Merous applications of AgNPs, a great quantity of studies have reported the antioxidant properties of green synthesized AgNPs in the final decade. In general, contradictory final results may be discovered in preceding research around the antioxidant properties of AgNPs and extracts. Because of the occurrence of phytochemicals inside the extract, they showed superior scavenging activity than AgNPs. Chinese herbal medicines contain a diverse array of cost-free radical scavenging molecules, including phenolic acid, flavonoids, terpenoids, and numerous other endogenous metabolites with antioxidant properties. The antioxidant activity may be attributed to the phenolic contents as a result of their redox properties, which enable them to act as 3-Chloro-5-hydroxybenzoic acid Autophagy reducing agents, hydrogen donors, and singlet oxygen quenchers. Green synthesized AgNPs as a novel therapeutic would be crucial inside a selection of biomedical applications [134]. AgNPs mediated by Leptadenia reticulata leaf extract enhanced two,2 diphenyl-1-picrylhydrazyl (DPPH) cost-free radical scavenging activity. In comparison to previous studies, the highest totally free radical scavenging activity of AgNPs synthesized fromNanomaterials 2021, 11,15 ofLeptadenia reticulate leaf extract was 64.81 at a concentration of 500 mg/mL [166], which may be connected to their capability to JPH203 Biological Activity donate hydrogen and electron absorption inside the presence of lipophilic absolutely free radicals. A related conclusion was reached when AgNPs had been synthesized from Cibotium barometz root extract, a Chinese herb referred to as “Gouji” in China [167]. AgNPs had been found to exhibit powerful antibacterial and antioxidant activity. To summarize, caffeic acids, protocatechuic acid (dihydroxybenzoic acid), fatty acid, and flavonoids all contribute considerably to ameliorate the antioxidant activity of AgNPs. Caffeic acid and diterpenoid extract from Saliva plants are applied in folk medicines and exhibit antioxidant and anti-diabetic properties [168]. The antioxidant activity of Elephantopus scaber extract and AgNPs was evaluated, DPPH radical scavenging potential enhanced within a dose-dependent manner. The results revealed that the lowest concentration of AgNPs 50 /mL scavenging capability was 15.23 0.04 and this antioxidant activity was improved to 85.90 0.08 , when AgNP concentration increased to 250 /mL [169]. Previously, AgNPs synthesized from garlic, green tea, and turmeric extracts showed prospective antioxidants properties. These extracts include a high concentration of bioactive elements, specially polyphenols, and act as a reducing and capping agent for AgNPs [21]. These antioxidant compounds have been reported in epidemiological research to possess anti-inflammatory, anticancer, and antibacterial or antiviral activity [170]. One more study examined the ethnopharmacology and antioxidant activity of 12 Chinese herbs [74]. Carthamus tinctorius, referred to as safflower in China, is usually a medicinal herb from which 104 compounds happen to be isolated and identified [85]. Simply because ROS are broadly believed to play a function in establishing quite a few illnesses, safflower should possess a effective impact on cancer therapy. Scutellaria baicalensis (Huang-Qin) is a Chinese herb that contains flavones including baicalin, wogonin, and aglycones. The characterization of biosynthesized AgNPs from S. baicalensis aqueous extract revealed its antioxidant activity against DPPH [97]. DPPH is usually a stable, totally free radical scavenging organic chemical compound useful within the screening of antioxidants. Because of this, the antioxidant activity of various Chinese herbal an.