ds, such as chemical, physical, and bio-based green strategies (sunlight irradiation, from bacteria, fungi, yeast, algae, and plants) [110]. As currently mentioned above, top-down and bottom-up approaches are amongst the easiest. Due to the reality that inorganic nanoparticles are already utilized in diagnostic medicine and imaging, scaling up their production can be a reality, despite the fact that not cost-free from costs. As they consist of a repetition of monomeric interior units encircled by the outermost region, dendrimers are generally synthesized by a sequential repeat of reaction steps. Indeed, they may be formed of a core, from which a variety of spacers depart, whose ends combine using a high degree of branching that allows surface chemistry functionalization with proteins, amino acids, fatty acids, and polymers so as to enhance solubility and reduce toxicity [184,185]. The use of dendrimers as drug carriers continues to be the subject of study, though current applications consist of nanomedicines, CysLT2 Antagonist Accession gene-delivery vectors, biological adhesives, and imaging agents [137,18588]. Finally, SMEDDSs belong to the emulsion class given that they are dry microemulsions without an aqueous phase and they have the wonderful advantage to spontaneously form emulsions in vivo without the need of any power input [86,137]. According to their higher targeting efficiency, it is actually possible to lower the drug amount expected to possess a clinical effect, thereby improving patient compliance and the cost of therapy [137]. Taking these evaluations into account and contemplating the CD30 Inhibitor manufacturer absence of data with regards to some aspects on the newest drug delivery approaches, it can be proper to affirm that nanoemulsions are, at present, by far the most appropriate, well-investigated, and low-cost approach to boost bioavailability of curcumin, either as a drug or possibly a dietary supplement to enrich meals and beverages. 4. Conclusions At the moment, the polyphenolic compound curcumin is among the most investigated organic goods and its useful effects in quite a few human issues happen to be established, together with a low toxic profile. Throughout the years, several curcumin drug targets happen to be described, offering the molecular basis for the pharmacological action. Unfortunately, the bioavailability and delivery of curcumin are the primary obstacles for its effectiveness, precluding the use in medicine. Within this review, we have explored probably the most promising and contemporary techniques for improving curcumin bioavailability, supplying a comprehensive overview with regards to this field. Certainly, the progress in the nanoparticle field could supply, inside the near future, further curcumin-based complexes with considerable pharmacological profiles which will be developed as successful therapeutic agents for treating human diseases. The advancement within this field holds wonderful guarantee to employ this polyphenol in medicine. Additionally, because of the multifunctional profile of curcumin, an efficacious delivery method could offer a much better possibility of productive prophylaxis or treatment in complex multifactorial problems, for instance systemic inflammatory illnesses and cancer, supporting the curcumin-based agents as preventive and disease-modifying therapeutics.Pharmaceutics 2021, 13,29 ofAuthor Contributions: Conceptualization, R.T., S.B. and V.C.; investigation, R.T. and S.B.; data curation, R.T., S.B. and V.C.; writing–original draft preparation, R.T. and S.B.; writing–review and editing, R.T., S.B. and V.C.; supervision, S.B. All authors have read and agreed for the published version with the man