SNIPER(ER)-110
Product Name :
SNIPER(ER)-110
Description:
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively.
CAS:
2241690-03-7
Molecular Weight:
1122.39
Formula:
C66H83N5O11
Chemical Name:
(2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide
Smiles :
CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1
InChiKey:
DXLPZZKVYXMXOP-UXACQRMVSA-N
InChi :
InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Bintrafusp alfa} web|{Bintrafusp alfa} TGF-β Receptor|{Bintrafusp alfa} Biological Activity|{Bintrafusp alfa} In stock|{Bintrafusp alfa} manufacturer|{Bintrafusp alfa} Cancer}
Additional information:
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker.{{Sulfapyridine} MedChemExpress|{Sulfapyridine} Antibiotic|{Sulfapyridine} Biological Activity|{Sulfapyridine} Data Sheet|{Sulfapyridine} supplier|{Sulfapyridine} Epigenetics} SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of Product information|CAS Number: 2241690-03-7|Molecular Weight: 1122.PMID:23892746 39|Formula: C66H83N5O11|Chemical Name: (2S,4S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]-4-(3-{2-[2-(2-{[(2-{4-[(1Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)(methyl)carbamoyl]methoxy}ethoxy)ethoxy]ethoxy}phenoxy)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrrolidine-2-carboxamide|Smiles: CN(CCOC1C=CC(=CC=1)/C(=C(/CC)\C1C=CC=CC=1)/C1C=CC(O)=CC=1)C(=O)COCCOCCOCCOC1=CC(=CC=C1)O[C@H]1C[C@@H](C(=O)N[C@@H]2CCCC3=CC=CC=C32)N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C1CCCCC1|InChiKey: DXLPZZKVYXMXOP-UXACQRMVSA-N|InChi: InChI=1S/C66H83N5O11/c1-5-57(47-16-8-6-9-17-47)62(49-26-30-52(72)31-27-49)50-28-32-53(33-29-50)80-35-34-70(4)61(73)45-79-39-38-77-36-37-78-40-41-81-54-22-15-23-55(42-54)82-56-43-60(65(75)68-59-25-14-21-48-18-12-13-24-58(48)59)71(44-56)66(76)63(51-19-10-7-11-20-51)69-64(74)46(2)67-3/h6,8-9,12-13,15-18,22-24,26-33,42,46,51,56,59-60,63,67,72H,5,7,10-11,14,19-21,25,34-41,43-45H2,1-4H3,(H,68,75)(H,69,74)/b62-57-/t46-,56-,59+,60-,63-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|