Additional information:
Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.|Product information|CAS Number: 30034-03-8|Molecular Weight: 484.{{Ketoconazole} site|{Ketoconazole} Anti-infection|{Ketoconazole} Protocol|{Ketoconazole} References|{Ketoconazole} manufacturer|{Ketoconazole} Autophagy} 48|Formula: C18H17N6NaO5S2|Chemical Name: sodium (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.{{Tirofiban} MedChemExpress|{Tirofiban} Integrin|{Tirofiban} Technical Information|{Tirofiban} References|{Tirofiban} manufacturer|{Tirofiban} Cancer} 2.PMID:23865629 0]oct-2-ene-2-carboxylate|Smiles: [Na+].CN1N=NN=C1SCC1CS[C@@H]2[C@H](NC(=O)[C@H](O)C3=CC=CC=C3)C(=O)N2C=1C([O-])=O|InChiKey: OJMNTWPPFNMOCJ-CFOLLTDRSA-M|InChi: InChI=1S/C18H18N6O5S2.Na/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9;/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29);/q;+1/p-1/t11-,13-,16-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (103.20 mM; Need ultrasonic). H2O : 33.33 mg/mL (68.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Arctiin is a lignan found in many plants of the Asteraceae family, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla.{{Trastuzumab (anti-HER2)} medchemexpress|{Trastuzumab (anti-HER2)} JAK/STAT Signaling|{Trastuzumab (anti-HER2)} NF-κB|{Trastuzumab (anti-HER2)} Biological Activity|{Trastuzumab (anti-HER2)} Formula|{Trastuzumab (anti-HER2)} supplier} , and Forsythia viridissima. It is the glucoside of arctigenin. Arctiin and arctigenin have shown anticancer effects.|Product information|CAS Number: 20362-31-6|Molecular Weight: 534.55|Formula: C27H34O11|Chemical Name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]oxolan-2-one|Smiles: COC1=CC=C(C[C@H]2COC(=O)[C@@H]2CC2=CC(OC)=C(C=C2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1OC|InChiKey: XOJVHLIYNSOZOO-SWOBOCGESA-N|InChi: InChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24487575 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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TIC10 isomer is an isomer and the “inactive version” of TIC10. TIC-10 isomer was introduced to the research community since it was structurally wrong-assigned as the bioactive TIC-10 during early stage development of TIC-10 (now called ONC-201).{{Atropine} medchemexpress|{Atropine} Metabolic Enzyme/Protease|{Atropine} Technical Information|{Atropine} Description|{Atropine} supplier|{Atropine} Epigenetic Reader Domain} TIC-10 isomer was found to be inactive, which did not reduce the viability of cancer cells.PMID:23291014 TIC-10 isomer may be used as a reference compound to compare with ONC-201.|Product information|CAS Number: 41276-02-2|Molecular Weight: 386.49|Formula: C24H26N4O|Chemical Name: 11-benzyl-2-[(2-methylphenyl)methyl]-2,4,7,11-tetraazatricyclo[7.4.0.0³,⁷]trideca-1(9),3-dien-8-one|Smiles: CC1=CC=CC=C1CN1C2=NCCN2C(=O)C2CN(CC3C=CC=CC=3)CCC1=2|InChiKey: RSAQARAFWMUYLL-UHFFFAOYSA-N|InChi: InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-22-11-13-26(15-19-8-3-2-4-9-19)17-21(22)23(29)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. IC50 value:Target: c-MetMore details please refer to Patent WO 2012015677 A1.|Product information|CAS Number: 1357072-61-7|Molecular Weight: 362.41|Formula: C17H14N8S|Chemical Name: 2-methyl-5-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-2H-indazole|Smiles: CN1C=C2C=C(C=CC2=N1)SC1=NN=C2C=CC(=NN21)C1C=NN(C)C=1|InChiKey: JYXHZDNTBJUJNH-UHFFFAOYSA-N|InChi: InChI=1S/C17H14N8S/c1-23-10-12(8-18-23)15-5-6-16-19-20-17(25(16)22-15)26-13-3-4-14-11(7-13)9-24(2)21-14/h3-10H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Xevinapant} MedChemExpress|{Xevinapant} IAP|{Xevinapant} Purity & Documentation|{Xevinapant} Formula|{Xevinapant} custom synthesis|{Xevinapant} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.PMID:35850484 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Dasabuvir, also known as ABT-333, is a non-nucleoside polymerase inhibitor currently under clinical trials for the treatment of Hepatitis C. In the United States, it is approved by the Food and Drug Administration for use in combination with ombitasvir, paritaprevir, and ritonavir in the product Viekira Pak. Dasabuvir acts as a NS5B (an RNA-directed RNA polymerase) inhibitor.|Product information|CAS Number: 1132935-63-7|Molecular Weight: 493.57|Formula: C26H27N3O5S|Synonym:|Dasabuvir|ABT333|ABT 333|Chemical Name: N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide|Smiles: COC1C(=CC(=CC=1C(C)(C)C)N1C=CC(=O)NC1=O)C1=CC2=CC=C(C=C2C=C1)NS(C)(=O)=O|InChiKey: NBRBXGKOEOGLOI-UHFFFAOYSA-N|InChi: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ABT-333 (Dasabuvir) is at least 7, 000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. ABT-333 (Dasabuvir) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM. ABT-333 inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.{{OPC 4392} site|{OPC 4392} Dopamine Receptor|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} In Vivo|{OPC 4392} supplier} 7 and 1.{{Mecillinam} medchemexpress|{Mecillinam} Antibiotic|{Mecillinam} Epigenetics|{Mecillinam} Protocol|{Mecillinam} References|{Mecillinam} supplier} 8 nM against genotype 1a (H77) and 1b (Con1), respectively.PMID:23756629 In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.|In Vivo:|The recombinant HCV polymerases used in this study contain the first 570 amino acids of the 591-amino acid native protein sequence, with a six-histidine tag at the N terminus to facilitate purification by affinity chromatography. Briefly, ABT-333 (Dasabuvir) is incubated with 5 to 50 nM polymerase for 15 min at room temperature, follow by the addition of nucleoside triphosphates (NTPs) and [3H]UTP for 3 h at 30°C. After termination of the reaction, the precipitated RNA is captured by filtration through a GF/B filter. The amount of incorporated [3H]UTP is measured by scintillation counting with a Wallac 1450 MicroBeta counter. The percent inhibition is calculated from the initial rates of inhibited reactions relative to that of the uninhibited control reaction. The mean 50% inhibitory concentration (IC50) and the standard error of the mean (SEM) are calculated via nonlinear regression.|References:|Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.Products are for research use only. Not for human use.|

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Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Enoxacin is a broad-spectrum antibacterial agent that is structurally related to nalidixic acid. It acts on DNA gyrase.{{Baclofen} medchemexpress|{Baclofen} Membrane Transporter/Ion Channel|{Baclofen} Protocol|{Baclofen} In stock|{Baclofen} manufacturer|{Baclofen} Epigenetics} Insomnia is a common adverse effect. Recently, enoxacin has been shown recently that it may have cancer inhibiting effect.|Product information|CAS Number: 74011-58-8|Molecular Weight: 320.32|Formula: C15H17FN4O3|Synonym:|Penetrex|AT 2266|CI 919|Chemical Name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid|Smiles: CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N=C12)N1CCNCC1|InChiKey: IDYZIJYBMGIQMJ-UHFFFAOYSA-N|InChi: InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{OPC 4392} site|{OPC 4392} GPCR/G Protein|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} Purity|{OPC 4392} supplier} |Shelf Life: ≥12 months if stored properly.PMID:23291014 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.|Product information|CAS Number: 2222768-84-3|Molecular Weight: 431.50|Formula: C22H23F2N3O2S|Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate|Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC|InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker.{{Sulfapyridine} MedChemExpress|{Sulfapyridine} Antibiotic|{Sulfapyridine} Biological Activity|{Sulfapyridine} Data Sheet|{Sulfapyridine} supplier|{Sulfapyridine} Epigenetics} SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of Product information|CAS Number: 2241690-03-7|Molecular Weight: 1122.PMID:23892746 39|Formula: C66H83N5O11|Chemical Name: (2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide|Smiles: CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1|InChiKey: DXLPZZKVYXMXOP-UXACQRMVSA-N|InChi: InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Creatinine-D3 (NSC13123-D3) is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle.|Product information|CAS Number: 143827-20-7|Molecular Weight: 116.14|Formula: C4H7N3O|Chemical Name: 2-amino-1-(²H₃)methyl-4,5-dihydro-1H-imidazol-4-one|Smiles: [2H]C([2H])([2H])N1CC(=O)N=C1N|InChiKey: DDRJAANPRJIHGJ-FIBGUPNXSA-N|InChi: InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} MedChemExpress|{Rucaparib} Cell Cycle/DNA Damage|{Rucaparib} Protocol|{Rucaparib} Data Sheet|{Rucaparib} custom synthesis|{Rucaparib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23558135 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cd(II) protoporphyrin IX is a protoporphyrin IX. Protoporphyrin IX is a heterocyclic organic compound, which consists of four pyrrole rings, and is the final intermediate in the heme biosynthetic pathway.|Product information|CAS Number: 80216-25-7|Molecular Weight: 673.05|Formula: C34H32CdN4O4|Chemical Name: 10,14-bis(2-carboxyethyl)-4,19-diethenyl-5,9,15,20-tetramethyl-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),2,4,6,8,10,12,14,16,18-decaene-21,22,23,24-tetraide cadmium|Smiles: [Cd].CC1C(C=C)=C2C=C3[N-]C(=CC4[N-]C(C=C5[N-]C(=CC=1[N-]2)C(C=C)=C5C)=C(C)C=4CCC(O)=O)C(CCC(O)=O)=C3C |c:6,9,14,17||InChiKey: MPXUUHBENXDJJI-RGGAHWMASA-N|InChi: InChI=1S/C34H32N4O4.{{Purmorphamine} medchemexpress|{Purmorphamine} Smo|{Purmorphamine} Epigenetics|{Purmorphamine} Technical Information|{Purmorphamine} In Vitro|{Purmorphamine} supplier} Cd/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);/q-4;/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Afatinib dimaleate} site|{Afatinib dimaleate} Apoptosis|{Afatinib dimaleate} Immunology/Inflammation|{Afatinib dimaleate} Technical Information|{Afatinib dimaleate} Formula|{Afatinib dimaleate} custom synthesis} |Shelf Life: ≥12 months if stored properly.PMID:25046520 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|