Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1; TGFBRAP1 |Host Rabbit |Specificity This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1. |Species Reactivity Human |Applications WB~~1:1000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cancer;Signal Transduction |Target |Background Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. |Cellular localization Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling |UniProt Q8WUH2 |References |References Rose, J. Phd, et al. Mol. Med. (2010) In press :Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.