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Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin.|Product information|CAS Number: 82189-04-6|Molecular Weight: 638.79|Formula: C36H50N2O8|Chemical Name: 15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl 2-(cyclohexylformamido)propanoate|Smiles: CC1=CCCC2=CC(O)=CC(NC(=O)CC(C=CC=CC=CCC(OC(=O)C(C)NC(=O)C3CCCCC3)C(C)C1O)OC)=C2O|InChiKey: VVJDHJZQBGWPEQ-QFUIHVKNSA-N|InChi: InChI=1S/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5-,12-7-,18-11-,23-14-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Aldosterone} medchemexpress|{Aldosterone} Endogenous Metabolite|{Aldosterone} Purity & Documentation|{Aldosterone} Description|{Aldosterone} manufacturer|{Aldosterone} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.{{Tropicamide} medchemexpress|{Tropicamide} mAChR|{Tropicamide} Technical Information|{Tropicamide} References|{Tropicamide} custom synthesis|{Tropicamide} Epigenetic Reader Domain} 5 μg/ml, 12.PMID:27217159 5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively. Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM. Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM.|In Vivo:|Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice.|Products are for research use only. Not for human use.|