of your chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m mice. Leukemia 16: 19922003. 23. Pituch-Noworolska A, Majka M, Janowska-Wieczorek A, Baj-Krzyworzeka M, Urbanowicz B, et al. Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an alternative hypothesis to stem cell plasticity. Folia Histochem Cytobiol 41: 1321. 24. Hattori K, Heissig B, Tashiro K, Honjo T, Tateno M, et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 97: 33543360. 25. Nagasawa T, Kikutani H, Kishimoto T Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc Natl Acad Sci U S A 91: 2305 2309. 26. Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T, et al. Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins. Science 261: 600603. 27. De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, et al. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 104: 34723482. 28. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635638. 29. Tang YL, Qian K, Zhang YC, Shen L, Phillips MI Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha remedy. Regul Pept 125: 18. 30. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC The chemokine SDF-1 is often a chemoattractant for human CD34+ hematopoietic progenitor cells and delivers a new mechanism to clarify the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185: 111120. 31. Lia.O K, Tada H, et al. Structure and chromosomal localization of your human stromal cell-derived factor 1 gene. Genomics 28: 495500. De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, et al. Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood 103: 24522459. 10. 11. 12. 13. 14. 15. six Mobilization of Stem Cells after Stroke 16. Vila-Coro AJ, Rodriguez-Frade JM, Martin De Ana A, Moreno-Ortiz MC, Martinez AC, et al. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J 13: 16991710. 17. Reddy K, Zhou Z, Jia SF, Lee TH, Morales-Arias J, et al. Stromal cellderived factor-1 stimulates vasculogenesis and enhances Ewing’s sarcoma tumor development within the absence of vascular endothelial growth element. Int J Cancer 123: 831837. 18. Juarez J, Bendall L SDF-1 and CXCR4 in typical and malignant hematopoiesis. Histol Histopathol 19: 299309. 19. Kucia M, Jankowski K, Reca R, Wysoczynski M, Bandura L, et al. CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion. J Mol Histol 35: 233245. 20. Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med 203: 22012213. 21. Ma Q, Jones D, Borghesani PR, Segal RA, Nagasawa T, et al. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A 95: 94489453. 22. Lapidot T, Kollet O The necessary roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m mice. Leukemia 16: 19922003. 23. Pituch-Noworolska A, Majka M, Janowska-Wieczorek A, Baj-Krzyworzeka M, Urbanowicz B, et al. Circulating CXCR4-positive stem/progenitor cells compete for SDF-1-positive niches in bone marrow, muscle and neural tissues: an option hypothesis to stem cell plasticity. Folia Histochem Cytobiol 41: 1321. 24. Hattori K, Heissig B, Tashiro K, Honjo T, Tateno M, et al. Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells. Blood 97: 33543360. 25. Nagasawa T, Kikutani H, Kishimoto T Molecular cloning and structure of a pre-B-cell growth-stimulating issue. Proc Natl Acad Sci U S A 91: 2305 2309. 26. Tashiro K, Tada H, Heilker R, Shirozu M, Nakano T, et al. Signal sequence trap: a cloning technique for secreted proteins and form I membrane proteins. Science 261: 600603. 27. De Falco E, Porcelli D, Torella AR, Straino S, Iachininoto MG, et al. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 104: 34723482. 28. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382: 635638. 29. Tang YL, Qian K, Zhang YC, Shen L, Phillips MI Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha treatment. Regul Pept 125: 18. 30. Aiuti A, Webb IJ, Bleul C, Springer T, Gutierrez-Ramos JC The chemokine SDF-1 is usually a chemoattractant for human CD34+ hematopoietic progenitor cells and offers a new mechanism to clarify the mobilization of CD34+ progenitors to peripheral blood. J Exp Med 185: 111120. 31. Lia.