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ALDH1A2-IN-1 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.PMID:31643973 91 μM; Kd=0.26 μM) with several hydrophobic interactions.|Product information|CAS Number: 2204229-64-9|Molecular Weight: 430.52|Formula: C21H26N4O4S|Chemical Name: 1-(3-ethoxythiophene-2-carbonyl)-4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazine|Smiles: CCOC1C=CSC=1C(=O)N1CCN(CC1)C1=CC(=C(C=C1)N(=O)=O)N1CCCC1|InChiKey: LAYJOGOQGVGOCO-UHFFFAOYSA-N|InChi: InChI=1S/C21H26N4O4S/c1-2-29-19-7-14-30-20(19)21(26)24-12-10-22(11-13-24)16-5-6-17(25(27)28)18(15-16)23-8-3-4-9-23/h5-7,14-15H,2-4,8-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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A-674563 is a potent, orally available Akt1 inhibitor with an IC50 value of 11nM.PMID:33358259 Also displays activity against PKA and CDK2 with IC50 values of 16nM and 46nM respectively.|Product information|CAS Number: 552325-73-2|Molecular Weight: 358.44|Formula: C22H22N4O|Chemical Name: (2S)-1-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxy-3-phenylpropan-2-amine|Smiles: CC1NN=C2C=CC(=CC2=1)C1=CN=CC(=C1)OC[C@@H](N)CC1C=CC=CC=1|InChiKey: BPNUQXPIQBZCMR-IBGZPJMESA-N|InChi: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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BET-IN-6 is a potent and high affnity BRD2/BRD4 inhibitor. BET-IN-6 is the ligand for target protein BRD2/4, and is used for the systhesis of PROTAC BRD2/BRD4 degrader-1 (HY-130612).|Product information|Molecular Weight: 440.47|Formula: C22H20N2O6S|Chemical Name: 3-[6-[(2-methoxyphenyl)sulfonylamino]-1-methyl-2-oxobenzo[cd]indol-4-yl]propanoic acid|Smiles: COC1=CC=CC=C1S(=O)(=O)NC1=CC=C2C3=C(C=C(CCC(O)=O)C=C13)C(=O)N2C|InChiKey: OSNRRVBADHGXQL-UHFFFAOYSA-N|InChi: InChI=1S/C22H20N2O6S/c1-24-17-9-8-16(23-31(28,29)19-6-4-3-5-18(19)30-2)14-11-13(7-10-20(25)26)12-15(21(14)17)22(24)27/h3-6,8-9,11-12,23H,7,10H2,1-2H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Idebenone manufacturer |Shelf Life: ≥12 months if stored properly.PMID:32644473 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively.|Product information|CAS Number: 172733-42-5|Molecular Weight: 402.38|Formula: C21H19N2NaO5|Chemical Name: sodium 2-[1-benzyl-3-(carbamoylcarbonyl)-2-ethyl-1H-indol-4-yl]oxyacetate|Smiles: CCC1=C(C2=C(C=CC=C2N1CC1C=CC=CC=1)OCC(=O)O[Na])C(=O)C(N)=O|InChiKey: XZZUHXILQXLTGV-UHFFFAOYSA-M|InChi: InChI=1S/C21H20N2O5.Na/c1-2-14-19(20(26)21(22)27)18-15(9-6-10-16(18)28-12-17(24)25)23(14)11-13-7-4-3-5-8-13;/h3-10H,2,11-12H2,1H3,(H2,22,27)(H,24,25);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.DMBA medchemexpress |Shelf Life: ≥12 months if stored properly.Muscarine Technical Information |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33214478 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment results in complete inhibition of the RA-induced increase in MUC16 protein detected in cell lysates at both time points. Varespladib sodium (10 μM; 24 and 48 hours; HCjE cells) treatment significantly inhibits RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours.|In Vivo:|Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg.|Products are for research use only. Not for human use.|

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Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy.|Product information|CAS Number: 68414-18-6|Molecular Weight: 581.30|Formula: C15H22N5NaO14P2|Chemical Name: sodium (2R,3R,4R)-5-[([(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy(hydroxy)phosphoryl phosphonato)oxy]-2,3,4-trihydroxypentanal|Smiles: [Na+].NC1N=CN=C2C=1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP([O-])(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)[C@@H](O)[C@H]1O|InChiKey: RJWGZGBNLLYUJC-KAXKLPFCSA-M|InChi: InChI=1S/C15H23N5O14P2.Na/c16-13-9-14(18-4-17-13)20(5-19-9)15-12(26)11(25)8(33-15)3-32-36(29,30)34-35(27,28)31-2-7(23)10(24)6(22)1-21;/h1,4-8,10-12,15,22-26H,2-3H2,(H,27,28)(H,29,30)(H2,16,17,18);/q;+1/p-1/t6-,7+,8+,10-,11+,12+,15+;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 125 mg/mL (215.04 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|In mouse embryonic fibroblasts (MEFs), H2O2 treatment demonstrates that the activation of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) produced Adenosine 5′-diphosphoribose (ADP ribose), which is an activating signal for TRPM2 channels, thereby promoting Ca2+ elevation through extracellular Ca2+ influx and (or) lysosomal Ca2+ release.Obefazimod Formula This process eventually activates early or late autophagy in response to different degrees of oxidative stress.PAC web TRPM2 channels are activated by binding of Adenosine 5′-diphosphoribose (ADP ribose) to the intracellular NUDT9-homology (NUDT9-H) domain unique to TRPM2 and located at its C terminus.PMID:33370225 In addition to ADPR, intracellular Ca2+ is an essential coactivator: TRPM2 channels open only in the combined presence of both ligands.|Products are for research use only. Not for human use.|