Dynarrestin
Product Name :
Dynarrestin
Description:
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.
CAS:
2222768-84-3
Molecular Weight:
431.50
Formula:
C22H23F2N3O2S
Chemical Name:
ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate
Smiles :
CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC
InChiKey:
UZNNDDDSGCMQOQ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Larotrectinib} MedChemExpress|{Larotrectinib} Trk Receptor|{Larotrectinib} Purity & Documentation|{Larotrectinib} In Vitro|{Larotrectinib} supplier|{Larotrectinib} Autophagy}
Shelf Life:
≥12 months if stored properly.{{RGB-1} site|{RGB-1} Epigenetics|{RGB-1} Technical Information|{RGB-1} In Vitro|{RGB-1} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23522542
Additional information:
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.|Product information|CAS Number: 2222768-84-3|Molecular Weight: 431.50|Formula: C22H23F2N3O2S|Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate|Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC|InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|