ile according to Gupta and Kumar [112], 30 idiopathic infertile guys presented using a 53 raise in sperm concentration following consumption of 2 mg/day LYC for three months.Molecules 2021, 26, x FOR PEER REVIEW11 ofMolecules 2021, 26,concentration, though in line with Gupta and Kumar [112], 30 idiopathic infertile menof 40 11 presented having a 53 increase in sperm concentration following consumption of 2 mg/day LYC for three months.Figure 3. Most often reported beneficial effects of lycopene on spermatogenesis, sperm structural Figure three. Most regularly reported beneficial effects of lycopene on spermatogenesis, sperm strucintegrity and functional activity. tural integrity and functional activity.In their study, Yamamoto et al. [109] revealed that infertile sufferers who consumed In their study, Yamamoto et al. [109] revealed that infertile sufferers who consumed tomato juice (containing 30 mg LYC) for 12 weeks, presented using a significantly decreased tomato juice (containing 30 mg LYC) for 12 weeks, presented with a considerably dethe concentration of seminal leukocytes suggesting a lower danger for inflammation and creased the concentration of seminal leukocytes suggesting a reduce danger for inflammation sperm harm as a result of leukocytospermia. Additionally, the motility rates had been signifand sperm harm because of leukocytospermia. In addition, the motility rates had been icantly higher in the experimental group in 15-LOX Compound comparison with all the handle indicating that substantially higher in the experimental group in comparison with the control indicating commercially accessible meals, for instance tomato juice, could possibly be helpful to counteract male that commercially out there meals, such as tomato juice, might be beneficial to counteract infertility. male infertility. Quite a few clinical trials also focused on the antioxidant properties of LYC in the FGFR2 web context of Many clinical trials also focused on the antioxidant properties et al. [113] observed oxidative stress-compromised male reproductive function. Filipcikovaof LYC in the context of oxidativedecrease of MDA production in the seminal plasma of infertile menal. [113] oba substantial stress-compromised male reproductive function. Filipcikova et consuming served a significant decrease of MDA production in emphasized on the of infertile males 10 mg of highly purified LYC from tomato puree plus the seminal plasma efficacy of LYC consuming ten mg of highly purified LYC from tomato puree and emphasized around the Tain stabilizing the levels of polyunsaturated fatty acids inside the sperm membranes. effis cacy [114] speculated that this LPO-preventing potential lies inside the the sperm memet al. of LYC in stabilizing the levels of polyunsaturated fatty acids inability of LYC to branes. Ta et al. [114] speculated that this of membranous potential lies inside the potential of grow to be entrapped in the hydrophobic core LPO-preventing constituents in spermatozoa. LYC to become entrapped in the hydrophobic core of membranous constituents in sperMoreover, LPO was reportedly decreased by consuming tomato juice fortified with vitamin matozoa. Furthermore, LPO the reportedly lowered by consuming tomato juice fortified C for 2 weeks [115], exactly where wasauthors putatively speculated that vitamin C could have with within a synergy with LYC present inside the tomato juice. Interestingly, while decrease acted vitamin C for two weeks [115], exactly where the authors putatively speculated thatavitamin C could possibly have acted in a synergy together with the GPx activity the tomato juice. In