Danger of UC. Folate, a water-soluble B vitamin in green leafy vegetables, citrus NK1 Antagonist manufacturer fruits, and legumes, may be the initial methyl donor in methionine biosynthesis [10]. Folate insufficiency disrupts the transfer in the one-carbon units involved in all biochemical reactions which includes plasma homocysteine determinants and SAM synthesis [11,20]. A preceding study investigated the 10-y trends in plasma folate levels in Taiwanese individuals via three national NAHSIT surveys performed in 199321996, 199922000, and 200522008 and reported similar plasma folate levels of about 8 ng/mL in males and 11 ng/mL in women; nevertheless, the prevalence of folate deficiency (,three ng/mL) enhanced in the course of these 10-y periods, particularly for men [12]. In our study, the median value of plasma folate levels was similar to that reported by Chen et al. but was higher than that reported in other research [12,21,22].Association of DNMT Polymorphism and Folate with the Risk of UCTable 2. Associations involving the levels of plasma folate and UC threat by using multivariate logistic regression models.ORa (95 CI) 1.01 (0.99.03) ref. 2.57 (1.73.84) ref. 0.42 (0.27.65) 0.44 (0.28.68) ref. 0.41 (0.26.68) 0.42 (0.26.68) 0.46 (0.28.75) ORb (95 CI) 1.02 (0.99.04) ref. 2.06 (1.34.15) ref. 0.48 (0.30.76) 0.61 (0.38.97) ref.# 0.46 (0.27.77) 0.49 (0.29.83) 0.66 (0.39.11)Plasma folate (ng/mL) Median six S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 six.75.83 9.834.9 14.9 NUAK1 Inhibitor drug Incidence circumstances Median 6 S.D. .6 #6 ,7.88 7.883.17 13.17 ,6.75 6.75.83 9.834.9 14.9 Prevalence cases Median 6 S.D. .six #6 ,7.88 7.883.17 13.17 ,6.75 6.75.83 9.834.9 14.aUC sufferers N = 192 7.7361.23 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 104 7.2861.33c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31) N = 88 eight.4562.17c 123 (64.06) 69 (35.94) 101 (52.60) 44 (22.92) 47 (24.48) 83 (43.23) 33 (17.19) 37 (19.27) 39 (20.31)Controls N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15) N = 381 9.8260.37 311 (81.63) 70 (18.37) 127 (33.33) 128 (33.60) 126 (33.07) 97 (25.46) 94 (24.67) 98 (25.72) 92 (24.15)0.99 (0.97.02) ref. 3.09 (1.90.01) ref. 0.34 (0.19.61) 0.37 (0.22.65) ref. 0.38 (0.21.71) 0.33 (0.18.62) 0.37 (0.20.68)1.01 (0.99.04) ref. two.43 (1.45.06) ref. 0.40 (0.22.73) 0.53 (0.30.95) ref. 0.44 (0.23.84) 0.39 (0.20.76) 0.53 (0.28.03)1.03 (0.99.05) ref. two.11 (1.24.60) ref. 0.52 (0.29.92) 0.50 (0.27.90) ref.# 0.44 (0.22.00) 0.53 (0.28.00) 0.56 (0.29.08)1.03 (0.99.05) ref. 1.76 (1.01.08) ref. 0.56 (0.31.01) 0.67 (0.36.25) ref. 0.45 (0.23.91) 0.60 (0.31.18) 0.76 (0.38.51)OR values had been adjusted for age and gender. OR values have been adjusted for age, gender, educational level, and cumulative cigarette smoking. p = 0.1772 by Student t-test. p,0.05 by trend test; #0.1,p,0.05 by trend test. doi:10.1371/journal.pone.0104968.tb cMoreover, in our study, the prevalence of folate insufficiency was larger than that in other studies, ranging from 5 to 15 [22]. The differences in the prevalence of folate insufficiency may be attributed towards the ethnic variance of dietary habits or individual susceptibility to polymorphisms in metabolizing folate-related genes for instance DNMT3A and 3B. Prior research have indicated a adverse association amongst plasma.