Additional information:
2-hydroxyFlutamide is an androgen receptor (AR) inhibitor .{{Meropenem} medchemexpress|{Meropenem} Penicillin-binding protein (PBP)|{Meropenem} Biological Activity|{Meropenem} Purity|{Meropenem} manufacturer|{Meropenem} Autophagy} The androgen receptor has been implicated in the development and progression of prostate cancer.{{Vericiguat} MedChemExpress|{Vericiguat} GPCR/G Protein|{Vericiguat} Protocol|{Vericiguat} In stock|{Vericiguat} manufacturer|{Vericiguat} Epigenetics} AR is expressed in many androgen-independent or hormone refractory prostate cancers and is maintained throughout prostate cancer progression.PMID:23996047 Inactivation of AR may delay prostate cancer progression . 2-hydroxyFlutamide is the major metabolite of flutamide generated during the metabolism of the non-steroidal antiandrogen flutamide by CYP1A2 and CYP3A4. Flutamide is an antiandrogenic drug which has been widely used for treatment of prostate cancer. 2-hydroxyflutamide could inhibit flutamide metabolism. In cells, increased conversion of flutamide to 2-hydroxyflutamide or accumulation of 2-hydroxyflutamide may result in the anomalous responses to flutamide, which can be observed in some advanced prostate cancers . 2-hydroxy flutamide blocked the expression of AR target genes and prevented androgen-dependent stabilization of the AR . 2-hydroxyFlutamide was a more powerful antiandrogen in vivo, with higher binding affinity for the AR than flutamide. In humans, hydroxyflutamide exhibited an elimination halflife of about 8 h .|Product information|CAS Number: 52806-53-8|Molecular Weight: 292.21|Formula: C11H11F3N2O4|Chemical Name: 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide|Smiles: CC(C)(O)C(=O)NC1C=C(C(=CC=1)[N+]([O-])=O)C(F)(F)F|InChiKey: YPQLFJODEKMJEF-UHFFFAOYSA-N|InChi: InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|