Additional information:
BIO5192 is a selective and potent integrin α4β1 (VLA-4) inhibitor (KdProduct information|CAS Number: 327613-57-0|Molecular Weight: 817.78|Formula: C38H46Cl2N6O8S|Chemical Name: (2S)-2-{[(2S)-1-(3,5-dichlorobenzenesulfonyl)pyrrolidin-2-yl]formamido}-4-[(2S)-4-methyl-2-[N-methyl-2-(4-{[(2-methylphenyl)carbamoyl]amino}phenyl)acetamido]pentanamido]butanoic acid|Smiles: CN([C@@H](CC(C)C)C(=O)NCC[C@H](NC(=O)[C@@H]1CCCN1S(=O)(=O)C1C=C(Cl)C=C(Cl)C=1)C(O)=O)C(=O)CC1C=CC(=CC=1)NC(=O)NC1=CC=CC=C1C|InChiKey: MNQBPRHHZPXCKZ-ZDCRTTOTSA-N|InChi: InChI=1S/C38H46Cl2N6O8S/c1-23(2)18-33(45(4)34(47)19-25-11-13-28(14-12-25)42-38(52)44-30-9-6-5-8-24(30)3)35(48)41-16-15-31(37(50)51)43-36(49)32-10-7-17-46(32)55(53,54)29-21-26(39)20-27(40)22-29/h5-6,8-9,11-14,20-23,31-33H,7,10,15-19H2,1-4H3,(H,41,48)(H,43,49)(H,50,51)(H2,42,44,52)/t31-,32-,33-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23613863 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|The combination of BIO5192 (1 mg/kg; i.v.) and Plerixafor (5 mg/kg; s.c.) exert an additive effect on progenitor mobilization. BIO5192 (30 mg/kg; s.c; bid; during days 5 through 14) delays paralysis associated with EAE (experimental autoimmune encephalomyelitis). BIO5192 (1 mg/kg, i.v.) shows the terminal half-life is 1.1 hours. BIO5192 (3, 10, and 30 mg/kg; s.c.) shows half-lives of 1.7, 2.7, and 4.7 hours, respectively. The blood plasma curves show that the AUC for the s.c. route of administration increased about 2.5-fold from 5,460 h*ng/ml for the 3 mg/kg dose to 14,175 h*ng/ml for the 30 mg/kg.|Products are for research use only. Not for human use.|