Additional information:
UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication. It is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with IC50 values as low as 20 nM. However, UK 1 is devoid of antimicrobial activity and is inactive against Pseudomonas aeruginosa and Staphylococcus aureus, a methicillin-resistant strain of S. aureus. Additionally, UK-1 can bind a wide variety of di- and tri-valent metal ions, particularly Mg2+ ions, and form complexes with DNA in the presence of Mg2+ ions. Topo II are ATP-dependent enzymes, which can simultaneously cut both strands of the DNA helix to manage DNA supercoils and tangles. In vitro: UK 1 strongly blocked the growth of human epitheloid carcinoma HeLa, mouse melanoma B16, mouse leukemia P388 cells with ED50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.{{Frexalimab} web|{Frexalimab} Apoptosis|{Frexalimab} Purity & Documentation|{Frexalimab} References|{Frexalimab} manufacturer|{Frexalimab} Epigenetic Reader Domain} 11 μg/ml, respectively.{{Tezepelumab (anti-TSLP)} site|{Tezepelumab (anti-TSLP)} Protocol|{Tezepelumab (anti-TSLP)} In Vitro|{Tezepelumab (anti-TSLP)} manufacturer|{Tezepelumab (anti-TSLP)} Autophagy} UK 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml .PMID:23910527 In vivo: Up to now, in vivo study of UK 1 is still in the development stage.|Product information|CAS Number: 151271-53-3|Molecular Weight: 386.36|Formula: C22H14N2O5|Chemical Name: methyl 2-[2-(2-hydroxyphenyl)-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate|Smiles: COC(=O)C1=CC=CC2OC(=NC=21)C1=CC=CC2OC(=NC=21)C1=CC=CC=C1O|InChiKey: NGKIDJMAXLRJRL-UHFFFAOYSA-N|InChi: InChI=1S/C22H14N2O5/c1-27-22(26)14-8-5-11-17-19(14)24-21(29-17)13-7-4-10-16-18(13)23-20(28-16)12-6-2-3-9-15(12)25/h2-11,25H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|