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Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.|Product information|CAS Number: 68414-18-6|Molecular Weight: 581.30|Formula: C15H22N5NaO14P2|Chemical Name: sodium (2R,3R,4R)-5-[([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl phosphonato)oxy]-2,3,4-trihydroxypentanal|Smiles: [Na+].NC1N=CN=C2C=1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP([O-])(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)[C@@H](O)[C@H]1O|InChiKey: RJWGZGBNLLYUJC-KAXKLPFCSA-M|InChi: InChI=1S/C15H23N5O14P2.Na/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);/q;+1/p-1/t6-,7+,8+,10-,11+,12+,15+;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 125 mg/mL (215.04 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release.Obefazimod Formula This process eventually activates early or late autophagy in response to different degrees of oxidative stress.PAC web TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus.PMID:33370225 In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.|Products are for research use only. Not for human use.|

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DP-C-4 is a CRBN-based dual PROTAC for simultaneous degradation of EGFR and PARP.|Product information|Molecular Weight: 1450.93|Formula: C72H78ClF2N15O14|Chemical Name: 6-(4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yloxy)-N-2-[(1-2-[2-(2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]aminoethoxy)ethoxy]ethyl-1H-1,2,3-triazol-4-yl)methoxy]-1-[6-(4-2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoylpiperazin-1-yl)-6-oxohexyl]carbamoylethylhexanamide|Smiles: COC1C=C2N=CN=C(NC3C=C(Cl)C(F)=CC=3)C2=CC=1OCCCCCC(=O)NC(COCC1=CN(CCOCCOCCNC2=CC=CC3=C2C(=O)N(C2CCC(=O)NC2=O)C3=O)N=N1)C(=O)NCCCCCC(=O)N1CCN(CC1)C(=O)C1=CC(CC2=NNC(=O)C3C=CC=CC2=3)=CC=C1F|InChiKey: RXJUEWUXCCBXOG-UHFFFAOYSA-N|InChi: InChI=1S/C72H78ClF2N15O14/c1-100-60-39-56-51(66(79-43-78-56)80-45-18-20-54(75)52(73)37-45)38-61(60)104-30-9-3-4-15-62(91)81-58(42-103-41-46-40-89(86-83-46)29-32-102-34-33-101-31-24-76-55-14-10-13-49-65(55)72(99)90(71(49)98)59-21-22-63(92)82-69(59)96)68(95)77-23-8-2-5-16-64(93)87-25-27-88(28-26-87)70(97)50-35-44(17-19-53(50)74)36-57-47-11-6-7-12-48(47)67(94)85-84-57/h6-7,10-14,17-20,35,37-40,43,58-59,76H,2-5,8-9,15-16,21-34,36,41-42H2,1H3,(H,77,95)(H,81,91)(H,85,94)(H,78,79,80)(H,82,92,96)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DP-C-4 (1-50 μM; 24 hours) has degradation effects on EGFR and PARP simultaneously in a dose-dependent manner in SW1990 cells.|Products are for research use only. Not for human use.|

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2-Aminobenzenesulfonic acid (Orthanilic acid, O-Aminobenzenesulfonic acid, Aniline-2-sulfonic acid) is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments.|Product information|CAS Number: 88-21-1|Molecular Weight: 173.19|Formula: C6H7NO3S|Chemical Name: 2-aminobenzene-1-sulfonic acid|Smiles: NC1=CC=CC=C1S(O)(=O)=O|InChiKey: ZMCHBSMFKQYNKA-UHFFFAOYSA-N|InChi: InChI=1S/C6H7NO3S/c7-5-3-1-2-4-6(5)11(8,9)10/h1-4H,7H2,(H,8,9,10)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Solubility (25°C).Pritelivir Epigenetic Reader Domain 17 mg/mL(98.PMID:31644131 15 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Physcion 8-O-β-D-glucopyranosideis an anthraquinone compound isolated from Rumex japonicus Houtt. Physcion 8-O-β-D-glucopyranoside exerts anti-inflammatory and anti-cancer properties, can be for common malignancy cancer research.|Product information|CAS Number: 23451-01-6|Molecular Weight: 446.40|Formula: C22H22O10|Chemical Name: 1-hydroxy-6-methoxy-3-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dihydroanthracene-9,10-dione|Smiles: CC1C=C(O)C2=C(C=1)C(=O)C1=CC(=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C1C2=O)OC|InChiKey: POMKXWCJRHNLRP-DQMLXFRHSA-N|InChi: InChI=1S/C22H22O10/c1-8-3-10-15(12(24)4-8)19(27)16-11(17(10)25)5-9(30-2)6-13(16)31-22-21(29)20(28)18(26)14(7-23)32-22/h3-6,14,18,20-24,26,28-29H,7H2,1-2H3/t14-,18-,20+,21-,22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vaborbactam Biological Activity |Shelf Life: ≥12 months if stored properly.Oleclumab custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33082086 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|C-L Xue, et al. Physcion 8-O-β-glucopyranoside exhibits anti-growth and anti-metastatic activities in ovarian cancer by downregulating miR-25.Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5101-5112.Products are for research use only. Not for human use.|

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Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|CAS Number: 1957235-96-9|Molecular Weight: 345.35|Formula: C17H19N3O5|Chemical Name: 4-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione|Smiles: NCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: WPMVPNRNXFIDHY-UHFFFAOYSA-N|InChi: InChI=1S/C17H19N3O5/c18-8-1-2-9-25-12-5-3-4-10-14(12)17(24)20(16(10)23)11-6-7-13(21)19-15(11)22/h3-5,11H,1-2,6-9,18H2,(H,19,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.(1R,3S)-3-Aminocyclopentane carboxylic acid Autophagy |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.Prodigiosin Autophagy PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.PMID:32512976 |References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.Products are for research use only. Not for human use.|