Bral edema in stroke-prone rats: a magnetic resonance imaging study. Stroke 29: 167174. 28. Attia DM, Ni ZN, Boer P, Attia MA, Goldschmeding R, et al. Proteinuria is preceded by decreased nitric oxide synthesis and prevented by a NO donor in cholesterol-fed rats. Kidney Int 61: 17761787. 29. Racasan S, Joles JA, Boer P, Koomans HA, Braam B NO dependency of RBF and autoregulation in the spontaneously hypertensive rat. Am J Physiol Renal Physiol 285: F105F112. 30. Patel K, Chen Y, Dennehy K, Blau J, Connors S, et al. Acute antihypertensive action of nitroxides within the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 290: R37R43. 31. Wilcox CS, Pearlman A Chemistry and antihypertensive effects of 498-02-2 web tempol along with other nitroxides. Pharmacol Rev 60: 418469. 32. Knight SF, Yuan J, Roy S, Imig JD Simvastatin and tempol guard against endothelial dysfunction and renal injury within a model of obesity and hypertension. Am J Physiol Renal Physiol 298: F86F94. 33. Moreno JM, Rodriguez G, I, Wangensteen R, Osuna A, Bueno P, et al. Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Am J Physiol Endocrinol Metab 289: E776E783. 34. Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats. Am J Physiol Regul Integr Comp Physiol 294: R1847R1855. 35. van Koppen A., Joles JA, Bongartz LG, van den Brandt J., Reichardt HM, et al. Healthier bone marrow cells lower progression of kidney failure much better than CKD bone marrow cells in rats with established chronic kidney illness. Cell Transplant 21: 22992312. 36. Mulder J, Hokfelt T, Knuepfer MM, Kopp UC Renal sensory and sympathetic nerves reinnervate the kidney inside a similar time-dependent style immediately after renal denervation in rats. Am J Physiol Regul Integr Comp Physiol 304: buy CP21 R675R682. 37. Tanaka T, Nangaku M Angiogenesis and hypoxia in the kidney. Nat Rev Nephrol 9: 211222. 38. Hasselwander O, Young IS Oxidative pressure in chronic renal failure. No cost Radic Res 29: 111. 39. Martin-Mateo MC, Sanchez-Portugal M, Iglesias S, de PA, Bustamante J Oxidative stress in chronic renal failure. Ren Fail 21: 155167. 40. Mimic-Oka J, Simic T, Djukanovic L, Reljic Z, Davicevic Z Alteration in plasma antioxidant capacity in various degrees of chronic renal failure. Clin Nephrol 51: 233241. 41. Sindhu RK, Ehdaie A, Farmand F, Dhaliwal KK, Nguyen T, et al. Expression of catalase and glutathione peroxidase in renal insufficiency. Biochim Biophys Acta 1743: 8692. 42. Vaziri ND, Rodriguez-Iturbe B Mechanisms of illness: oxidative strain and inflammation within the pathogenesis of hypertension. Nat Clin Pract Nephrol 2: 582593. 43. Erdei N, Bagi Z, Edes I, Kaley G, Koller A H2O2 increases production of constrictor prostaglandins in smooth muscle major to enhanced arteriolar tone in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol 292: H649H656. 44. Gao YJ, Lee RM Hydrogen peroxide is definitely an endothelium-dependent contracting aspect in rat renal artery. Br J Pharmacol 146: 10611068. 9 Hypertension in CKD Will not Depend on ROS 45. Savage T, McMahon AC, Mullen AM, Nott CA, Dodd SM, et al. Improved myogenic tone precedes structural changes in mild experimental uraemia inside the absence of hypertension in rats. Clin Sci 95: 681686. 46. Vettoretti S, Ochodnicky P, Buikema H, Henning RH, Kluppel CA, et al. Altered myogenic constriction and e.Bral edema in stroke-prone rats: a magnetic resonance imaging study. Stroke 29: 167174. 28. Attia DM, Ni ZN, Boer P, Attia MA, Goldschmeding R, et al. Proteinuria is preceded by decreased nitric oxide synthesis and prevented by a NO donor in cholesterol-fed rats. Kidney Int 61: 17761787. 29. Racasan S, Joles JA, Boer P, Koomans HA, Braam B NO dependency of RBF and autoregulation inside the spontaneously hypertensive rat. Am J Physiol Renal Physiol 285: F105F112. 30. Patel K, Chen Y, Dennehy K, Blau J, Connors S, et al. Acute antihypertensive action of nitroxides inside the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol 290: R37R43. 31. Wilcox CS, Pearlman A Chemistry and antihypertensive effects of tempol and also other nitroxides. Pharmacol Rev 60: 418469. 32. Knight SF, Yuan J, Roy S, Imig JD Simvastatin and tempol shield against endothelial dysfunction and renal injury within a model of obesity and hypertension. Am J Physiol Renal Physiol 298: F86F94. 33. Moreno JM, Rodriguez G, I, Wangensteen R, Osuna A, Bueno P, et al. Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Am J Physiol Endocrinol Metab 289: E776E783. 34. Koeners MP, Braam B, van der Giezen DM, Goldschmeding R, Joles JA A perinatal nitric oxide donor increases renal vascular resistance and ameliorates hypertension and glomerular injury in adult fawn-hooded hypertensive rats. Am J Physiol Regul Integr Comp Physiol 294: R1847R1855. 35. van Koppen A., Joles JA, Bongartz LG, van den Brandt J., Reichardt HM, et al. Wholesome bone marrow cells minimize progression of kidney failure better than CKD bone marrow cells in rats with established chronic kidney illness. Cell Transplant 21: 22992312. 36. Mulder J, Hokfelt T, Knuepfer MM, Kopp UC Renal sensory and sympathetic nerves reinnervate the kidney in a similar time-dependent style after renal denervation in rats. Am J Physiol Regul Integr Comp Physiol 304: R675R682. 37. Tanaka T, Nangaku M Angiogenesis and hypoxia within the kidney. Nat Rev Nephrol 9: 211222. 38. Hasselwander O, Young IS Oxidative stress in chronic renal failure. Free Radic Res 29: 111. 39. Martin-Mateo MC, Sanchez-Portugal M, Iglesias S, de PA, Bustamante J Oxidative pressure in chronic renal failure. Ren Fail 21: 155167. 40. Mimic-Oka J, Simic T, Djukanovic L, Reljic Z, Davicevic Z Alteration in plasma antioxidant capacity in several degrees of chronic renal failure. Clin Nephrol 51: 233241. 41. Sindhu RK, Ehdaie A, Farmand F, Dhaliwal KK, Nguyen T, et al. Expression of catalase and glutathione peroxidase in renal insufficiency. Biochim Biophys Acta 1743: 8692. 42. Vaziri ND, Rodriguez-Iturbe B Mechanisms of disease: oxidative anxiety and inflammation inside the pathogenesis of hypertension. Nat Clin Pract Nephrol 2: 582593. 43. Erdei N, Bagi Z, Edes I, Kaley G, Koller A H2O2 increases production of constrictor prostaglandins in smooth muscle top to enhanced arteriolar tone in Kind two diabetic mice. Am J Physiol Heart Circ Physiol 292: H649H656. 44. Gao YJ, Lee RM Hydrogen peroxide is an endothelium-dependent contracting aspect in rat renal artery. Br J Pharmacol 146: 10611068. 9 Hypertension in CKD Does not Rely on ROS 45. Savage T, McMahon AC, Mullen AM, Nott CA, Dodd SM, et al. Enhanced myogenic tone precedes structural changes in mild experimental uraemia in the absence of hypertension in rats. Clin Sci 95: 681686. 46. Vettoretti S, Ochodnicky P, Buikema H, Henning RH, Kluppel CA, et al. Altered myogenic constriction and e.