Product Name :
Varespladib sodium
Description:
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.
CAS:
172733-42-5
Molecular Weight:
402.38
Formula:
C21H19N2NaO5
Chemical Name:
sodium 2-[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxyacetate
Smiles :
CCC1=C(C2=C(C=CC=C2N1CC1C=CC=CC=1)OCC(=O)O[Na])C(=O)C(N)=O
InChiKey:
XZZUHXILQXLTGV-UHFFFAOYSA-M
InChi :
InChI=1S/C21H20N2O5.Na/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13;/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);/q;+1/p-1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.|Product information|CAS Number: 172733-42-5|Molecular Weight: 402.38|Formula: C21H19N2NaO5|Chemical Name: sodium 2-[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxyacetate|Smiles: CCC1=C(C2=C(C=CC=C2N1CC1C=CC=CC=1)OCC(=O)O[Na])C(=O)C(N)=O|InChiKey: XZZUHXILQXLTGV-UHFFFAOYSA-M|InChi: InChI=1S/C21H20N2O5.Na/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13;/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.DMBA medchemexpress |Shelf Life: ≥12 months if stored properly.Muscarine Technical Information |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33214478 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment results in complete inhibition of the RA-induced increase in MUC16 protein detected in cell lysates at both time points. Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment significantly inhibits RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours.|In Vivo:|Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg.|Products are for research use only. Not for human use.|
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