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Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Rabbit polyclonal antibody to GSK3 beta |Synonym Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B |Host Rabbit |Specificity Recognizes endogenous levels of GSK3 beta protein. |Species Reactivity Human, Mouse, Rat, Bovine, Pig, Sheep, Zebrafish |Applications WB 1:500 – 1:1000, IHC 1:50 – 1:200 |Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human GSK3 beta. The exact sequence is proprietary. |Properties |Purification The antibody was purified by immunogen affinity chromatography. |Clonality Polyclonal Antibody |Storage Temp. Shipped at 4 ° C Upon delivery aliquot and store at -20 ° C for one yearAvoid freeze/that cycles |Target |UniProt P49841 | Western blot analysis of GSK3 beta expression in SGC7901 (A), HEK293T (B), HepG2 (C), PC12 (D) whole cell lysates.| Immunohistochemical analysis of GSK3 beta staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. |Tips:This product is for research use only. Not for use in diagnostic prodcedures.

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Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1; TGFBRAP1 |Host Rabbit |Specificity This TGFBRAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human TGFBRAP1. |Species Reactivity Human |Applications WB~~1:1000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Cancer;Signal Transduction |Target |Background Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. |Cellular localization Cytoplasm. Note=Colocalizes with TGF-beta receptors in the absence of signaling |UniProt Q8WUH2 |References |References Rose, J. Phd, et al. Mol. Med. (2010) In press :Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)Hwang, Y., et al. Pharmacogenomics 7(5):697-709(2006)Wurthner, J.U., et al. J. Biol. Chem. 276(22):19495-19502(2001)Provost, P., et al. Proc. Natl. Acad. Sci. U.S.A. 96(5):1881-1885(1999) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.

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Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym RING5; RMA1 |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB 1:500 – 1:2000IHC 1:50 – 1:200IF 1:50 – 1:100 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human RNF5 (NP_008844.1). |Positive control MCF-7,Jurkat,H460,HepG2,U-251MG,Mouse liver,Mouse spleen,Mouse kidney,Rat brain |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. |Cellular localization Endoplasmic reticulum membrane,Membrane,Mitochondrion membrane,Multi-pass membrane protein |UniProt Q99942 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.

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Product Details FAQ Citations(0) Video Pictures Documents |Overview |Description Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |Synonym Myosin light chain kinase family member 4; Sugen kinase 85; SgK085; MYLK4; SGK085 |Host Rabbit |Specificity This MYLK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-314 amino acids from the C-terminal region of human MYLK4. |Species Reactivity Human |Applications WB~~1:1000IHC-P~~1:50~100 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Signal Transduction |Target |UniProt Q86YV6 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.

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Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym MATA2; MATII; SAMS2 |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB 1:500 – 1:2000 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-395 of human MAT2A (NP_005902.1). |Positive control A-549,HeLa,SW620,Mouse lung,Mouse spleen,Rat kidney |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. |UniProt P31153 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.