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The aim of this short critique will be to trigger a far more important evaluation of scientific proof existing in literature on potential hepatotoxicity of Curcuma longa. The revision of sources would be against the most recent trend that blames this well-known spice extensively made use of for centuries. Curcuma longa has been made use of throughout human history for numerous purposes on account of its wide array of biological activity (Sharifi-Rad et al., 2020). Curcumin was identified to be the major active component from the extract in the rhizome, called turmeric. Curcumin would be the ingredient responsible for the effects of turmeric as a drug in its long history of use in traditional Asian medicine for a wide variety of issues. The Compendium of Sushruta, the foundational text of Ayurveda dating to 250 BCE (Joshi et al., 2017), recommends an ointment containing turmeric, Curcuma longa κ Opioid Receptor/KOR Storage & Stability powdered, to relieve the effects of poisoned meals. It is actually not surprising, as a result, that curcumin is at the moment sold as a dietary supplement and that quite a few clinical trials are ongoing to evaluate curcumin activity. Inside the last decade a large variety of reports happen to be published around the useful effects of curcumin (Barchitta et al., 2019) and it has been repeatedly claimed that this natural product is effective and secure for the prevention and treatment of quite a few diseases (Abd El-Hack et al., 2021). Furthermore, curcumin has been widely studied for its antioxidant, anti-inflammatory, and wound-healing effects (Menon and Sudheer, 2007; Shirban et al., 2021). This natural polyphenol is thought of by some authors as a “wonder drug of life” (Gera et al., 2017) and it truly is categorized as a “generally recognized as safe” (GRAS) material, with a steady metabolism and low toxicity (Nelson et al., 2017). More than recent years, meals supplements containing Curcuma longa have been broadly made use of by an growing number of consumers and there is certainly accumulating evidence that curcumin may not be so productive and safe. Quite a few reports have already been issued that described the circumstances of hugely probable drug-induced autoimmune hepatitis (DIAIH) ascribed to ingestion of Curcuma longa dietary supplement (Philips et al., 2020). That may be, in contrast with the use, considering that ancient occasions, of Curcuma longa, as hepatoprotective (Rahmani et al., 2016; Tung et al., 2017; Peng et al., 2018) and for the remedy of digestive tract problems (Gera et al., 2017). Additionally, in literature it really is reported that curcumin may well prevent oxidative stress-related liver disorder causing a series of metabolic reactions as i) decreasing the levels of alanine transaminase (ALT), aspartase transaminase (AST), and alkaline phosphatase (ALP). ii) It PLD Source increases the expression of glutathione-S-transferase (GST), glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) even though additional iii) minimizing NO production and inhibiting ROS formation (Farzaei et al., 2018). Essentially the most typical substance related with Curcuma longa in its use as food supplement is piperine from Piper nigrum L. Black pepper (Piper nigrum L.) may be the most employed specie of pepper and it has found a worldwide use as a spice. Its history of use in traditional medicine is thousands of years old, getting described in Ayurvedic medicine treatie