Ined by a SOFA score three.SAvailable on the internet http://ccforum.com/supplements/11/SFigure 1 (abstract P464)*Classified as + if predicted mortality 0.5. Domax, the maximum variety of organ failures during ICU stay.SOFA was defined by TMS minus admission SOFA (SOFAi). The maximum SOFA was defined by the worst SOFA worth during the ICU keep. Logistic regression modeling methods had been made use of to describe the association of derived SOFA variables and SAPS II with mortality. ROC curves had been utilised to assess the model’s discriminatory capability and we examined the model calibration working with the Hosmer emeshow goodness-of-fit test. P < 0.05 was considered significant. Results Diagnostic categories were: trauma 21.3 , postoperative 19 and medical 59.7 . Global mortality was 34.3 . Survivors had lower average SAPS II (28.1 ?14 against 48.6 ?19, P < 0.01), SOFAi score (3.7 ?3 against 7.2 ?4, P < 0.01), SOFAmax score (4.6 ?4 against 10.8 ?3, P < 0.01), SOFA (1.6 ?6 against 4.2 ?3, P < 0.01), DoMAX (1.6 ?6 against 4.2 ?3, P < 0.01) and TMS (5 ?3 against 11.4 ?4, P < 0.01), and the difference was statistically significant. Results regarding model calibration and discriminatory ability are presented in Figure 1. Conclusion The SOFAmax score had the best model calibration and could be used to compare different patient populations in terms of mortality.Results One hundred and seventy-six patients were studied (71 males (56 ), median age 51 (IQR 36?7) years, 78 (44 ) with severe sepsis, median length of ICU stay 10 days (IQR 7?6), median admission SOFA 6 (IQR 4?), median APACHE II score 19 (IQR 13?6), ICU mortality 27.84 (49/176 patients)). The SOFA score and its components scores along the five admission days distinguished the survivors from the nonsurvivors. Considering the SOFA score and its respiratory, neurologic and circulatory components, survivors presented lower scores as the days passed (P < 0.001). Mortality was increasingly higher for those patients who persisted with a SOFA score 7 as the days passed. Conclusion In the sample studied, the persistence of an elevated SOFA score and its components during the first 5 days of admission predicted a higher mortality. Survival PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20800409 seems to be associated with early organ dysfunction recovery. The SOFA score and SOFA-related variables’ day-to-day changes in a population of septic patients could have a crucial prognostic implication and a few patterns of daily evolution may distinguish those sufferers having a extra ominous outcome.P466 Cumulative lactate load correlates with cumulative Sequential Organ Failure Assessment score and survival in intensive care unit patients1GelreP Spronk1, L Brander2, S Jansen1, J Rommes1 Ziekenhuizen Location Lukas, Apeldoorn, The Netherlands; 2University Hospital, Bern, Switzerland Important Care 2007, 11(Suppl 2):P466 (doi: 10.1186/cc5626) Background Adjustments in lactate levels are employed as a prognostic marker in critically ill sufferers. Having said that, the relation involving the time course of get Dabigatran (ethyl ester hydrochloride) arterial blood lactate clearance and vital outcome parameters which include ICU length of remain (LOS), incidence of organ failure and survival price has not been established. Procedures Case records from all ICU patients admitted amongst 2002 and 2004 had been retrospectively identified inside the ICU database. The Sequential Organ Failure Assessment (SOFA) score was calculated each day to assess the time course of organ failure. All lactate levels have been extracted along with the total cumulative lactate load (area beneath the curve above the.