Additional information:
C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.Zandelisib supplier |Product information|CAS Number: 1784252-84-1|Molecular Weight: 540.57|Formula: C27H43Cl2N5O2|Chemical Name: (4E)-2-[1,4′-bipiperidin]-1′-yl-N-cycloheptyl-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine dihydrochloride|Smiles: Cl.Cl.COC1C=C2/C(/NC(=NC2=CC=1OC)N1CCC(CC1)N1CCCCC1)=N\C1CCCCCC1|InChiKey: GKJKNYQUFAPLOQ-UHFFFAOYSA-N|InChi: InChI=1S/C27H41N5O2.2ClH/c1-33-24-18-22-23(19-25(24)34-2)29-27(30-26(22)28-20-10-6-3-4-7-11-20)32-16-12-21(13-17-32)31-14-8-5-9-15-31;;/h18-21H,3-17H2,1-2H3,(H,28,29,30);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.BIBR 1532 Protocol |Shelf Life: ≥12 months if stored properly.PMID:33179817 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The in vitro oxidative metabolic stability of C-021 (Compound 1b) is evaluated by measuring the rate of drug consumption in human liver microsomes (HML), thus providing intrinsic clearance values (CLint). C-021 exhibits CLint value of 17,377 mL/h/kg.|In Vivo:|The potency of C-021 (Compound 1b) is evident after subcutaneous administration in the murine oxazolone-induced contact hypersensitivity test, a known model of acute skin inflammation. When C-021 is administered orally, however, very little inhibition is observed.|Products are for research use only. Not for human use.|