Alogliptin 6-chloro-d3

Product Name :
Alogliptin 6-chloro-d3

Description:
Product information

CAS:
1794937-18-0

Molecular Weight:
278.71

Formula:
C13H10ClN3O2

Chemical Name:
2-{[6-chloro-3-(²H₃)methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]methyl}benzonitrile

Smiles :
[2H]C([2H])([2H])N1C(=O)N(CC2=CC=CC=C2C#N)C(Cl)=CC1=O

InChiKey:
BVUJISIVAHYNLI-FIBGUPNXSA-N

InChi :
InChI=1S/C13H10ClN3O2/c1-16-12(18)6-11(14)17(13(16)19)8-10-5-3-2-4-9(10)7-15/h2-6H,8H2,1H3/i1D3

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Belatacept} site|{Belatacept} Protocol|{Belatacept} Purity|{Belatacept} custom synthesis|{Belatacept} Autophagy}

Shelf Life:
≥12 months if stored properly.{{Corn oil} MedChemExpress|{Corn oil} {Biochemical Assay Reagents}|{Corn oil} Purity & Documentation|{Corn oil} Formula|{Corn oil} custom synthesis|{Corn oil} Epigenetic Reader Domain}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32491691

Additional information:
Product information|CAS Number: 1794937-18-0|Molecular Weight: 278.71|Formula: C13H10ClN3O2|Chemical Name: 2-{[6-chloro-3-(²H₃)methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]methyl}benzonitrile|Smiles: [2H]C([2H])([2H])N1C(=O)N(CC2=CC=CC=C2C#N)C(Cl)=CC1=O|InChiKey: BVUJISIVAHYNLI-FIBGUPNXSA-N|InChi: InChI=1S/C13H10ClN3O2/c1-16-12(18)6-11(14)17(13(16)19)8-10-5-3-2-4-9(10)7-15/h2-6H,8H2,1H3/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Methotrexate

Product Name :
Methotrexate

Sequence:

Purity:
≥98% (HPLC)

Molecular Weight:
454.5

Solubility :
Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.

Appearance:
Yellow powder.

Use/Stability :
As indicated on product label or CoA when stored as recommended.

Description:
Dihydrofolate reductase inhibitor Folic acid antagonist. Potent inhibitor of dihydrofolate reductase.{{1393477-72-9} site|{1393477-72-9} Protocol|{1393477-72-9} References|{1393477-72-9} supplier} Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

CAS :
133073-73-1

Solubility:
Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.{{2230836-55-0} web|{2230836-55-0} Protocol|{2230836-55-0} Data Sheet|{2230836-55-0} custom synthesis}

Formula:
C20H22N8O5 .PMID:25905184 H2O

Additional Information :
| Alternative Name (+)-Amethopterin, 4-Amino-10-methylfolic acid, Methylaminopterin, MTX | Appearance Yellow powder. | CAS 133073-73-1 | Couple Target Dihydrofolate reductase | Couple Type Inhibitor | Formula C20H22N8O5 . H2O | MI 14: 5985 | MW 454.5 | Purity ≥98% (HPLC) | Solubility Soluble in alkaline solution; insoluble in water, 100% ethanol or ether. | Unit of Measure (UM) g, mg

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Matrix Metalloproteinase-13 (MMP-13) colorimetric drug discovery kit

Product Name :
Matrix Metalloproteinase-13 (MMP-13) colorimetric drug discovery kit

Sequence:

Purity:

Molecular Weight:

Solubility :

Appearance:

Use/Stability :

Description:
A QUANTIZYME® Assay System. The MMP-13 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-13 (MMP-13, collagenase-3) using a thiopeptide as a chromogenic substrate. The assays are performed in a convenient 96-well microplate format. Included are active enzyme, assay buffer, a prototypic control inhibitor (NNGH), and a detailed instruction booklet.

CAS :

Solubility:

Formula:

Additional Information :
| Alternative Name Collagenase-3 | Application Colorimetric detection, HTS | Contents MMP-13 enzyme (human) (recombinant), substrate, inhibitor, assay buffer, 96-well microplate.{{259793-96-9} site|{259793-96-9} Purity & Documentation|{259793-96-9} Data Sheet|{259793-96-9} custom synthesis} | UniProt ID P45452

{{26993-30-6} web|{26993-30-6} Technical Information|{26993-30-6} In Vitro|{26993-30-6} custom synthesis} PMID:30725832 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

1-Acetyl-3-o-toluyl-5-fluorouracil

Product Name :
1-Acetyl-3-o-toluyl-5-fluorouracil

Description:
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.

CAS:
71861-76-2

Molecular Weight:
290.25

Formula:
C14H11FN2O4

Chemical Name:
1-acetyl-5-fluoro-3-(2-methylbenzoyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Smiles :
CC(=O)N1C=C(F)C(=O)N(C(=O)C2=CC=CC=C2C)C1=O

InChiKey:
DRXHAKVGNKHFMB-UHFFFAOYSA-N

InChi :
InChI=1S/C14H11FN2O4/c1-8-5-3-4-6-10(8)12(19)17-13(20)11(15)7-16(9(2)18)14(17)21/h3-7H,1-2H3

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.|Product information|CAS Number: 71861-76-2|Molecular Weight: 290.25|Formula: C14H11FN2O4|Chemical Name: 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione|Smiles: CC(=O)N1C=C(F)C(=O)N(C(=O)C2=CC=CC=C2C)C1=O|InChiKey: DRXHAKVGNKHFMB-UHFFFAOYSA-N|InChi: InChI=1S/C14H11FN2O4/c1-8-5-3-4-6-10(8)12(19)17-13(20)11(15)7-16(9(2)18)14(17)21/h3-7H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{D-Cycloserine} site|{D-Cycloserine} Anti-infection|{D-Cycloserine} Protocol|{D-Cycloserine} In stock|{D-Cycloserine} manufacturer|{D-Cycloserine} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Mirin} MedChemExpress|{Mirin} PI3K/Akt/mTOR|{Mirin} Purity & Documentation|{Mirin} In Vitro|{Mirin} supplier|{Mirin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31985186 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

LAG-3 (human) recombinant monoclonal antibody (L4-PL33) (PBS only)

Product Name :
LAG-3 (human) recombinant monoclonal antibody (L4-PL33) (PBS only)

Sequence:

Purity:

Molecular Weight:

Solubility :

Appearance:

Use/Stability :
Stable for at least 6 months after receipt when stored as recommended.

Description:
The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4.{{1774353-12-6} MedChemExpress|{1774353-12-6} Technical Information|{1774353-12-6} Description|{1774353-12-6} manufacturer} Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.{{945604-76-2} site|{945604-76-2} Purity & Documentation|{945604-76-2} Formula|{945604-76-2} supplier} e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa). The longer form was detected by ELISA in the serum of healthy individuals as well as of tuberculosis patients with a favorable outcome. LAG-3 expression by T cell clones correlated with IFN-γ production, and hence soluble LAG-3 has been suggested as a serological marker of Th1 responses. Western blot analysis of LAG-3 mAb (L4-PL33) : Lane 1: MW marker, Lane 2: LAG-3 (human):Fc (human), (recombinant) . Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human tonsil tissue stained with LAG-3 (human) recombinant mAb (L4-PL33) at 6μg/ml. Flow cytometry analysis of 0.5×10^6 THP-1 cells stained using LAG-3 mAb (L4-PL33) at a concentration of 5μg/ml, followed by Alexa Fluor® 488 conjugated anti-mouse secondary antibody. Western blot analysis of LAG-3 mAb (L4-PL33) : Lane 1: MW marker, Lane 2: LAG-3 (human):Fc (human), (recombinant) . Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human tonsil tissue stained with LAG-3 (human) recombinant mAb (L4-PL33) at 6μg/ml. Flow cytometry analysis of 0.5×10^6 THP-1 cells stained using LAG-3 mAb (L4-PL33) at a concentration of 5μg/ml, followed by Alexa Fluor® 488 conjugated anti-mouse secondary antibody.

CAS :

Solubility:

Formula:

Additional Information :
| Alternative Name Lymphocyte activation gene-3, FDC protein, CD223 | Application ELISA, Flow Cytometry, ICC, IHC, IP, WB | Clone L4-PL33 | Formulation Liquid.PMID:20301692 In PBS-only. Preservative and stabilizer free. | GenBank ID NM_002286 | Host Mouse | Immunogen Synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3). | Isotype IgG1κ | Recommendation Dilutions/Conditions Flow Cytometry (1:100)Immunohistochemistry (frozen sections, 1:150; FFPE sections, 1:150)Western Blot (1-5 µg/ml)Immunoprecipitation (10 µg/ml)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from tissue culture supernatant. | Species Reactivity Human | Specificity Recognizes the 30 aa extra-loop of the first N-terminal D1 domain of LAG-3. | UniProt ID P18627 | Unit of Measure (UM) µg

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HSP90β monoclonal antibody (K3705)

Product Name :
HSP90β monoclonal antibody (K3705)

Sequence:

Purity:

Molecular Weight:

Solubility :

Appearance:

Use/Stability :

Description:
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents. Immunohistochemistry analysis of human breast cancer tissue using Hsp90β mAb (K3705). Western blot analysis of HSP90β: Lane 1: MW marker, Lane 2: HSP90 Native Human Protein, Lane 3: HSP90α Recombinant Human Protein, Lane 4: HSP90β Recombinant Human Protein, Lane 5: HeLa, Lane 6: PC-12, Lane 7: CHO-K1, Lane 8: 3T3.{{2173054-79-8} site|{2173054-79-8} Purity & Documentation|{2173054-79-8} In Vitro|{2173054-79-8} manufacturer} Immunohistochemistry analysis of human breast cancer tissue using Hsp90β mAb (K3705). Western blot analysis of HSP90β: Lane 1: MW marker, Lane 2: HSP90 Native Human Protein, Lane 3: HSP90α Recombinant Human Protein, Lane 4: HSP90β Recombinant Human Protein, Lane 5: HeLa, Lane 6: PC-12, Lane 7: CHO-K1, Lane 8: 3T3.{{1900754-56-4} medchemexpress|{1900754-56-4} Technical Information|{1900754-56-4} Formula|{1900754-56-4} custom synthesis}

CAS :

Solubility:

Formula:

Additional Information :
| Alternative Name HSP86, Heat shock protein 90β | Application IHC, WB | Application Notes Detects a band of ~90kDa by Western blot.PMID:30358967 | Clone K3705 | Formulation Liquid. In saline, pH 6.9, containing 0.1% sodium azide. | Host Mouse | Immunogen Recombinant human HSP90β. | Isotype IgM | Recommendation Dilutions/Conditions Immunohistochemistry (1:50)Western Blot (1:1,000, colorimetric)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from hybridoma tissue culture supernatant. | Species Reactivity Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Mouse, Porcine, Rat, Sheep | UniProt ID P08238 | Unit of Measure (UM) µg

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Viquidil hydrochloride

Product Name :
Viquidil hydrochloride

Description:
Viquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity.

CAS:
52211-63-9

Molecular Weight:
360.88

Formula:
C20H25ClN2O2

Chemical Name:
3-[(3R,4R)-3-ethenylpiperidin-4-yl]-1-(6-methoxyquinolin-4-yl)propan-1-one hydrochloride

Smiles :
Cl.COC1=CC2=C(C=CN=C2C=C1)C(=O)CC[C@@H]1CCNC[C@@H]1C=C

InChiKey:
YUBRJAHSRSIPKX-LDXVYITESA-N

InChi :
InChI=1S/C20H24N2O2.ClH/c1-3-14-13-21-10-8-15(14)4-7-20(23)17-9-11-22-19-6-5-16(24-2)12-18(17)19;/h3,5-6,9,11-12,14-15,21H,1,4,7-8,10,13H2,2H3;1H/t14-,15+;/m0./s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Viquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity.|Product information|CAS Number: 52211-63-9|Molecular Weight: 360.88|Formula: C20H25ClN2O2|Chemical Name: 3-[(3R,4R)-3-ethenylpiperidin-4-yl]-1-(6-methoxyquinolin-4-yl)propan-1-one hydrochloride|Smiles: Cl.{{Fmoc-L-Trp(Boc)-OH} site|{Fmoc-L-Trp(Boc)-OH} {Amino Acid Derivatives}|{Fmoc-L-Trp(Boc)-OH} Technical Information|{Fmoc-L-Trp(Boc)-OH} Description|{Fmoc-L-Trp(Boc)-OH} supplier|{Fmoc-L-Trp(Boc)-OH} Autophagy} COC1=CC2=C(C=CN=C2C=C1)C(=O)CC[C@@H]1CCNC[C@@H]1C=C|InChiKey: YUBRJAHSRSIPKX-LDXVYITESA-N|InChi: InChI=1S/C20H24N2O2.{{Ferritin heavy chain/FTH1 Protein, Human} web|{Ferritin heavy chain/FTH1 Protein, Human} Biological Activity|{Ferritin heavy chain/FTH1 Protein, Human} References|{Ferritin heavy chain/FTH1 Protein, Human} custom synthesis|{Ferritin heavy chain/FTH1 Protein, Human} Epigenetics} ClH/c1-3-14-13-21-10-8-15(14)4-7-20(23)17-9-11-22-19-6-5-16(24-2)12-18(17)19;/h3,5-6,9,11-12,14-15,21H,1,4,7-8,10,13H2,2H3;1H/t14-,15+;/m0.PMID:32529926 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 15 mg/mL (41.57 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Viquidil hydrochloride (Quinotoxine hydrochloride) increases the cerebral blood flow in the rabbit considerably.|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Nordihydrocapsaicin

Product Name :
Nordihydrocapsaicin

Description:
Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers.

CAS:
28789-35-7

Molecular Weight:
293.40

Formula:
C17H27NO3

Chemical Name:
N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyloctanamide

Smiles :
COC1=CC(CNC(=O)CCCCCC(C)C)=CC=C1O

InChiKey:
VQEONGKQWIFHMN-UHFFFAOYSA-N

InChi :
InChI=1S/C17H27NO3/c1-13(2)7-5-4-6-8-17(20)18-12-14-9-10-15(19)16(11-14)21-3/h9-11,13,19H,4-8,12H2,1-3H3,(H,18,20)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers.{{Isradipine} MedChemExpress|{Isradipine} Calcium Channel|{Isradipine} Biological Activity|{Isradipine} In Vivo|{Isradipine} supplier|{Isradipine} Autophagy} |Product information|CAS Number: 28789-35-7|Molecular Weight: 293.40|Formula: C17H27NO3|Chemical Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyloctanamide|Smiles: COC1=CC(CNC(=O)CCCCCC(C)C)=CC=C1O|InChiKey: VQEONGKQWIFHMN-UHFFFAOYSA-N|InChi: InChI=1S/C17H27NO3/c1-13(2)7-5-4-6-8-17(20)18-12-14-9-10-15(19)16(11-14)21-3/h9-11,13,19H,4-8,12H2,1-3H3,(H,18,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Salinomycin} MedChemExpress|{Salinomycin} Wnt|{Salinomycin} NF-κB|{Salinomycin} Technical Information|{Salinomycin} Formula|{Salinomycin} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:31985940 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

[Gln8]-C517 (LH-RH), chicken

Product Name :
[Gln8]-C517 (LH-RH), chicken

Description:
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.

CAS:
47922-48-5

Molecular Weight:
1154.23

Formula:
C54H71N15O14

Chemical Name:
(4S)-5-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-4-[(2S)-2-{2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamido]-5-oxopentanamide

Smiles :
CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O

InChiKey:
WPKQYFUSPONRAT-BXXNOCLASA-N

InChi :
InChI=1S/C54H71N15O14/c1-28(2)18-37(49(78)64-36(13-15-43(55)72)54(83)69-17-5-8-42(69)53(82)59-24-44(56)73)63-46(75)25-60-47(76)38(19-29-9-11-32(71)12-10-29)65-52(81)41(26-70)68-50(79)39(20-30-22-58-34-7-4-3-6-33(30)34)66-51(80)40(21-31-23-57-27-61-31)67-48(77)35-14-16-45(74)62-35/h3-4,6-7,9-12,22-23,27-28,35-42,58,70-71H,5,8,13-21,24-26H2,1-2H3,(H2,55,72)(H2,56,73)(H,57,61)(H,59,82)(H,60,76)(H,62,74)(H,63,75)(H,64,78)(H,65,81)(H,66,80)(H,67,77)(H,68,79)/t35-,36-,37-,38-,39-,40-,41-,42-/m0/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ixekizumab} MedChemExpress|{Ixekizumab} Immunology/Inflammation|{Ixekizumab} Purity & Documentation|{Ixekizumab} Description|{Ixekizumab} manufacturer|{Ixekizumab} Epigenetics}

Shelf Life:
≥12 months if stored properly.{{TLQP-21} web|{TLQP-21} Agonist|{TLQP-21} Epigenetics|{TLQP-21} Purity & Documentation|{TLQP-21} In Vitro|{TLQP-21} supplier}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32750860

Additional information:
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.|Product information|CAS Number: 47922-48-5|Molecular Weight: 1154.23|Formula: C54H71N15O14|Chemical Name: (4S)-5-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-4-[(2S)-2-{2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamido]-5-oxopentanamide|Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O|InChiKey: WPKQYFUSPONRAT-BXXNOCLASA-N|InChi: InChI=1S/C54H71N15O14/c1-28(2)18-37(49(78)64-36(13-15-43(55)72)54(83)69-17-5-8-42(69)53(82)59-24-44(56)73)63-46(75)25-60-47(76)38(19-29-9-11-32(71)12-10-29)65-52(81)41(26-70)68-50(79)39(20-30-22-58-34-7-4-3-6-33(30)34)66-51(80)40(21-31-23-57-27-61-31)67-48(77)35-14-16-45(74)62-35/h3-4,6-7,9-12,22-23,27-28,35-42,58,70-71H,5,8,13-21,24-26H2,1-2H3,(H2,55,72)(H2,56,73)(H,57,61)(H,59,82)(H,60,76)(H,62,74)(H,63,75)(H,64,78)(H,65,81)(H,66,80)(H,67,77)(H,68,79)/t35-,36-,37-,38-,39-,40-,41-,42-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com

Sandramycin

Product Name :
Sandramycin

Description:
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.

CAS:
100940-65-6

Molecular Weight:
1221.32

Formula:
C60H76N12O16

Chemical Name:
3-hydroxy-N-[(3R, 7S, 16S, 23R, 27S, 36S)-23-(3-hydroxyquinoline-2-amido)-8, 11, 28, 31-tetramethyl-2, 6, 9, 12, 15, 22, 26, 29, 32, 35-decaoxo-7, 27-bis(propan-2-yl)-5, 25-dioxa-1, 8, 11, 14, 21, 28, 31, 34-octaazatricyclo[34.4.0.0, ]tetracontan-3-yl]quinoline-2-carboxamide

Smiles :
CN1CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC1=O

InChiKey:
WXIVYIYCEBUEHL-RTQGILJWSA-N

InChi :
InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)/t39-,40-,41+,42+,51+,52+/m1/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥360 days if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.|Product information|CAS Number: 100940-65-6|Molecular Weight: 1221.{{SMARCA2/4-IN-2} MedChemExpress|{SMARCA2/4-IN-2} PROTAC|{SMARCA2/4-IN-2} Activator|{SMARCA2/4-IN-2} Protocol|{SMARCA2/4-IN-2} Formula|{SMARCA2/4-IN-2} supplier} 32|Formula: C60H76N12O16|Chemical Name: 3-hydroxy-N-[(3R, 7S, 16S, 23R, 27S, 36S)-23-(3-hydroxyquinoline-2-amido)-8, 11, 28, 31-tetramethyl-2, 6, 9, 12, 15, 22, 26, 29, 32, 35-decaoxo-7, 27-bis(propan-2-yl)-5, 25-dioxa-1, 8, 11, 14, 21, 28, 31, 34-octaazatricyclo[34.4.0.0, ]tetracontan-3-yl]quinoline-2-carboxamide|Smiles: CN1CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC1=O|InChiKey: WXIVYIYCEBUEHL-RTQGILJWSA-N|InChi: InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)/t39-,40-,41+,42+,51+,52+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Opipramol} MedChemExpress|{Opipramol} Sigma Receptor|{Opipramol} Biological Activity|{Opipramol} In Vivo|{Opipramol} supplier|{Opipramol} Epigenetics} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sandramycin has antimicrobial activity wtih MIC values of 0.PMID:32329329 024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively. Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.|In Vivo:|Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice.|References:|J A Matson, et al. Sandramycin, a Novel Antitumor Antibiotic Produced by a Nocardioides Sp. Production, Isolation, Characterization and Biological Properties. J Antibiot (Tokyo). 1989 Dec;42(12):1763-7.Katsushi Katayama, et al. Total Synthesis of Sandramycin and Its Analogues via a Multicomponent Assemblage. Org Lett. 2014 Jan 17;16(2):428-31.Products are for research use only. Not for human use.|

MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com