he synthesis of supramolecular structures [6]. Supramolecular structures are formed through various elements interacting with non-covalent interactions including hydrogen bonding [70], dipole-dipole interactions, steric repulsions, van der Waals interactions, and London dispersion forces. These non-covalent interactions are significant for biological sysCorresponding authors. E-mail addresses: fozturkkan36@gmail, [email protected] (F.E. t kkan), [email protected] (M. Sert lik).tems also as contribute towards the stability of the crystal structure [115]. Cobalt can be a bio-metal identified in plants, human and animal metabolisms. In humans, cobalt is in the center of cobalamin (vitamin B12), which can be vital for many physiological processes for instance DNA synthesis and also the proper functioning of the nervous system. Cobalt complexes are recognized for their anticancer and antimicrobial properties. Current study has focused on the synthesis and evaluation of complexes with biologically interesting ligands to enhance complicated activity [168]. Zinc is the second most abundant trace element in the human physique. Approximately 95 from the zinc within the human body is inside the cell. It is essential for development and development in all types of life. In case of each deficiency and excess, it causes some overall health difficulties. It has been recommended to possess effective therapeutic and preventive effects on infectious diseases, including shortening the duration of your frequent cold for humans [17,191]. Apart from its vital role in living systems, the zinc (II) ion is usually a element of compounds utilized medicinally inside the remedy of skin diseases and as a nutritional supplement. Zinc(II) complexes are known to become used as antimicrobial [22], antifungal [23], anticancer [24], anti-inflammatory [25], antioxidant [26] and antidiabetic [27] agents.doi.org/10.1016/j.molstruc.2021.131825 0022-2860/2021 Elsevier B.V. All rights reserved.F.E. t kkan, M. demir, G.B. Akbaba et al.Journal of Molecular Structure 1250 (2022)The illness COVID19, which emerged with all the spread of a new Coronavirus known as SARS-Cov-2 in late 2019, brought on a worldwide pandemic and brought most activities in the world to a standstill. Using the pandemic, people had to take some disposable precautions, including masks, visors, overalls, together with the guidance of some authorities. Numerous researchers continue to operate for both remedy and permanent prevention [280]. These days, drug components synthesized for use in drug therapy for many viral diseases like Herpes and HIV are limited. This Topoisomerase manufacturer really is also accurate for SARS-CoV-2 [313]. Though some of the known drugs employed within the remedy of SARSCoV-2 because the beginning in the pandemic are still in use, the use of a few of them has been stopped [34]. We wanted to help with an in silico study no matter whether two compounds synthesized for the first time in this study can be antiviral agent candidates for use in the treatment of SARS-CoV-2. two. Components and method 2.1. Chemical compounds All chemical compounds and solvents were purchased commercially and used without the need of further purification. Sodium bicarbonate, 2-chlorobenzoic acid, 3-cyanopyridine, ethanol, plus the metal salts CoSO4 H2 O and ZnSO4 H2 O had been obtained from Sigma Aldrich, Germany. two.2. Measurements FT-IR spectra have been recorded within the range of 60 00 0 0 cm-1 with a Perkin Elmer FrontierTM spectrometer with an ATR detector utilizing solid samples. 1 H NMR spectrum of the complex two was recorded on Bruker PKD2 Synonyms Avance III 500 spectrometer in deuterated DMSO (d6 -DMSO