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Sodium Houttuyfonate is a natural compound extracted from Houttuynia cordata, with anti-inflammatory and anti-fibrotic effects. Sodium Houttuyfonate ameliorates LPS induced mastitis by inhibiting the NF κB pathway.|Product information|CAS Number: 83766-73-8|Molecular Weight: 302.36|Formula: C12H23NaO5S|Chemical Name: sodium 1-hydroxy-3-oxododecane-1-sulfonate|Smiles: [Na+].CCCCCCCCCC(=O)CC(O)S([O-])(=O)=O|InChiKey: HPPWMWCITPGPKK-UHFFFAOYSA-M|InChi: InChI=1S/C12H24O5S.Na/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)18(15,16)17;/h12,14H,2-10H2,1H3,(H,15,16,17);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sodium houttuyfonate (25-100 mM) decreases apoptosis of MLE-15 cells induced by CS experiment and inhibits JNK pathway.Toripalimab custom synthesis |In Vivo:|Sodium Houttuyfonate (10-40 mg/kg; p.PMID:33337694 o. for 28 d) reduces lung injury, apoptosis in lung tissues, and the wet/dry (W/D) ratio in ventilator-induced lung injury (VILI) mice. Sodium Houttuyfonate (40 mg/kg; p.o. for 28 d) reduces ROS level and inhibits JNK pathway in VILI mice. Sodium Houttuyfonate (25-100 mg/kg; p.o. once daily for 28 d) ameliorates spatial learning and memory deficiency in Aβ1-42-induced Alzheimer’s disease mice.|References:|Liu Y, et, al. Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation. Yonsei Med J. 2021 Jun;62(6):545-554.Liu X, et, al. Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects. Eur J Pharmacol. 2021 Jul 5;902:174110.Zhao Y, et, al. Sodium Houttuyfonate Ameliorates β-amyloid 1-42-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer’s Disease. Mediators Inflamm. 2021 May 31;2021:8817698.Ma K, et, al. Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β-glucan exposure. J Leukoc Biol. 2021 Mar 8.Products are for research use only. Not for human use.|

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Ibrutinib, also known as PCI-32765, is a potent and orally active BTK inhibitor. Ibrutinib binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK. Ibrutinib was approved by the US FDA on November 13, 2013 for the treatment of mantle cell lymphoma.|Product information|CAS Number: 936563-87-0|Molecular Weight: 440.50|Formula: C25H24N6O2|Synonym:|Ibrutinib Racemate|PCI32765 Racemate|PCI 32765 Racemate|Chemical Name: 1-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-ylprop-2-en-1-one|Smiles: C=CC(=O)N1CC(CCC1)N1N=C(C2=C(N)N=CN=C12)C1C=CC(=CC=1)OC1C=CC=CC=1|InChiKey: XYFPWWZEPKGCCK-UHFFFAOYSA-N|InChi: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Rotenone site |Shelf Life: ≥12 months if stored properly.Apolipoprotein A-I Protein, Human custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32310458 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|PCI-32765 Racemate is oral effective in vivo. It induces lymphocytosis during the first weeks of therapy in patients with CLL. It is also efficacious in autoimmune disease. In the MRL-Fas lupus model, PCI-32765 inhibits collagen-induced arthritis as well as autoantibody production and development of kidney disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines.|References:|Burger JA, Buggy JJ. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma. 2013 Nov;54(11):2385-91.Products are for research use only. Not for human use.|

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Tobramycin is a broad-spectrum antibiotic.|Product information|CAS Number: 32986-56-4|Molecular Weight: 467.51|Formula: C18H37N5O9|Synonym:|Nebramycin Factor 6|Deoxykanamycin B|Chemical Name: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol|Smiles: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O|InChiKey: NLVFBUXFDBBNBW-PBSUHMDJSA-N|InChi: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Calcein Technical Information |Shelf Life: ≥12 months if stored properly.PMID:32567410 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.|Product information|CAS Number: 76060-35-0|Molecular Weight: 290.35|Formula: C17H22O4|Chemical Name: (1E)-1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3, 5-dione|Smiles: CCCCCC(=O)CC(=O)/C=C/C1=CC(OC)=C(O)C=C1|InChiKey: JUKHKHMSQCQHEN-VQHVLOKHSA-N|InChi: InChI=1S/C17H22O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h7-11,20H,3-6,12H2,1-2H3/b9-7+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pindolol Purity & Documentation |Shelf Life: ≥12 months if stored properly.PMID:33211278 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways. 6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation. 6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway.|References:|Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.Products are for research use only. Not for human use.|

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Abexinostat, also known as PCI-24781 or CRA-024781, is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.Flunarizine custom synthesis |Product information|CAS Number: 58-33-3|Molecular Weight: 320.PMID:31994151 88|Formula: C17H21ClN2S|Synonym:|Diprazin|Romergan|Lergigan|Phenergan|Fellozine|NSC-231688|Chemical Name: dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine hydrochloride|Smiles: Cl.CN(C)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12|InChiKey: XXPDBLUZJRXNNZ-UHFFFAOYSA-N|InChi: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Pyridoclax, also known as MR29072, is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells.Nelfinavir supplier Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy.Isocarboxazid medchemexpress Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic.|Product information|CAS Number: 1651890-44-6|Molecular Weight: 426.51|Formula: C29H22N4|Synonym:|MR-29072|Chemical Name: 3-methyl-5-5-[(E)-2-phenylethenyl]-[3,3′-bipyridin]-6-yl-2,3′-bipyridine|Smiles: CC1=CC(=CN=C1C1=CN=CC=C1)C1=NC=C(C=C1/C=C/C1C=CC=CC=1)C1=CN=CC=C1|InChiKey: WGGSYXQFYRWBEC-VAWYXSNFSA-N|InChi: InChI=1S/C29H22N4/c1-21-15-27(20-32-28(21)25-10-6-14-31-18-25)29-23(12-11-22-7-3-2-4-8-22)16-26(19-33-29)24-9-5-13-30-17-24/h2-20H,1H3/b12-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32272822 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Gloaguen C, Voisin-Chiret AS, Sopkova-de Oliveira Santos J, Fogha J, Gautier F, De Giorgi M, Burzicki G, Perato S, Pétigny-Lechartier C, Simonin-Le Jeune K, Brotin E, Goux D, N’Diaye M, Lambert B, Louis MH, Ligat L, Lopez F, Juin P, Bureau R, Rault S, Poulain L. First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies. J Med Chem. 2015 Feb 26;58(4):1644-68.Products are for research use only. Not for human use.|