CGP 13501
Product Name :
CGP 13501
Description:
CGP 13501 is a positive allosteric modulator of GABAB receptor . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel. It stimulates the opening of K+ channel and hyperpolarize the neuron. CGP 13501 is a positive allosteric modulator of GABAB receptor. In Chinese hamster ovary (CHO) cell line expressing GABAB(1b/2), CGP 13501 potentiated GABA-stimulated GTPγ[35S] binding to cell membranes . In rat cortex, CGP13501 (10 μM) enhanced GABA-mediated activation of Gαo and increased GTPγ[35S] binding in the presence of GABA. Also, in the hippocampus and cerebellum, CGP13501 increased GABA-induced GTPγ[35S] binding and activation of Gαo. In rat cortex, hippocampus and cerebellum, CGP55845A blocked the influence of CGP13501 on GABA-induced GTPγ[35S] binding at Gαo with pIC50 values of 7.4, 7.31 and 6.82, respectively. In cells expressing GABAB(1b+2) receptors, CGP13501 increased GTPγ[35S] binding at Gαi1/3 .
CAS:
56189-68-5
Molecular Weight:
290.44
Formula:
C19H30O2
Chemical Name:
3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal
Smiles :
CC(C)(C)C1=CC(CC(C)(C)C=O)=CC(=C1O)C(C)(C)C
InChiKey:
XGWATTXMMMANFJ-UHFFFAOYSA-N
InChi :
InChI=1S/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Cimetidine} web|{Cimetidine} GPCR/G Protein|{Cimetidine} Technical Information|{Cimetidine} Purity|{Cimetidine} custom synthesis|{Cimetidine} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CGP 13501 is a positive allosteric modulator of GABAB receptor . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel.{{Nicorandil} web|{Nicorandil} Potassium Channel|{Nicorandil} Technical Information|{Nicorandil} In Vitro|{Nicorandil} supplier|{Nicorandil} Autophagy} It stimulates the opening of K+ channel and hyperpolarize the neuron.PMID:23539298 CGP 13501 is a positive allosteric modulator of GABAB receptor. In Chinese hamster ovary (CHO) cell line expressing GABAB(1b/2), CGP 13501 potentiated GABA-stimulated GTPγ[35S] binding to cell membranes . In rat cortex, CGP13501 (10 μM) enhanced GABA-mediated activation of Gαo and increased GTPγ[35S] binding in the presence of GABA. Also, in the hippocampus and cerebellum, CGP13501 increased GABA-induced GTPγ[35S] binding and activation of Gαo. In rat cortex, hippocampus and cerebellum, CGP55845A blocked the influence of CGP13501 on GABA-induced GTPγ[35S] binding at Gαo with pIC50 values of 7.4, 7.31 and 6.82, respectively. In cells expressing GABAB(1b+2) receptors, CGP13501 increased GTPγ[35S] binding at Gαi1/3 .|Product information|CAS Number: 56189-68-5|Molecular Weight: 290.44|Formula: C19H30O2|Chemical Name: 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal|Smiles: CC(C)(C)C1=CC(CC(C)(C)C=O)=CC(=C1O)C(C)(C)C|InChiKey: XGWATTXMMMANFJ-UHFFFAOYSA-N|InChi: InChI=1S/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|