Additional information:
Ciraparantag (free base), also known as PER977, is a small molecule reversal agent for new oral anticoagulants and heparins. PER977 is a water-soluble, cationic molecule that is designed to bind specifically to unfractionated heparin and low-molecular-weight heparin through noncovalent hydrogen bonding and charge–charge interactions.|Product information|CAS Number: 1438492-26-2|Molecular Weight: 512.70|Formula: C22H48N12O2|Synonym:|PER977|PER-977|PER 977|Aripazine|Ciraparantag|Chemical Name: (2S,2’S)-N,N’-(piperazine-1,4-diylbis(propane-3,1-diyl))bis(2-amino-5-guanidinopentanamide)|Smiles: NC(=N)NCCC[C@H](N)C(=O)NCCCN1CCN(CC1)CCCNC(=O)[C@@H](N)CCCNC(N)=N|InChiKey: HRDUUSCYRPOMSO-ROUUACIJSA-N|InChi: InChI=1S/C22H48N12O2/c23-17(5-1-7-31-21(25)26)19(35)29-9-3-11-33-13-15-34(16-14-33)12-4-10-30-20(36)18(24)6-2-8-32-22(27)28/h17-18H,1-16,23-24H2,(H,29,35)(H,30,36)(H4,25,26,31)(H4,27,28,32)/t17-,18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Dzik WH. Reversal of oral factor Xa inhibitors by prothrombin complex concentrates: a re-appraisal. J Thromb Haemost. 2015 Jun;13 Suppl 1:S187-94. doi: 10.1111/jth.12949. PubMed PMID: 26149022.Crowther M, Crowther MA. Antidotes for Novel Oral Anticoagulants: Current Status and Future Potential.{{Nimodipine} MedChemExpress|{Nimodipine} Membrane Transporter/Ion Channel|{Nimodipine} Purity & Documentation|{Nimodipine} Data Sheet|{Nimodipine} supplier|{Nimodipine} Cancer} Arterioscler Thromb Vasc Biol.{{Biotin-PEG4-NHS ester} web|{Biotin-PEG4-NHS ester} PROTAC Linkers|{Biotin-PEG4-NHS ester} TGF-beta/Smad|{Biotin-PEG4-NHS ester} Technical Information|{Biotin-PEG4-NHS ester} References|{Biotin-PEG4-NHS ester} custom synthesis} 2015 Aug;35(8):1736-45.PMID:28739548 doi: 10.1161/ATVBAHA.114.303402. Epub 2015 Jun 18. PubMed PMID: 26088576.Sullivan DW Jr, Gad SC, Laulicht B, Bakhru S, Steiner S. Nonclinical Safety Assessment of PER977: A Small Molecule Reversal Agent for New Oral Anticoagulants and Heparins. Int J Toxicol. 2015 Jun 15. pii: 1091581815590667. [Epub ahead of print] PubMed PMID: 26079256.Mo Y, Yam FK. Recent advances in the development of specific antidotes for target-specific oral anticoagulants. Pharmacotherapy. 2015 Feb;35(2):198-207. doi: 10.1002/phar.1532. Epub 2015 Feb 3. PubMed PMID: 25644580.Yates SW. Interrupting anticoagulation in patients with nonvalvular atrial fibrillation. P T. 2014 Dec;39(12):858-80. PubMed PMID: 25516695; PubMed Central PMCID: PMC4264672.Products are for research use only. Not for human use.|