GRL 0617
Product Name :
GRL 0617
Description:
GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro. GRL0617, inhibited SARS-CoV viral replication in Vero E6 cells with an EC(50) of 15 microM and had no associated cytotoxicity. The X-ray structure of PLpro in complex with GRL0617 indicates that the compound has a unique mode of inhibition whereby it binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site.
CAS:
1093070-16-6
Molecular Weight:
304.39
Formula:
C20H20N2O
Chemical Name:
5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
Smiles :
CC1=CC=C(N)C=C1C(=O)N[C@H](C)C1=CC=CC2=CC=CC=C21
InChiKey:
UVERBUNNCOKGNZ-CQSZACIVSA-N
InChi :
InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GRL0617 is a potent, selective and competitive noncovalent inhibitor of SARS PLPro. GRL0617, inhibited SARS-CoV viral replication in Vero E6 cells with an EC(50) of 15 microM and had no associated cytotoxicity. The X-ray structure of PLpro in complex with GRL0617 indicates that the compound has a unique mode of inhibition whereby it binds within the S4-S3 subsites of the enzyme and induces a loop closure that shuts down catalysis at the active site.{{Emtricitabine} MedChemExpress|{Emtricitabine} Endogenous Metabolite|{Emtricitabine} Protocol|{Emtricitabine} Formula|{Emtricitabine} supplier|{Emtricitabine} Epigenetic Reader Domain} |Product information|CAS Number: 1093070-16-6|Molecular Weight: 304.{{Capsaicin} medchemexpress|{Capsaicin} Apoptosis|{Capsaicin} Biological Activity|{Capsaicin} In Vitro|{Capsaicin} supplier|{Capsaicin} Autophagy} 39|Formula: C20H20N2O|Synonym:|GRL-0617|GRL0617|GRL 0617|Chemical Name: 5-Amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide|Smiles: CC1=CC=C(N)C=C1C(=O)N[C@H](C)C1=CC=CC2=CC=CC=C21|InChiKey: UVERBUNNCOKGNZ-CQSZACIVSA-N|InChi: InChI=1S/C20H20N2O/c1-13-10-11-16(21)12-19(13)20(23)22-14(2)17-9-5-7-15-6-3-4-8-18(15)17/h3-12,14H,21H2,1-2H3,(H,22,23)/t14-/m1/s1|Technical Data|Appearance: Solid Power.PMID:35126464 |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Chaudhuri R, Tang S, Zhao G, Lu H, Case DA, Johnson ME. Comparison of SARS and NL63 papain-like protease binding sites and binding site dynamics: inhibitor design implications. J Mol Biol. 2011 Nov 25;414(2):272-88. doi: 10.1016/j.jmb.2011.09.030. Epub 2011 Sep 29. PubMed PMID: 22004941; PubMed Central PMCID: PMC3397151.Nathan J. SchauerRobert S. MaginXiaoxi LiuLaura M. DohertySara J. Buhrlage* Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors. Journal of Medicinal Chemistry, Articles ASAP (Perspective). Publication Date (Web):November 4, 2019DOI: 10.1021/acs.jmedchem.9b01138.Products are for research use only. Not for human use.|