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D-Mannuronic acid sodium, isolated from Macrocystis pyrifera, has the potential in autoimmune encephalomyelitis (EAE), adjuvant induced arthritis (AIA), nephrotic syndrome, and acute glomerulonephritis studies.{{Benzbromarone} site|{Benzbromarone} Cell Cycle/DNA Damage|{Benzbromarone} Technical Information|{Benzbromarone} Formula|{Benzbromarone} manufacturer|{Benzbromarone} Cancer} |Product information|CAS Number: 921-56-2|Molecular Weight: 216.{{Paeoniflorin} web|{Paeoniflorin} Cell Cycle/DNA Damage|{Paeoniflorin} Technical Information|{Paeoniflorin} Formula|{Paeoniflorin} custom synthesis|{Paeoniflorin} Autophagy} 12|Formula: C6H9NaO7|Chemical Name: sodium (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexanoate|Smiles: [Na+].PMID:23341580 [O-]C(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O|InChiKey: WNFHGZLVUQBPMA-MHFWOIHZSA-M|InChi: InChI=1S/C6H10O7.Na/c7-1-2(8)3(9)4(10)5(11)6(12)13;/h1-5,8-11H,(H,12,13);/q;+1/p-1/t2-,3-,4+,5+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 250 mg/mL (1156.76 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides.{{Ipilimumab} MedChemExpress|{Ipilimumab} Immunology/Inflammation|{Ipilimumab} Protocol|{Ipilimumab} References|{Ipilimumab} custom synthesis|{Ipilimumab} Epigenetics} This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling.Excitation (nm):649, Emission (nm): 670.|Product information|CAS Number: 146368-14-1|Molecular Weight: 753.88|Formula: C37H43N3O10S2|Chemical Name: 1-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-2-[5-(1-ethyl-3,3-dimethyl-5-sulfonato-2,3-dihydro-1H-indol-2-ylidene)penta-1,3-dien-1-yl]-3,3-dimethyl-5-sulfo-3H-indol-1-ium|Smiles: CCN1C(=CC=CC=CC2=[N+](CCCCCC(=O)ON3C(=O)CCC3=O)C3=CC=C(C=C3C2(C)C)S(O)(=O)=O)C(C)(C)C2=CC(=CC=C12)S([O-])(=O)=O|InChiKey: WXWLHDCCGVWTDZ-UHFFFAOYSA-N|InChi: InChI=1S/C37H43N3O10S2/c1-6-38-29-18-16-25(51(44,45)46)23-27(29)36(2,3)31(38)13-9-7-10-14-32-37(4,5)28-24-26(52(47,48)49)17-19-30(28)39(32)22-12-8-11-15-35(43)50-40-33(41)20-21-34(40)42/h7,9-10,13-14,16-19,23-24H,6,8,11-12,15,20-22H2,1-5H3,(H-,44,45,46,47,48,49)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (33.{{SKI II} medchemexpress|{SKI II} Immunology/Inflammation|{SKI II} Biological Activity|{SKI II} Data Sheet|{SKI II} custom synthesis|{SKI II} Epigenetic Reader Domain} 16 mM; Need ultrasonic).PMID:23891445 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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N-Benzyl-N-bis-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.{{Idarubicin} web|{Idarubicin} Cell Cycle/DNA Damage|{Idarubicin} Protocol|{Idarubicin} References|{Idarubicin} custom synthesis|{Idarubicin} Epigenetic Reader Domain} |Product information|CAS Number: 119580-47-1|Molecular Weight: 283.36|Formula: C15H25NO4|Chemical Name: 2-(2-{benzyl[2-(2-hydroxyethoxy)ethyl]amino}ethoxy)ethan-1-ol|Smiles: OCCOCCN(CC1C=CC=CC=1)CCOCCO|InChiKey: HBHHHXUOMCTWCK-UHFFFAOYSA-N|InChi: InChI=1S/C15H25NO4/c17-8-12-19-10-6-16(7-11-20-13-9-18)14-15-4-2-1-3-5-15/h1-5,17-18H,6-14H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:25558565 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1263819-48-2|Molecular Weight: 222.28|Formula: C12H18N2O2|Chemical Name: (2S,4R)-4-amino-5-(4-aminophenyl)-2-methylpentanoic acid|Smiles: C[C@@H](C[C@@H](N)CC1C=CC(N)=CC=1)C(O)=O|InChiKey: JPGXUEFAQWNCEO-GZMMTYOYSA-N|InChi: InChI=1S/C12H18N2O2/c1-8(12(15)16)6-11(14)7-9-2-4-10(13)5-3-9/h2-5,8,11H,6-7,13-14H2,1H3,(H,15,16)/t8-,11+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Linagliptin} site|{Linagliptin} Ferroptosis|{Linagliptin} Technical Information|{Linagliptin} References|{Linagliptin} manufacturer|{Linagliptin} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Tacrolimus} web|{Tacrolimus} FKBP|{Tacrolimus} Purity & Documentation|{Tacrolimus} Purity|{Tacrolimus} manufacturer|{Tacrolimus} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25040798 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

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Fibrin, isolated from bovine blood, is an insoluble protein produced in response to bleeding.{{Anti-Mouse IL-1b Antibody} web|{Anti-Mouse IL-1b Antibody} Interleukin Related|{Anti-Mouse IL-1b Antibody} Protocol|{Anti-Mouse IL-1b Antibody} References|{Anti-Mouse IL-1b Antibody} custom synthesis|{Anti-Mouse IL-1b Antibody} Epigenetics} Fibrin is the major component of the blood clot and is used for coagulation.PMID:25429455 |Product information|CAS Number: 9001-31-4|Molecular Weight: 145.16|Formula: C5H11N3O2|Chemical Name: 2-amino-N-[(methylcarbamoyl)methyl]acetamide|Smiles: CNC(=O)CNC(=O)CN|InChiKey: BWGVNKXGVNDBDI-UHFFFAOYSA-N|InChi: InChI=1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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2,3-Butanedione-2-monoxime is a myosin ATPase inhibitor. Myosin, an ATPase, can convert chemical energy into directed movement and is regarded as a molecular motor. Myosin has various shapes and sizes. More than 11 myosin classes have been identified, and more will be found. The common feature of all of these molecules is a section close to the N terminus, which can be identified as a motor domain. In vitro: 2,3-Butanedione-2-monoxime (BDM), a general probe of myosin function, was widely used in muscle research as a low-affinity but specific chemical phosphatase that could reversibly inhibit the myosin cross-bridge cycle. It was found that wild-type cells treated with BDM at 20 mM for around two generation times were smaller than untreated controls and showed a septation index about twice that observed in the absence of the inhibitor.{{Olanzapine} MedChemExpress|{Olanzapine} Autophagy|{Olanzapine} Purity & Documentation|{Olanzapine} Data Sheet|{Olanzapine} supplier|{Olanzapine} Epigenetics} Moreover, the organization of actin at the cell poles was disorganized in the presence of BDM, however, cells formed a cytokinetic actin ring.{{Treosulfan} site|{Treosulfan} DNA Alkylator/Crosslinker|{Treosulfan} Technical Information|{Treosulfan} Purity|{Treosulfan} manufacturer|{Treosulfan} Epigenetics} In addition, when nitrogen-starved stationary-phase cells were reinoculated into fresh medium in the presence of BDM, the time taken to repolarize the actin cytoskeleton and to resume the characteristic vegetative cell shape were both delayed substantially .PMID:23290930 In vivo: So far, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 57-71-6|Molecular Weight: 101.10|Formula: C4H7NO2|Chemical Name: (3E)-3-(hydroxyimino)butan-2-one|Smiles: C/C(=N\O)/C(C)=O|InChiKey: FSEUPUDHEBLWJY-HWKANZROSA-N|InChi: InChI=1S/C4H7NO2/c1-3(5-7)4(2)6/h7H,1-2H3/b5-3+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 20813-76-7|Molecular Weight: 536.{{Tazarotene} MedChemExpress|{Tazarotene} Autophagy|{Tazarotene} Biological Activity|{Tazarotene} In Vitro|{Tazarotene} supplier|{Tazarotene} Epigenetics} 29|Formula: C10H27N4Na2O16P|Chemical Name: disodium octahydrate [(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-1H-purin-9-yl)oxolan-2-yl]methyl phosphate|Smiles: O.{{Ciprofloxacin} medchemexpress|{Ciprofloxacin} Antibiotic|{Ciprofloxacin} Biological Activity|{Ciprofloxacin} Description|{Ciprofloxacin} manufacturer|{Ciprofloxacin} Epigenetics} O.PMID:36014399 O.O.O.O.O.O.[Na+].[Na+].[O-]P([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CNC2=O|InChiKey: QKWLBOYKTJDMLH-NAGQJCCQSA-L|InChi: InChI=1S/C10H13N4O8P.2Na.8H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;;;;;;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;8*1H2/q;2*+1;;;;;;;;/p-2/t4-,6-,7-,10-;;;;;;;;;;/m1………./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 114289-47-3|Molecular Weight: 393.PMID:24278086 56|Formula: C23H39NO4|Chemical Name: 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide|Smiles: CCCCCCCCCCC(C)(C)C(=O)NC1C(=CC(=CC=1OC)OC)OC|InChiKey: WAFNZAURAWBNDZ-UHFFFAOYSA-N|InChi: InChI=1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer.{{Anti-Mouse IL-1R Antibody} MedChemExpress|{Anti-Mouse IL-1R Antibody} Immunology/Inflammation|{Anti-Mouse IL-1R Antibody} Technical Information|{Anti-Mouse IL-1R Antibody} References|{Anti-Mouse IL-1R Antibody} custom synthesis|{Anti-Mouse IL-1R Antibody} Epigenetic Reader Domain} ,.{{Flucytosine} web|{Flucytosine} Antibiotic|{Flucytosine} Technical Information|{Flucytosine} Description|{Flucytosine} manufacturer|{Flucytosine} Cancer} GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1, an inhibitor of JMJD3.PMID:35991869 GSK-J5 is a pyridine regio-isomer of GSK-J4. Like GSK-J4, this isomer is cell-permeable and hydrolyzed to a free base.3 However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition. Reference: . Agger, K., Cloos, P.A.C., Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nat.Lett. 449(7163), 731-734 (2011). . Hübner, M.R., and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb.Symp.Quant.Biol. 75, 43-49 (2010). . Kruidenier, L., Chung, C.W., Cheng, Z., et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature 488, 404-408 (2012).|Product information|CAS Number: 1394854-51-3|Molecular Weight: 417.50|Formula: C24H27N5O2|Chemical Name: ethyl 3-{[2-(pyridin-3-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate|Smiles: CCOC(=O)CCNC1=CC(=NC(=N1)C1=CN=CC=C1)N1CCC2=CC=CC=C2CC1|InChiKey: LQPGVGSKBNXQDU-UHFFFAOYSA-N|InChi: InChI=1S/C24H27N5O2/c1-2-31-23(30)9-13-26-21-16-22(28-24(27-21)20-8-5-12-25-17-20)29-14-10-18-6-3-4-7-19(18)11-15-29/h3-8,12,16-17H,2,9-11,13-15H2,1H3,(H,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Product information|CAS Number: 29331-92-8|Molecular Weight: 254.28|Formula: C15H14N2O2|Chemical Name: (9R)-9-hydroxy-2-azatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxamide|Smiles: NC(=O)N1C2=CC=CC=C2C[C@@H](O)C2=CC=CC=C12|InChiKey: BMPDWHIDQYTSHX-CQSZACIVSA-N|InChi: InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)/t14-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|