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3-Guanidinopropionic Acid is an AMP-activated protein kinase (AMPK) stimulator and PPARγ coactivator 1α (PGC-1α) activator.{{Fremanezumab} site|{Fremanezumab} Neuronal Signaling|{Fremanezumab} Biological Activity|{Fremanezumab} In stock|{Fremanezumab} supplier|{Fremanezumab} Epigenetics} AMP-activated protein kinase is an enzyme involved in cellular energy homeostasis.{{Abciximab} MedChemExpress|{Abciximab} Integrin|{Abciximab} Technical Information|{Abciximab} Purity|{Abciximab} custom synthesis|{Abciximab} Cancer} AMPK activation has been involved in stimulation of hepatic fatty acid oxidation, ketogenesis, skeletal muscle fatty acid oxidation and glucose uptake, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, and modulation of insulin secretion by pancreatic beta-cells .PMID:23927631 PGC-1α is a transcriptional coactivator involved in regulating the genes implicated in energy metabolism and mitochondrial biogenesis, such as the the expression of AMPK, genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance . 3-Guanidinopropionic acid improved insulin sensitivity and promoted weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). 3-Guanidinopropionic acid was a substrate for both the creatine transporter and creatine kinase . In KKAy mice with noninsulin-dependent diabetes, 3-guanidinopropionic acid decreased the plasma glucose level. In insulin-resistant rhesus monkeys, 3-guanidinopropionic acid increased the disappearance of i.v. glucose .|Product information|CAS Number: 353-09-3|Molecular Weight: 131.13|Formula: C4H9N3O2|Chemical Name: 3-carbamimidamidopropanoic acid|Smiles: NC(=N)NCCC(O)=O|InChiKey: KMXXSJLYVJEBHI-UHFFFAOYSA-N|InChi: InChI=1S/C4H9N3O2/c5-4(6)7-2-1-3(8)9/h1-2H2,(H,8,9)(H4,5,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2-hydroxyFlutamide is an androgen receptor (AR) inhibitor .{{Meropenem} medchemexpress|{Meropenem} Penicillin-binding protein (PBP)|{Meropenem} Biological Activity|{Meropenem} Purity|{Meropenem} manufacturer|{Meropenem} Autophagy} The androgen receptor has been implicated in the development and progression of prostate cancer.{{Vericiguat} MedChemExpress|{Vericiguat} GPCR/G Protein|{Vericiguat} Protocol|{Vericiguat} In stock|{Vericiguat} manufacturer|{Vericiguat} Epigenetics} AR is expressed in many androgen-independent or hormone refractory prostate cancers and is maintained throughout prostate cancer progression.PMID:23996047 Inactivation of AR may delay prostate cancer progression . 2-hydroxyFlutamide is the major metabolite of flutamide generated during the metabolism of the non-steroidal antiandrogen flutamide by CYP1A2 and CYP3A4. Flutamide is an antiandrogenic drug which has been widely used for treatment of prostate cancer. 2-hydroxyflutamide could inhibit flutamide metabolism. In cells, increased conversion of flutamide to 2-hydroxyflutamide or accumulation of 2-hydroxyflutamide may result in the anomalous responses to flutamide, which can be observed in some advanced prostate cancers . 2-hydroxy flutamide blocked the expression of AR target genes and prevented androgen-dependent stabilization of the AR . 2-hydroxyFlutamide was a more powerful antiandrogen in vivo, with higher binding affinity for the AR than flutamide. In humans, hydroxyflutamide exhibited an elimination halflife of about 8 h .|Product information|CAS Number: 52806-53-8|Molecular Weight: 292.21|Formula: C11H11F3N2O4|Chemical Name: 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide|Smiles: CC(C)(O)C(=O)NC1C=C(C(=CC=1)[N+]([O-])=O)C(F)(F)F|InChiKey: YPQLFJODEKMJEF-UHFFFAOYSA-N|InChi: InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 2113-05-5|Molecular Weight: 248.11|Formula: C8H11Cl2N5|Chemical Name: (E)-N”-(3-chlorophenyl)-N-(diaminomethylidene)guanidine hydrochloride|Smiles: Cl.NC(N)=N/C(/N)=N/C1C=C(Cl)C=CC=1|InChiKey: FOWAIJYHRWFTHR-UHFFFAOYSA-N|InChi: InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 1245626-05-4|Molecular Weight: 556.46|Formula: C26H23Cl2N5O3S|Chemical Name: 5-[4-(4-cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-4-methyl-1H-pyrazole-3-carboxamide|Smiles: CC1C(=NN(C=1C1C=CC(=CC=1)C#CCCC#N)C1C=CC(Cl)=CC=1Cl)C(=O)NN1CCS(=O)(=O)CC1|InChiKey: XBHQLFVDGLPBCK-UHFFFAOYSA-N|InChi: InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.{{Cetirizine} site|{Cetirizine} Histamine Receptor|{Cetirizine} Purity & Documentation|{Cetirizine} In Vivo|{Cetirizine} manufacturer|{Cetirizine} Epigenetics} |Product information|CAS Number: 103420-77-5|Molecular Weight: 408.{{Troglitazone} web|{Troglitazone} Autophagy|{Troglitazone} Technical Information|{Troglitazone} Formula|{Troglitazone} manufacturer|{Troglitazone} Cancer} 45|Formula: C25H20N4O2|Chemical Name: N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide|Smiles: CN1C2=CC=CC=C2C(=N[C@H](NC(=O)C2=CC3=CC=CC=C3N2)C1=O)C1C=CC=CC=1|InChiKey: NFHRQQKPEBFUJK-HSZRJFAPSA-N|InChi: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (489.PMID:23543429 66 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Devazepide (oral gavage; 4 mg/kg; twice per day) significantly accelerates cholesterol crystallization and crystal growth to microlithiasis, and the formation of gallstones in mice. Devazepide (intraperitoneal injection; 0.1-1 mg/kg) has opposite effects on spontaneous locomotor activity, and on caerulein- and apomorphine-induced hypomotility in the mouse.|Products are for research use only. Not for human use.|

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WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation.|Product information|CAS Number: 1354825-62-9|Molecular Weight: 415.49|Formula: C23H25N7O|Chemical Name: N-{2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}-3-methylpyridine-2-carboxamide|Smiles: CC1C=CC(=CC=1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)CNC(=O)C1=NC=CC=C1C|InChiKey: ZCZGSEXBXXYQQC-UHFFFAOYSA-N|InChi: InChI=1S/C23H25N7O/c1-14-7-9-16(10-8-14)19-17-20(24)27-13-28-21(17)30(29-19)23(3,4)12-26-22(31)18-15(2)6-5-11-25-18/h5-11,13H,12H2,1-4H3,(H,26,31)(H2,24,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (72.20 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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5′-Guanylic acid disodium salt (5′-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes.|Product information|CAS Number: 5550-12-9|Molecular Weight: 407.PMID:23789847 18|Formula: C10H12N5Na2O8P|Chemical Name: disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate|Smiles: [Na+].[Na+].NC1NC(=O)C2N=CN([C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C=2N=1|InChiKey: PVBRXXAAPNGWGE-LGVAUZIVSA-L|InChi: InChI=1S/C10H14N5O8P.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
2′-Deoxycytidine-5′-monophosphoric acid is an endogenous metabolite.PMID:23074147 |Product information|CAS Number: 1032-65-1|Molecular Weight: 307.20|Formula: C9H14N3O7P|Chemical Name: {[(2R,3S,5R)-3-hydroxy-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid|Smiles: N=C1C=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(O)=N1|InChiKey: NCMVOABPESMRCP-SHYZEUOFSA-N|InChi: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases.{{Domperidone monomaleate} site|{Domperidone monomaleate} Neuronal Signaling|{Domperidone monomaleate} Biological Activity|{Domperidone monomaleate} Purity|{Domperidone monomaleate} supplier|{Domperidone monomaleate} Autophagy} |Product information|CAS Number: 12071-83-9|Molecular Weight: 289.{{Golidocitinib} medchemexpress|{Golidocitinib} JAK/STAT Signaling|{Golidocitinib} Protocol|{Golidocitinib} In Vivo|{Golidocitinib} custom synthesis|{Golidocitinib} Autophagy} 80|Formula: C5H8N2S4Zn|Chemical Name: zinc(2+) ({1-[(sulfanidylmethanethioyl)amino]propan-2-yl}carbamothioyl)sulfanide|Smiles: [Zn+2].PMID:24455443 CC(CNC([S-])=S)NC([S-])=S|InChiKey: KKMLIVYBGSAJPM-UHFFFAOYSA-L|InChi: InChI=1S/C5H10N2S4.Zn/c1-3(7-5(10)11)2-6-4(8)9;/h3H,2H2,1H3,(H2,6,8,9)(H2,7,10,11);/q;+2/p-2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (115.02 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Propineb (Zinc propylenebis) has a moderate to low acute toxicity with a specific goitrogenic effect in rats. long-term exposure, oral or by inhalation is related to carcinogenicity, teratogenicity, malfunction of the reproductive system and malformation of their vitals.|Products are for research use only. Not for human use.|

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T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.{{Lasalocid} web|{Lasalocid} Autophagy|{Lasalocid} Protocol|{Lasalocid} Purity|{Lasalocid} manufacturer|{Lasalocid} Epigenetics} |Product information|CAS Number: 1351927-00-8|Molecular Weight: 327.{{Tebuconazole} site|{Tebuconazole} Cytochrome P450|{Tebuconazole} Protocol|{Tebuconazole} In Vivo|{Tebuconazole} custom synthesis|{Tebuconazole} Autophagy} 36|Formula: C17H18FN5O|Chemical Name: 1-(3-{[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl}phenyl)-2-fluoroethan-1-one|Smiles: CC(C)N1N=C(CC2=CC(=CC=C2)C(=O)CF)C2=C(N)N=CN=C12|InChiKey: WEPKWIAJJGCTLW-UHFFFAOYSA-N|InChi: InChI=1S/C17H18FN5O/c1-10(2)23-17-15(16(19)20-9-21-17)13(22-23)7-11-4-3-5-12(6-11)14(24)8-18/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35116795 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|