Additional information:
Matrine (Matridin-15-one) is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and u-receptor agonist.|Product information|CAS Number: 519-02-8|Molecular Weight: 248.36|Formula: C15H24N2O|Synonym:|Matridin-15-one|NSC 146051|NSC146051|NSC-146051|Chemical Name: (1R, 2R, 9S, 17S)-7, 13-diazatetracyclo[7.{{DBCO-Biotin} MedChemExpress|{DBCO-Biotin} PROTAC Linkers|{DBCO-Biotin} Epigenetics|{DBCO-Biotin} Protocol|{DBCO-Biotin} In stock|{DBCO-Biotin} manufacturer} 7.1.0, .0, ]heptadecan-6-one|Smiles: O=C1CCC[C@@H]2[C@H]3CCCN4CCC[C@@H](CN12)[C@H]43|InChiKey: ZSBXGIUJOOQZMP-JLNYLFASSA-N|InChi: InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 49 mg/mL(197.29 mM). Water: 11 mg/mLwarmed(44.29 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Guanidine} medchemexpress|{Guanidine} Endogenous Metabolite|{Guanidine} Purity & Documentation|{Guanidine} Formula|{Guanidine} custom synthesis|{Guanidine} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:24605203 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Matrine((+)-Matrine) is an alkaloid found in plants from the Sophora family, which has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor agonist. Matrine significantly inhibites the growth of human non-small cell lung cancer A549 and hepatoma SMMC-7721 cells and induces apoptosis by strongly reducing the viability and the ratio of Bcl-2/Bax protein in A549 cells. matrine may stimulate the descending dynorphinergic neuron, resulting in the stimulation of kappa-opioid receptors (KORs) in the spinal cord, and this phenomenon in turn produces the antinociception in mice.|In Vivo:|LD50: Mice 157mg/kg (i.p.)|References:|Wang XY, et al. Nanfang Yike Daxue Xuebao, 2010, 30(9), 2154-2155.Higashiyama K, et al. Biol Pharm Bull, 2005, 28(5), 845-848.Zhang Y, et al. Cytotechnology, 2009, 59(3), 191-200.Products are for research use only. Not for human use.|