DM3
Product Name :
DM3
Description:
DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).
CAS:
796073-54-6
Molecular Weight:
766.34
Formula:
C37H52ClN3O10S
Chemical Name:
(1S, 2R, 3S, 5S, 6S, 20R, 21S)-11-chloro-21-hydroxy-12, 20-dimethoxy-2, 5, 9, 16-tetramethyl-8, 23-dioxo-4, 24-dioxa-9, 22-diazatetracyclo[19.3.1.1, .0, ]hexacosa-10, 12, 14(26), 16, 18-pentaen-6-yl (2S)-2-(N-methyl-4-sulfanylpentanamido)propanoate
Smiles :
C[C@@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)OC |c:19,t:17|
InChiKey:
LJFFDOBFKICLHN-SVMDFPMXSA-N
InChi :
InChI=1S/C37H52ClN3O10S/c1-20-11-10-12-28(48-9)37(46)19-27(49-35(45)39-37)22(3)33-36(5,51-33)29(50-34(44)23(4)40(6)30(42)14-13-21(2)52)18-31(43)41(7)25-16-24(15-20)17-26(47-8)32(25)38/h10-12,16-17,21-23,27-29,33,46,52H,13-15,18-19H2,1-9H3,(H,39,45)/b12-10-,20-11-/t21?,22-,23+,27+,28-,29+,33+,36+,37+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).|Product information|CAS Number: 796073-54-6|Molecular Weight: 766.{{Ofatumumab} site|{Ofatumumab} Immunology/Inflammation|{Ofatumumab} Technical Information|{Ofatumumab} In Vivo|{Ofatumumab} custom synthesis|{Ofatumumab} Epigenetic Reader Domain} 34|Formula: C37H52ClN3O10S|Synonym:|Maytansinoid DM3|Chemical Name: (1S, 2R, 3S, 5S, 6S, 20R, 21S)-11-chloro-21-hydroxy-12, 20-dimethoxy-2, 5, 9, 16-tetramethyl-8, 23-dioxo-4, 24-dioxa-9, 22-diazatetracyclo[19.{{Afatinib dimaleate} site|{Afatinib dimaleate} MAPK/ERK Pathway|{Afatinib dimaleate} NF-κB|{Afatinib dimaleate} Biological Activity|{Afatinib dimaleate} Data Sheet|{Afatinib dimaleate} manufacturer} 3.1.1, .0, ]hexacosa-10, 12, 14(26), 16, 18-pentaen-6-yl (2S)-2-(N-methyl-4-sulfanylpentanamido)propanoate|Smiles: C[C@@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)OC |c:19,t:17||InChiKey: LJFFDOBFKICLHN-SVMDFPMXSA-N|InChi: InChI=1S/C37H52ClN3O10S/c1-20-11-10-12-28(48-9)37(46)19-27(49-35(45)39-37)22(3)33-36(5,51-33)29(50-34(44)23(4)40(6)30(42)14-13-21(2)52)18-31(43)41(7)25-16-24(15-20)17-26(47-8)32(25)38/h10-12,16-17,21-23,27-29,33,46,52H,13-15,18-19H2,1-9H3,(H,39,45)/b12-10-,20-11-/t21?,22-,23+,27+,28-,29+,33+,36+,37+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32491296 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).Products are for research use only. Not for human use.|