Proton-pump inhibitor proton-pump.com

Additional information:
Physcion 8-O-β-D-glucopyranosideis an anthraquinone compound isolated from Rumex japonicus Houtt. Physcion 8-O-β-D-glucopyranoside exerts anti-inflammatory and anti-cancer properties, can be for common malignancy cancer research.|Product information|CAS Number: 23451-01-6|Molecular Weight: 446.40|Formula: C22H22O10|Chemical Name: 1-hydroxy-6-methoxy-3-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dihydroanthracene-9,10-dione|Smiles: CC1C=C(O)C2=C(C=1)C(=O)C1=CC(=CC(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C1C2=O)OC|InChiKey: POMKXWCJRHNLRP-DQMLXFRHSA-N|InChi: InChI=1S/C22H22O10/c1-8-3-10-15(12(24)4-8)19(27)16-11(17(10)25)5-9(30-2)6-13(16)31-22-21(29)20(28)18(26)14(7-23)32-22/h3-6,14,18,20-24,26,28-29H,7H2,1-2H3/t14-,18-,20+,21-,22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vaborbactam Biological Activity |Shelf Life: ≥12 months if stored properly.Oleclumab custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33082086 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|C-L Xue, et al. Physcion 8-O-β-glucopyranoside exhibits anti-growth and anti-metastatic activities in ovarian cancer by downregulating miR-25.Eur Rev Med Pharmacol Sci. 2019 Jun;23(12):5101-5112.Products are for research use only. Not for human use.|

Additional information:
Thalidomide-O-C4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.|Product information|CAS Number: 1957235-96-9|Molecular Weight: 345.35|Formula: C17H19N3O5|Chemical Name: 4-(4-aminobutoxy)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione|Smiles: NCCCCOC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: WPMVPNRNXFIDHY-UHFFFAOYSA-N|InChi: InChI=1S/C17H19N3O5/c18-8-1-2-9-25-12-5-3-4-10-14(12)17(24)20(16(10)23)11-6-7-13(21)19-15(11)22/h3-5,11H,1-2,6-9,18H2,(H,19,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.(1R,3S)-3-Aminocyclopentane carboxylic acid Autophagy |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.Prodigiosin Autophagy PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.PMID:32512976 |References:|Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.Products are for research use only. Not for human use.|

Additional information:
LDV, a non-fluorescent derivative of LDV FITC, is a α4β1 integrin (VLA-4) ligand (Kd ~ 12 nM).|Product information|CAS Number: 1155866-55-9|Molecular Weight: 979.13|Formula: C48H70N10O12|Chemical Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-4-methyl-2-[[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]acetyl]amino]pentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]propanoyl]amino]hexanoic acid|Smiles: CC1=CC=CC=C1NC(=O)NC1C=CC(CC(=O)NC(CC(C)C)C(=O)NC(CC(O)=O)C(=O)NC(C(C)C)C(=O)N2CCCC2C(=O)NC(C)C(=O)NC(C)C(=O)NC(CCCCN)C(O)=O)=CC=1|InChiKey: FQYZPSNPTJYQKB-UHFFFAOYSA-N|InChi: InChI=1S/C48H70N10O12/c1-26(2)23-35(53-38(59)24-31-17-19-32(20-18-31)52-48(70)56-33-14-9-8-13-28(33)5)43(64)55-36(25-39(60)61)44(65)57-40(27(3)4)46(67)58-22-12-16-37(58)45(66)51-29(6)41(62)50-30(7)42(63)54-34(47(68)69)15-10-11-21-49/h8-9,13-14,17-20,26-27,29-30,34-37,40H,10-12,15-16,21-25,49H2,1-7H3,(H,50,62)(H,51,66)(H,53,59)(H,54,63)(H,55,64)(H,57,65)(H,60,61)(H,68,69)(H2,52,56,70)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Camoteskimab Purity & Documentation |Shelf Life: ≥12 months if stored properly.Pritelivir Protocol |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32954954 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Ben H Njus, et al. Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev Technol. 2009 Oct;7(5):507-15.Estelle Gerard, et al. LDV peptidomimetics equipped with biotinylated spacer-arms: synthesis and biological evaluation on CCRF-CEM cell line. Bioorg Med Chem Lett. 2012 Jan 1;22(1):586-90.Products are for research use only. Not for human use.|

Additional information:
CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems.|Product information|CAS Number: 2279062-54-1|Molecular Weight: 1612.98|Formula: C84H122FN9O19S|Chemical Name: 3-(3-[(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-9,24-dihydrogenio-1,14-dihydroxy-12-[(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-2,3,10,16-tetraoxo-11,28-dioxa-4-azatricyclo[22.3.1.0⁴,⁹]octacos-18-en-17-yl]propylsulfanyl)-N-(2-2-[2-(2-4-[(4-2-[5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-1,3-benzodiazol-2-yl]ethyl-2-fluorophenoxy)methyl]-1H-1,2,3-triazol-1-ylethoxy)ethoxy]ethoxyethyl)propanamide|Smiles: C/C(=C\[C@H]1C[C@@H](OC)[C@H](O)CC1)/[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)CC(C)=C[C@@H](CCCSCCC(=O)NCCOCCOCCOCCN3C=C(COC4=CC=C(CCC5=NC6=CC(=CC=C6N5CCN5CCOCC5)C5=C(C)ON=C5C)C=C4F)N=N3)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC |t:38||InChiKey: JPTHTRDMYPXUQU-RUIZCASWSA-N|InChi: InChI=1S/C84H122FN9O19S/c1-53-42-54(2)44-74(104-9)80-75(105-10)46-56(4)84(102,112-80)81(99)82(100)94-26-12-11-15-68(94)83(101)111-79(55(3)45-61-16-21-69(95)73(48-61)103-8)57(5)70(96)50-71(97)62(43-53)14-13-40-114-41-24-77(98)86-25-32-106-36-38-109-39-37-108-35-31-92-51-64(88-90-92)52-110-72-22-17-60(47-65(72)85)18-23-76-87-66-49-63(78-58(6)89-113-59(78)7)19-20-67(66)93(76)28-27-91-29-33-107-34-30-91/h17,19-20,22,43,45,47,49,51,54,56-57,61-62,68-70,73-75,79-80,95-96,102H,11-16,18,21,23-42,44,46,48,50,52H2,1-10H3,(H,86,98)/b53-43-,55-45+/t54-,56+,57+,61-,62+,68-,69+,70-,73+,74-,75-,79+,80+,84+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site.|References:|Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.Products are for research use only. Not for human use.|

Additional information:
Sodium Houttuyfonate is a natural compound extracted from Houttuynia cordata, with anti-inflammatory and anti-fibrotic effects. Sodium Houttuyfonate ameliorates LPS induced mastitis by inhibiting the NF κB pathway.|Product information|CAS Number: 83766-73-8|Molecular Weight: 302.36|Formula: C12H23NaO5S|Chemical Name: sodium 1-hydroxy-3-oxododecane-1-sulfonate|Smiles: [Na+].CCCCCCCCCC(=O)CC(O)S([O-])(=O)=O|InChiKey: HPPWMWCITPGPKK-UHFFFAOYSA-M|InChi: InChI=1S/C12H24O5S.Na/c1-2-3-4-5-6-7-8-9-11(13)10-12(14)18(15,16)17;/h12,14H,2-10H2,1H3,(H,15,16,17);/q;+1/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 5 mg/mL (16.54 mM; ultrasonic and warming and heat to 60°C).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sodium houttuyfonate (25-100 mM) decreases apoptosis of MLE-15 cells induced by CS experiment and inhibits JNK pathway.Toripalimab custom synthesis |In Vivo:|Sodium Houttuyfonate (10-40 mg/kg; p.PMID:33337694 o. for 28 d) reduces lung injury, apoptosis in lung tissues, and the wet/dry (W/D) ratio in ventilator-induced lung injury (VILI) mice. Sodium Houttuyfonate (40 mg/kg; p.o. for 28 d) reduces ROS level and inhibits JNK pathway in VILI mice. Sodium Houttuyfonate (25-100 mg/kg; p.o. once daily for 28 d) ameliorates spatial learning and memory deficiency in Aβ1-42-induced Alzheimer’s disease mice.|References:|Liu Y, et, al. Effect and Mechanism Study of Sodium Houttuyfonate on Ventilator-Induced Lung Injury by Inhibiting ROS and Inflammation. Yonsei Med J. 2021 Jun;62(6):545-554.Liu X, et, al. Sodium houttuyfonate: A review of its antimicrobial, anti-inflammatory and cardiovascular protective effects. Eur J Pharmacol. 2021 Jul 5;902:174110.Zhao Y, et, al. Sodium Houttuyfonate Ameliorates β-amyloid 1-42-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer’s Disease. Mediators Inflamm. 2021 May 31;2021:8817698.Ma K, et, al. Sodium houttuyfonate attenuates dextran sulfate sodium associated colitis precolonized with Candida albicans through inducing β-glucan exposure. J Leukoc Biol. 2021 Mar 8.Products are for research use only. Not for human use.|

Additional information:
Ibrutinib, also known as PCI-32765, is a potent and orally active BTK inhibitor. Ibrutinib binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK. Ibrutinib was approved by the US FDA on November 13, 2013 for the treatment of mantle cell lymphoma.|Product information|CAS Number: 936563-87-0|Molecular Weight: 440.50|Formula: C25H24N6O2|Synonym:|Ibrutinib Racemate|PCI32765 Racemate|PCI 32765 Racemate|Chemical Name: 1-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-ylprop-2-en-1-one|Smiles: C=CC(=O)N1CC(CCC1)N1N=C(C2=C(N)N=CN=C12)C1C=CC(=CC=1)OC1C=CC=CC=1|InChiKey: XYFPWWZEPKGCCK-UHFFFAOYSA-N|InChi: InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Rotenone site |Shelf Life: ≥12 months if stored properly.Apolipoprotein A-I Protein, Human custom synthesis |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32310458 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|PCI-32765 Racemate is oral effective in vivo. It induces lymphocytosis during the first weeks of therapy in patients with CLL. It is also efficacious in autoimmune disease. In the MRL-Fas lupus model, PCI-32765 inhibits collagen-induced arthritis as well as autoantibody production and development of kidney disease. It also diminished FcγRIII-induced production of pro-inflammatory cytokines.|References:|Burger JA, Buggy JJ. Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765). Leuk Lymphoma. 2013 Nov;54(11):2385-91.Products are for research use only. Not for human use.|

Additional information:
Tobramycin is a broad-spectrum antibiotic.|Product information|CAS Number: 32986-56-4|Molecular Weight: 467.51|Formula: C18H37N5O9|Synonym:|Nebramycin Factor 6|Deoxykanamycin B|Chemical Name: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol|Smiles: NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](N)C[C@@H]1O|InChiKey: NLVFBUXFDBBNBW-PBSUHMDJSA-N|InChi: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Calcein Technical Information |Shelf Life: ≥12 months if stored properly.PMID:32567410 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5.|Product information|CAS Number: 76060-35-0|Molecular Weight: 290.35|Formula: C17H22O4|Chemical Name: (1E)-1-(4-hydroxy-3-methoxyphenyl)dec-1-ene-3, 5-dione|Smiles: CCCCCC(=O)CC(=O)/C=C/C1=CC(OC)=C(O)C=C1|InChiKey: JUKHKHMSQCQHEN-VQHVLOKHSA-N|InChi: InChI=1S/C17H22O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h7-11,20H,3-6,12H2,1-2H3/b9-7+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pindolol Purity & Documentation |Shelf Life: ≥12 months if stored properly.PMID:33211278 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|6-Dehydrogingerdione could trigger apoptotic cell death via both mitochondrial- and Fas receptor-mediated pathways. 6-Dehydrogingerdione (6-DG) up-regulates Ser-15 phosphorylation and evoked p53 nuclear translocation. 6-Dehydrogingerdione (6-DG) induces mitochondrial apoptotic pathway.|References:|Chung-Yi Chen, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010 May 12;58(9):5604-11.Products are for research use only. Not for human use.|

Additional information:
Abexinostat, also known as PCI-24781 or CRA-024781, is novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis.Flunarizine custom synthesis |Product information|CAS Number: 58-33-3|Molecular Weight: 320.PMID:31994151 88|Formula: C17H21ClN2S|Synonym:|Diprazin|Romergan|Lergigan|Phenergan|Fellozine|NSC-231688|Chemical Name: dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine hydrochloride|Smiles: Cl.CN(C)C(C)CN1C2=CC=CC=C2SC2=CC=CC=C12|InChiKey: XXPDBLUZJRXNNZ-UHFFFAOYSA-N|InChi: InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Pyridoclax, also known as MR29072, is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells.Nelfinavir supplier Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy.Isocarboxazid medchemexpress Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic.|Product information|CAS Number: 1651890-44-6|Molecular Weight: 426.51|Formula: C29H22N4|Synonym:|MR-29072|Chemical Name: 3-methyl-5-5-[(E)-2-phenylethenyl]-[3,3′-bipyridin]-6-yl-2,3′-bipyridine|Smiles: CC1=CC(=CN=C1C1=CN=CC=C1)C1=NC=C(C=C1/C=C/C1C=CC=CC=1)C1=CN=CC=C1|InChiKey: WGGSYXQFYRWBEC-VAWYXSNFSA-N|InChi: InChI=1S/C29H22N4/c1-21-15-27(20-32-28(21)25-10-6-14-31-18-25)29-23(12-11-22-7-3-2-4-8-22)16-26(19-33-29)24-9-5-13-30-17-24/h2-20H,1H3/b12-11+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32272822 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Gloaguen C, Voisin-Chiret AS, Sopkova-de Oliveira Santos J, Fogha J, Gautier F, De Giorgi M, Burzicki G, Perato S, Pétigny-Lechartier C, Simonin-Le Jeune K, Brotin E, Goux D, N’Diaye M, Lambert B, Louis MH, Ligat L, Lopez F, Juin P, Bureau R, Rault S, Poulain L. First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies. J Med Chem. 2015 Feb 26;58(4):1644-68.Products are for research use only. Not for human use.|

Additional information:
Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development.|Product information|CAS Number: 153088-73-4|Molecular Weight: 454.26|Formula: C20H17Cl2NO7|Chemical Name: (3S)-3-[(benzyloxy)carbonyl]amino-5-(2, 6-dichlorobenzoyloxy)-4-oxopentanoic acid|Smiles: OC(=O)C[C@H](NC(=O)OCC1C=CC=CC=1)C(=O)COC(=O)C1C(Cl)=CC=CC=1Cl|InChiKey: FKJMFCOMZYPWCO-HNNXBMFYSA-N|InChi: InChI=1S/C20H17Cl2NO7/c21-13-7-4-8-14(22)18(13)19(27)29-11-16(24)15(9-17(25)26)23-20(28)30-10-12-5-2-1-3-6-12/h1-8,15H,9-11H2,(H,23,28)(H,25,26)/t15-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Larotrectinib custom synthesis |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Z-Asp-CH2-DCB (10-100 μM) blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng; 16 hours) PBMC in a dose-dependent manner. The production of the chemokines MCP-1, MIP-1α, and MIP-1β was also suppresses.PMID:33250003 The inhibitory effect of Z-Asp-CH2-DCB on TSST-1-activated PBMC is similar, reducing IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively, of levels in untreated cells. Z-Asp-CH2-DCB (10-100 μM; 48 hours) inhibits T-cell proliferation in PBMC stimulated with 200 ng of SEB/ml.|In Vivo:|Z-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks) prevents SU5416-induced septal cell apoptosis.|References:|Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4.Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9.Twumasi P, et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162.Products are for research use only. Not for human use.|

Additional information:
PI-273 is a first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM. PI-273 can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.|Product information|CAS Number: 925069-34-7|Molecular Weight: 381.90|Formula: C16H16ClN3O2S2|Chemical Name: 2-({[(4-chlorophenyl)formamido]methanethioyl}amino)-4-ethyl-5-methylthiophene-3-carboxamide|Smiles: CC1SC(NC(=S)NC(=O)C2C=CC(Cl)=CC=2)=C(C=1CC)C(N)=O|InChiKey: MIERMBQDBLFAFW-UHFFFAOYSA-N|InChi: InChI=1S/C16H16ClN3O2S2/c1-3-11-8(2)24-15(12(11)13(18)21)20-16(23)19-14(22)9-4-6-10(17)7-5-9/h4-7H,3H2,1-2H3,(H2,18,21)(H2,19,20,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 6.PMID:32538180 02 mg/mL (15.76 mM; ultrasonic and warming and heat to 60°C)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PI-273 (2 μM; 48 hours) blocks the cell cycle at the G2-M phase. PI-273 (2 μM; 48 hours) induces cell apoptosis in all three Ras wild-type breast cancer cells: MCF-7, T-47D, and SK-BR-3. PI-273 (0.5-2 μM; for 3 days) can suppress the AKT signaling pathway in a dose- and time-dependent manner. PI-273 of 1 μM and 2 μM inhibits the cell proliferation of both MCF-7 and T-47D cells in a time-dependent manner.|In Vivo:|PI-273 (intraperitoneal injection; 25 mg/kg/day; 15 days) profoundly suppresses the tumor volume and weight in the MCF-7 xenografts. PI-273 (0.5 mg/kg (intravenously) or 1.5 mg/kg (intragastrically); 0.08-5 hours) has a half-life of 0.411 hours for intravenous administration and 1.321 hours for intragastrical administration, and the absolute bioavailability of PI-273 is 5.1%.|References:|Li J, et al. PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells. Cancer Res. 2017 Nov 15;77(22):6253-6266.Products are for research use only. Not for human use.|

Additional information:
Oxysophoridine (Sophoridine N-oxide) is a bioactive alkaloid extracted from the Sophora alopecuroides Linn. Oxysophoridine (Sophoridine N-oxide) shows anti inflammatory, anti oxidative stress and anti apoptosis effects.|Product information|CAS Number: 54809-74-4|Molecular Weight: 264.36|Formula: C15H24N2O2|Chemical Name: (1R,2R,9R,17S)-6-oxo-7,13-diazatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadecan-13-ium-13-olate|Smiles: [O-][N+]12CCC[C@@H]3CN4[C@H](CCCC4=O)[C@@H](CCC1)[C@@H]23|InChiKey: XVPBINOPNYFXID-ACTGZQEFSA-N|InChi: InChI=1S/C15H24N2O2/c18-14-7-1-6-13-12-5-3-9-17(19)8-2-4-11(15(12)17)10-16(13)14/h11-13,15H,1-10H2/t11-,12-,13-,15+,17?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (126.08 mM; Need ultrasonic). H2O : 125 mg/mL (472.84 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 1794937-18-0|Molecular Weight: 278.71|Formula: C13H10ClN3O2|Chemical Name: 2-{[6-chloro-3-(²H₃)methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]methyl}benzonitrile|Smiles: [2H]C([2H])([2H])N1C(=O)N(CC2=CC=CC=C2C#N)C(Cl)=CC1=O|InChiKey: BVUJISIVAHYNLI-FIBGUPNXSA-N|InChi: InChI=1S/C13H10ClN3O2/c1-16-12(18)6-11(14)17(13(16)19)8-10-5-3-2-4-9(10)7-15/h2-6H,8H2,1H3/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent an antineoplastic agent.|Product information|CAS Number: 71861-76-2|Molecular Weight: 290.25|Formula: C14H11FN2O4|Chemical Name: 1-acetyl-5-fluoro-3-(2-methylbenzoyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione|Smiles: CC(=O)N1C=C(F)C(=O)N(C(=O)C2=CC=CC=C2C)C1=O|InChiKey: DRXHAKVGNKHFMB-UHFFFAOYSA-N|InChi: InChI=1S/C14H11FN2O4/c1-8-5-3-4-6-10(8)12(19)17-13(20)11(15)7-16(9(2)18)14(17)21/h3-7H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{D-Cycloserine} site|{D-Cycloserine} Anti-infection|{D-Cycloserine} Protocol|{D-Cycloserine} In stock|{D-Cycloserine} manufacturer|{D-Cycloserine} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Mirin} MedChemExpress|{Mirin} PI3K/Akt/mTOR|{Mirin} Purity & Documentation|{Mirin} In Vitro|{Mirin} supplier|{Mirin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31985186 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d).|Products are for research use only. Not for human use.|

Additional information:
Viquidil hydrochloride (Quinotoxine hydrochloride), an isomer of Quinidine, is a cerebral vasodilator agent. Viquidil hydrochloride shows antithrombotic activity.|Product information|CAS Number: 52211-63-9|Molecular Weight: 360.88|Formula: C20H25ClN2O2|Chemical Name: 3-[(3R,4R)-3-ethenylpiperidin-4-yl]-1-(6-methoxyquinolin-4-yl)propan-1-one hydrochloride|Smiles: Cl.{{Fmoc-L-Trp(Boc)-OH} site|{Fmoc-L-Trp(Boc)-OH} {Amino Acid Derivatives}|{Fmoc-L-Trp(Boc)-OH} Technical Information|{Fmoc-L-Trp(Boc)-OH} Description|{Fmoc-L-Trp(Boc)-OH} supplier|{Fmoc-L-Trp(Boc)-OH} Autophagy} COC1=CC2=C(C=CN=C2C=C1)C(=O)CC[C@@H]1CCNC[C@@H]1C=C|InChiKey: YUBRJAHSRSIPKX-LDXVYITESA-N|InChi: InChI=1S/C20H24N2O2.{{Ferritin heavy chain/FTH1 Protein, Human} web|{Ferritin heavy chain/FTH1 Protein, Human} Biological Activity|{Ferritin heavy chain/FTH1 Protein, Human} References|{Ferritin heavy chain/FTH1 Protein, Human} custom synthesis|{Ferritin heavy chain/FTH1 Protein, Human} Epigenetics} ClH/c1-3-14-13-21-10-8-15(14)4-7-20(23)17-9-11-22-19-6-5-16(24-2)12-18(17)19;/h3,5-6,9,11-12,14-15,21H,1,4,7-8,10,13H2,2H3;1H/t14-,15+;/m0.PMID:32529926 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 15 mg/mL (41.57 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Viquidil hydrochloride (Quinotoxine hydrochloride) increases the cerebral blood flow in the rabbit considerably.|Products are for research use only. Not for human use.|

Additional information:
Nordihydrocapsaicin is a capsaicinoid analog and congener of capsaicin in chili peppers.{{Isradipine} MedChemExpress|{Isradipine} Calcium Channel|{Isradipine} Biological Activity|{Isradipine} In Vivo|{Isradipine} supplier|{Isradipine} Autophagy} |Product information|CAS Number: 28789-35-7|Molecular Weight: 293.40|Formula: C17H27NO3|Chemical Name: N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyloctanamide|Smiles: COC1=CC(CNC(=O)CCCCCC(C)C)=CC=C1O|InChiKey: VQEONGKQWIFHMN-UHFFFAOYSA-N|InChi: InChI=1S/C17H27NO3/c1-13(2)7-5-4-6-8-17(20)18-12-14-9-10-15(19)16(11-14)21-3/h9-11,13,19H,4-8,12H2,1-3H3,(H,18,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Salinomycin} MedChemExpress|{Salinomycin} Wnt|{Salinomycin} NF-κB|{Salinomycin} Technical Information|{Salinomycin} Formula|{Salinomycin} manufacturer} |Shelf Life: ≥12 months if stored properly.PMID:31985940 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.|Product information|CAS Number: 47922-48-5|Molecular Weight: 1154.23|Formula: C54H71N15O14|Chemical Name: (4S)-5-[(2S)-2-[(carbamoylmethyl)carbamoyl]pyrrolidin-1-yl]-4-[(2S)-2-{2-[(2S)-2-[(2S)-3-hydroxy-2-[(2S)-2-[(2S)-3-(1H-imidazol-5-yl)-2-{[(2S)-5-oxopyrrolidin-2-yl]formamido}propanamido]-3-(1H-indol-3-yl)propanamido]propanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-4-methylpentanamido]-5-oxopentanamide|Smiles: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O|InChiKey: WPKQYFUSPONRAT-BXXNOCLASA-N|InChi: InChI=1S/C54H71N15O14/c1-28(2)18-37(49(78)64-36(13-15-43(55)72)54(83)69-17-5-8-42(69)53(82)59-24-44(56)73)63-46(75)25-60-47(76)38(19-29-9-11-32(71)12-10-29)65-52(81)41(26-70)68-50(79)39(20-30-22-58-34-7-4-3-6-33(30)34)66-51(80)40(21-31-23-57-27-61-31)67-48(77)35-14-16-45(74)62-35/h3-4,6-7,9-12,22-23,27-28,35-42,58,70-71H,5,8,13-21,24-26H2,1-2H3,(H2,55,72)(H2,56,73)(H,57,61)(H,59,82)(H,60,76)(H,62,74)(H,63,75)(H,64,78)(H,65,81)(H,66,80)(H,67,77)(H,68,79)/t35-,36-,37-,38-,39-,40-,41-,42-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity.|Product information|CAS Number: 100940-65-6|Molecular Weight: 1221.{{SMARCA2/4-IN-2} MedChemExpress|{SMARCA2/4-IN-2} PROTAC|{SMARCA2/4-IN-2} Activator|{SMARCA2/4-IN-2} Protocol|{SMARCA2/4-IN-2} Formula|{SMARCA2/4-IN-2} supplier} 32|Formula: C60H76N12O16|Chemical Name: 3-hydroxy-N-[(3R, 7S, 16S, 23R, 27S, 36S)-23-(3-hydroxyquinoline-2-amido)-8, 11, 28, 31-tetramethyl-2, 6, 9, 12, 15, 22, 26, 29, 32, 35-decaoxo-7, 27-bis(propan-2-yl)-5, 25-dioxa-1, 8, 11, 14, 21, 28, 31, 34-octaazatricyclo[34.4.0.0, ]tetracontan-3-yl]quinoline-2-carboxamide|Smiles: CN1CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)OC[C@@H](NC(=O)C2=NC3=CC=CC=C3C=C2O)C(=O)N2CCCC[C@H]2C(=O)NCC1=O|InChiKey: WXIVYIYCEBUEHL-RTQGILJWSA-N|InChi: InChI=1S/C60H76N12O16/c1-33(2)51-59(85)87-31-39(65-55(81)49-43(73)25-35-17-9-11-19-37(35)63-49)57(83)71-23-15-13-21-41(71)53(79)62-28-46(76)68(6)30-48(78)70(8)52(34(3)4)60(86)88-32-40(66-56(82)50-44(74)26-36-18-10-12-20-38(36)64-50)58(84)72-24-16-14-22-42(72)54(80)61-27-45(75)67(5)29-47(77)69(51)7/h9-12,17-20,25-26,33-34,39-42,51-52,73-74H,13-16,21-24,27-32H2,1-8H3,(H,61,80)(H,62,79)(H,65,81)(H,66,82)/t39-,40-,41+,42+,51+,52+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Opipramol} MedChemExpress|{Opipramol} Sigma Receptor|{Opipramol} Biological Activity|{Opipramol} In Vivo|{Opipramol} supplier|{Opipramol} Epigenetics} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sandramycin has antimicrobial activity wtih MIC values of 0.PMID:32329329 024 μg/mL, 0.012 μg/mL, 0.012 μg/mL, 0.098 μg/mL, 0.024 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Bacillus subtilis (Rec+) A22508-2, B. subtilis (Rec-) A22509-2-2, Staphylocccus aureus 209P-A9497, S. aureus (echinomycin-resistant) A9628, Streptococcus faecalis A96 1 1, Escherichia coli A151 19 and E. coli (actinomycin-sensitive) A21780 (AS-19), respectively. Sandramycin inhibits cancer cells growth of L1210, B16, HCT118, RPMI8226, A431, RKO, SU-DHL6 and SU-DHL10 cells with IC50 values of 0.02 nM, 0.07 nM, 0.8 nM, 3.8 nM, 3.1 nM, 1.3 nM, 5.9 nM and 3.3 nM, respectively.|In Vivo:|Sandramycin (0.0125-1.6 mg/kg; intraperitoneal injection; daily; for 5 days; CDF1 female mice) treatment shows moderately active in vivo against leukemia P388 in mice.|References:|J A Matson, et al. Sandramycin, a Novel Antitumor Antibiotic Produced by a Nocardioides Sp. Production, Isolation, Characterization and Biological Properties. J Antibiot (Tokyo). 1989 Dec;42(12):1763-7.Katsushi Katayama, et al. Total Synthesis of Sandramycin and Its Analogues via a Multicomponent Assemblage. Org Lett. 2014 Jan 17;16(2):428-31.Products are for research use only. Not for human use.|

Additional information:
Tyclopyrazoflor is an anthranilamide compound with pesticidal activity.|Product information|CAS Number: 1477919-27-9|Molecular Weight: 406.85|Formula: C16H18ClF3N4OS|Chemical Name: N-[3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl]-N-ethyl-3-[(3,3,3-trifluoropropyl)sulfanyl]propanamide|Smiles: CCN(C(=O)CCSCCC(F)(F)F)C1=CN(N=C1Cl)C1=CN=CC=C1|InChiKey: DBHVHTPMRCXCIY-UHFFFAOYSA-N|InChi: InChI=1S/C16H18ClF3N4OS/c1-2-23(14(25)5-8-26-9-6-16(18,19)20)13-11-24(22-15(13)17)12-4-3-7-21-10-12/h3-4,7,10-11H,2,5-6,8-9H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
DM3 (Maytansinoid DM3) is a maytansine analog bearing disulfide or thiol groups and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs).|Product information|CAS Number: 796073-54-6|Molecular Weight: 766.{{Ofatumumab} site|{Ofatumumab} Immunology/Inflammation|{Ofatumumab} Technical Information|{Ofatumumab} In Vivo|{Ofatumumab} custom synthesis|{Ofatumumab} Epigenetic Reader Domain} 34|Formula: C37H52ClN3O10S|Synonym:|Maytansinoid DM3|Chemical Name: (1S, 2R, 3S, 5S, 6S, 20R, 21S)-11-chloro-21-hydroxy-12, 20-dimethoxy-2, 5, 9, 16-tetramethyl-8, 23-dioxo-4, 24-dioxa-9, 22-diazatetracyclo[19.{{Afatinib dimaleate} site|{Afatinib dimaleate} MAPK/ERK Pathway|{Afatinib dimaleate} NF-κB|{Afatinib dimaleate} Biological Activity|{Afatinib dimaleate} Data Sheet|{Afatinib dimaleate} manufacturer} 3.1.1, .0, ]hexacosa-10, 12, 14(26), 16, 18-pentaen-6-yl (2S)-2-(N-methyl-4-sulfanylpentanamido)propanoate|Smiles: C[C@@]12O[C@H]1[C@H](C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(OC)C(Cl)=C(C=1)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(=O)CCC(C)S)OC |c:19,t:17||InChiKey: LJFFDOBFKICLHN-SVMDFPMXSA-N|InChi: InChI=1S/C37H52ClN3O10S/c1-20-11-10-12-28(48-9)37(46)19-27(49-35(45)39-37)22(3)33-36(5,51-33)29(50-34(44)23(4)40(6)30(42)14-13-21(2)52)18-31(43)41(7)25-16-24(15-20)17-26(47-8)32(25)38/h10-12,16-17,21-23,27-29,33,46,52H,13-15,18-19H2,1-9H3,(H,39,45)/b12-10-,20-11-/t21?,22-,23+,27+,28-,29+,33+,36+,37+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32491296 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).Products are for research use only. Not for human use.|

Additional information:
m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 65673-48-5|Molecular Weight: 211.26|Formula: C11H17NO3|Chemical Name: 4-[2-(2-methoxyethoxy)ethoxy]aniline|Smiles: COCCOCCOC1C=CC(N)=CC=1|InChiKey: IWXQVPLYQQTJTR-UHFFFAOYSA-N|InChi: InChI=1S/C11H17NO3/c1-13-6-7-14-8-9-15-11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Retifanlimab} web|{Retifanlimab} Purity & Documentation|{Retifanlimab} In stock|{Retifanlimab} supplier|{Retifanlimab} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Colesevelam} medchemexpress|{Colesevelam} Protocol|{Colesevelam} Formula|{Colesevelam} custom synthesis|{Colesevelam} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33357119 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

Additional information:
Dimethylurea/citric acid is a highly efficient deep eutectic solvent (DES).{{Hydroxyurea} site|{Hydroxyurea} Cell Cycle/DNA Damage|{Hydroxyurea} Purity & Documentation|{Hydroxyurea} In stock|{Hydroxyurea} custom synthesis|{Hydroxyurea} Cancer} Dimethylurea/citric acid can be used as a catalyst and a green reaction medium for the synthesis of bis(indolyl)methanes, quinolines and aryl-4, 5-diphenyl-1H-imidazoles.PMID:32658556 |Product information|CAS Number: 53798-97-3|Molecular Weight: 220.18|Formula: C8H12O7|Chemical Name: 3-hydroxy-5-methoxy-3-(methoxycarbonyl)-5-oxopentanoic acid|Smiles: COC(=O)CC(O)(CC(O)=O)C(=O)OC|InChiKey: OMIHCBSQSYMFDP-UHFFFAOYSA-N|InChi: InChI=1S/C8H12O7/c1-14-6(11)4-8(13,3-5(9)10)7(12)15-2/h13H,3-4H2,1-2H3,(H,9,10)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
PF-02413873 (PF-2413873) is a potent selective, fully competitive and orally active nonsteroidal progesterone receptor (PR) antagonist, with a Ki of 2.6 nM. PF-02413873 can block progesterone binding and PR nuclear translocation, and inhibit endometrial growth in vivo.|Product information|CAS Number: 936345-35-6|Molecular Weight: 359.44|Formula: C18H21N3O3S|Chemical Name: 4-{[3-cyclopropyl-1-(methanesulfonylmethyl)-5-methyl-1H-pyrazol-4-yl]oxy}-2,6-dimethylbenzonitrile|Smiles: CC1C=C(C=C(C)C=1C#N)OC1C(=NN(CS(C)(=O)=O)C=1C)C1CC1|InChiKey: QSFGZNVRVZHUGV-UHFFFAOYSA-N|InChi: InChI=1S/C18H21N3O3S/c1-11-7-15(8-12(2)16(11)9-19)24-18-13(3)21(10-25(4,22)23)20-17(18)14-5-6-14/h7-8,14H,5-6,10H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (278.PMID:32701010 21 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-02413873 shows potent PR antagonist activity with a derived Ki of 9.7 nM in the T47D native functional assay. PF-02413873 (1 nM-10 μM) induces nuclear translocation only at high concentrations (>3 μM).|In Vivo:|PF-02413873 (2.5 and 10 mg/kg; p.o. twice daily for 10 days) induces a statistically significant reduction in endometrial thickness in cynomolgus macaques. PF-02413873 (3 mg/kg; a single p.o.) exhibits t1/2 (4.2 h), Cmax (162 ng/mL) and CL/F (41 mL/min/kg).|Products are for research use only. Not for human use.|

Additional information:
Cyclooctyne-O-PFP ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 886209-60-5|Molecular Weight: 348.26|Formula: C16H13F5O3|Chemical Name: 2,3,4,5,6-pentafluorophenyl 2-(cyclooct-2-yn-1-yloxy)acetate|Smiles: O=C(COC1CCCCCC#C1)OC1C(F)=C(F)C(F)=C(F)C=1F|InChiKey: FTKRNGMQMZGSDF-UHFFFAOYSA-N|InChi: InChI=1S/C16H13F5O3/c17-11-12(18)14(20)16(15(21)13(11)19)24-10(22)8-23-9-6-4-2-1-3-5-7-9/h9H,1-4,6,8H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (287.14 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|Products are for research use only. Not for human use.|

Additional information:
Agaric acid (Agaricinic Acid) is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Agaric acid promotes efflux of accumulated Ca2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid is used to regulate lipid metabolism.|Product information|CAS Number: 666-99-9|Molecular Weight: 416.55|Formula: C22H40O7|Chemical Name: 1-hexadecyl-2-hydroxypropane-1,2,3-tricarboxylic acid|Smiles: CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(CC(O)=O)C(O)=O|InChiKey: HZLCGUXUOFWCCN-UHFFFAOYSA-N|InChi: InChI=1S/C22H40O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18(20(25)26)22(29,21(27)28)17-19(23)24/h18,29H,2-17H2,1H3,(H,23,24)(H,25,26)(H,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tenofovir Disoproxil} site|{Tenofovir Disoproxil} HIV|{Tenofovir Disoproxil} Protocol|{Tenofovir Disoproxil} References|{Tenofovir Disoproxil} manufacturer|{Tenofovir Disoproxil} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Penfluridol} MedChemExpress|{Penfluridol} Autophagy|{Penfluridol} Activator|{Penfluridol} Technical Information|{Penfluridol} Description|{Penfluridol} manufacturer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32565113 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Antifungal agent 6 is an antifungal agent.|Product information|CAS Number: 332849-40-8|Molecular Weight: 369.41|Formula: C21H23NO5|Chemical Name: 3-{[2-(2H-1,3-benzodioxol-5-yl)ethyl]carbamoyl}-2-[(4-methylphenyl)methyl]propanoic acid|Smiles: CC1C=CC(CC(CC(=O)NCCC2C=C3OCOC3=CC=2)C(O)=O)=CC=1|InChiKey: WFDVRQOVLBEPIS-UHFFFAOYSA-N|InChi: InChI=1S/C21H23NO5/c1-14-2-4-15(5-3-14)10-17(21(24)25)12-20(23)22-9-8-16-6-7-18-19(11-16)27-13-26-18/h2-7,11,17H,8-10,12-13H2,1H3,(H,22,23)(H,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nateglinide} MedChemExpress|{Nateglinide} Membrane Transporter/Ion Channel|{Nateglinide} Purity & Documentation|{Nateglinide} Description|{Nateglinide} supplier|{Nateglinide} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Abiraterone} medchemexpress|{Abiraterone} Metabolic Enzyme/Protease|{Abiraterone} Protocol|{Abiraterone} Description|{Abiraterone} custom synthesis|{Abiraterone} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32800584 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 1331888-08-4|Molecular Weight: 208.{{Fexinidazole} MedChemExpress|{Fexinidazole} Parasite|{Fexinidazole} Protocol|{Fexinidazole} In Vivo|{Fexinidazole} custom synthesis|{Fexinidazole} Epigenetic Reader Domain} 29|Formula: C8H18N4O2|Chemical Name: (2S)-2-amino-5-[N’,N”-di(²H₃)methylcarbamimidamido]pentanoic acid|Smiles: [2H]C([2H])([2H])N=C(NCCC[C@H](N)C(O)=O)NC([2H])([2H])[2H]|InChiKey: HVPFXCBJHIIJGS-BGUMHVNPSA-N|InChi: InChI=1S/C8H18N4O2/c1-10-8(11-2)12-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H,13,14)(H2,10,11,12)/t6-/m0/s1/i1D3,2D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32420651 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 1794782-57-2|Molecular Weight: 377.96|Formula: C17H26ClN3O2S|Chemical Name: di(²H₃)methyl(2-{5-[(pyrrolidine-1-sulfonyl)methyl]-1H-indol-3-yl}ethyl)amine hydrochloride|Smiles: Cl.[2H]C([2H])([2H])N(CCC1=CNC2=CC=C(CS(=O)(=O)N3CCCC3)C=C12)C([2H])([2H])[2H]|InChiKey: FUORSACTMVYHCT-TXHXQZCNSA-N|InChi: InChI=1S/C17H25N3O2S.PMID:31644112 ClH/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20;/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3;1H/i1D3,2D3;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 1329610-75-4|Molecular Weight: 300.28|Formula: C13H13F2N3O3|Chemical Name: (2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-(²H₃)methyl-4-(1H-1,2,4-triazol-1-yl)butanoic acid|Smiles: [2H]C([2H])([2H])[C@@H](C(O)=O)[C@](O)(CN1C=NC=N1)C1=CC=C(F)C=C1F|InChiKey: QUOMTGYGYQRSMC-JSFBOPGTSA-N|InChi: InChI=1S/C13H13F2N3O3/c1-8(12(19)20)13(21,5-18-7-16-6-17-18)10-3-2-9(14)4-11(10)15/h2-4,6-8,21H,5H2,1H3,(H,19,20)/t8-,13+/m0/s1/i1D3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tivozanib} web|{Tivozanib} Protein Tyrosine Kinase/RTK|{Tivozanib} Purity & Documentation|{Tivozanib} Formula|{Tivozanib} custom synthesis|{Tivozanib} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{IL-4 Protein, Human} site|{IL-4 Protein, Human} Technical Information|{IL-4 Protein, Human} Description|{IL-4 Protein, Human} manufacturer|{IL-4 Protein, Human} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32512975 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs.|Product information|CAS Number: 674786-20-0|Molecular Weight: 424.49|Formula: C25H28O6|Chemical Name: 1-(3,7-dihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)-2-(5-methoxy-2,2-dimethyl-2H-chromen-6-yl)ethan-1-one|Smiles: COC1=C2C=CC(C)(C)OC2=CC=C1CC(=O)C1=CC2CC(O)C(C)(C)OC=2C=C1O|InChiKey: RMVZECFNOTWEKD-UHFFFAOYSA-N|InChi: InChI=1S/C25H28O6/c1-24(2)9-8-16-20(30-24)7-6-14(23(16)29-5)11-18(26)17-10-15-12-22(28)25(3,4)31-21(15)13-19(17)27/h6-10,13,22,27-28H,11-12H2,1-5H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (588.{{X-GAL} web|{X-GAL} Glucosidase|{X-GAL} Protocol|{X-GAL} Formula|{X-GAL} supplier|{X-GAL} Epigenetic Reader Domain} 94 mM; Need ultrasonic).{{Fura-2 AM} medchemexpress|{Fura-2 AM} {Fluorescent Dye}|{Fura-2 AM} Protocol|{Fura-2 AM} Data Sheet|{Fura-2 AM} manufacturer|{Fura-2 AM} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32608267 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Assays are initiated by the addition of [35S]GTPγS, and the rates of aGPCR-stimulated G protein activation ([35S]GTPγS binding to Gα) are measured with or without the influence of added compounds. Dihydromunduletone (DHM) inhibits the kinetics of GPR56 7TM-stimulated G13 GTPγS binding to varying degrees. Dihydromunduletone is the best inhibitory compound and reduced the rate at which GPR56 7TM activated G13 >75% (from 0.18 to 0.04 minute−1). At a concentration of Dihydromunduletone (DHM) that maximally inhibits GPR56 (50 μM), the rate of GPR114 7TM-stimulated Gs activity is also inhibited dramatically. When Dihydromunduletone (50 μM) is applied to the GPR110 7TM, it fails to inhibit GPR110 stimulation of Gq GTPγS binding. Cells transfected with GPR56 A386M 7TM are incubated with increasing concentrations of Dihydromunduletone. P7 peptide agonist is added, and SRE-luciferase activity is measured. Dihydromunduletone inhibits the P7 peptide-induced luciferase activity in a concentration-dependent manner. Cells are also treated with a fixed concentration of 3 µM Dihydromunduletone and then stimulated with an increasing concentration of P7 peptide agonist. Dihydromunduletone treatment blunts P7 peptide activation at each concentration. In conclusion, Dihydromunduletone antagonizes synthetic-peptide agonist and tethered-peptide agonist-mediated aGPCR activation in isolated membranes and HEK293T cell-based assays, but it does not inhibit basal receptor signaling.|Products are for research use only. Not for human use.|

Additional information:
Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis.|Product information|CAS Number: 205304-88-7|Molecular Weight: 816.02|Formula: C41H61N5O10S|Chemical Name: (2S,4R)-4-({2-[(1R,3R)-1-(acetyloxy)-4-methyl-3-[(2S,3S)-3-methyl-2-{[(2R)-1-methylpiperidin-2-yl]formamido}-N-[(propanoyloxy)methyl]pentanamido]pentyl]-1,3-thiazol-4-yl}formamido)-5-(4-hydroxyphenyl)-2-methylpentanoic acid|Smiles: CN1CCCC[C@@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N(COC(=O)CC)[C@H](C[C@@H](OC(C)=O)C1=NC(=CS1)C(=O)N[C@@H](CC1C=CC(O)=CC=1)C[C@H](C)C(O)=O)C(C)C|InChiKey: NZCNGJHOIKMMCG-UZRVFEFTSA-N|InChi: InChI=1S/C41H61N5O10S/c1-9-25(5)36(44-38(51)32-13-11-12-18-45(32)8)40(52)46(23-55-35(49)10-2)33(24(3)4)21-34(56-27(7)47)39-43-31(22-57-39)37(50)42-29(19-26(6)41(53)54)20-28-14-16-30(48)17-15-28/h14-17,22,24-26,29,32-34,36,48H,9-13,18-21,23H2,1-8H3,(H,42,50)(H,44,51)(H,53,54)/t25-,26-,29+,32+,33+,34+,36-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro.|Product information|CAS Number: 2146088-12-0|Molecular Weight: 1271.44|Formula: C60H102O28|Chemical Name: (2R,3S,4R,5R,6S)-2-({[(2S,3S,4S,5R,6R)-6-{[(3S,6S)-6-[(3aR,7R,9bS,11aS)-3a,6,6,9b,11a-pentamethyl-7-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-hydroxy-2-methylheptan-3-yl]oxy}-3,4-dihydroxy-5-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}methyl)-6-(hydroxymethyl)oxane-3,4,5-triol|Smiles: C[C@@H](CC[C@H](O[C@@H]1O[C@H](OC[C@H]2O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]2O)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C(C)(C)O)C1CC[C@]2(C)C3CC=C4C(CC[C@@H](O[C@@H]5O[C@H](CO[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)[C@@H](O)[C@H](O)[C@H]5O)C4(C)C)[C@@]3(C)CC[C@]21C|InChiKey: GZWOEHKZNJLOLI-YKFKSEOQSA-N|InChi: InChI=1S/C60H102O28/c1-24(9-13-35(57(4,5)78)86-55-50(87-54-48(76)43(71)38(66)30(21-63)83-54)45(73)49(77)52(88-55)80-22-31-39(67)41(69)36(64)28(19-61)81-31)25-15-16-60(8)33-12-10-26-27(58(33,6)17-18-59(25,60)7)11-14-34(56(26,2)3)85-53-47(75)44(72)40(68)32(84-53)23-79-51-46(74)42(70)37(65)29(20-62)82-51/h10,24-25,27-55,61-78H,9,11-23H2,1-8H3/t24-,25?,27?,28-,29+,30+,31+,32+,33?,34+,35-,36-,37+,38+,39+,40+,41+,42-,43-,44-,45-,46+,47+,48+,49-,50+,51+,52-,53-,54-,55+,58+,59-,60+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Isavuconazole} web|{Isavuconazole} Antibiotic|{Isavuconazole} Technical Information|{Isavuconazole} In Vivo|{Isavuconazole} manufacturer|{Isavuconazole} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{(E/Z)-4-Hydroxytamoxifen} MedChemExpress|{(E/Z)-4-Hydroxytamoxifen} Metabolic Enzyme/Protease|{(E/Z)-4-Hydroxytamoxifen} Activator|{(E/Z)-4-Hydroxytamoxifen} Biological Activity|{(E/Z)-4-Hydroxytamoxifen} In stock|{(E/Z)-4-Hydroxytamoxifen} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32116157 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
6-Benzylaminopurine is a first-generation synthetic cytokinin that elicits plant growth and development, also is an inhibitor of respiratory kinase in plants, increases post-harvest life of green vegetables.|Product information|CAS Number: 1214-39-7|Molecular Weight: 225.25|Formula: C12H11N5|Chemical Name: N-benzyl-7H-purin-6-amine|Smiles: C(NC1=NC=NC2N=CNC=21)C1C=CC=CC=1|InChiKey: NWBJYWHLCVSVIJ-UHFFFAOYSA-N|InChi: InChI=1S/C12H11N5/c1-2-4-9(5-3-1)6-13-11-10-12(15-7-14-10)17-8-16-11/h1-5,7-8H,6H2,(H2,13,14,15,16,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (221.{{Tuvusertib} medchemexpress|{Tuvusertib} PI3K/Akt/mTOR|{Tuvusertib} NF-κB|{Tuvusertib} Technical Information|{Tuvusertib} In stock|{Tuvusertib} custom synthesis} 98 mM; Need ultrasonic).PMID:31830807 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Setrobuvir (ANA598) is an orally active non-nucleosidic HCV NS5B polymerase inhibitor. ANA-598 inhibits both de novo RNA synthesis and primer extension, with IC50s between 4 and 5 nM. Setrobuvir also shows excellent binding affinity to SARS-CoV-2 RdRp and induces RdRp inhibition.|Product information|CAS Number: 1071517-39-9|Molecular Weight: 560.62|Formula: C25H25FN4O6S2|Chemical Name: N-{3-[(1R,2S,7R,8S)-3-[(4-fluorophenyl)methyl]-6-hydroxy-4-oxo-3-azatricyclo[6.2.1.0²,⁷]undec-5-en-5-yl]-1,1-dioxo-4H-1λ⁶,2,4-benzothiadiazin-7-yl}methanesulfonamide|Smiles: CS(=O)(=O)NC1=CC2=C(C=C1)NC(=NS2(=O)=O)C1=C(O)[C@H]2[C@H]([C@H]3C[C@@H]2CC3)N(CC2C=CC(F)=CC=2)C1=O|InChiKey: DEKOYVOWOVJMPM-RLHIPHHXSA-N|InChi: InChI=1S/C25H25FN4O6S2/c1-37(33,34)28-17-8-9-18-19(11-17)38(35,36)29-24(27-18)21-23(31)20-14-4-5-15(10-14)22(20)30(25(21)32)12-13-2-6-16(26)7-3-13/h2-3,6-9,11,14-15,20,22,28,31H,4-5,10,12H2,1H3,(H,27,29)/t14-,15+,20+,22-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tafasitamab} site|{Tafasitamab} Apoptosis|{Tafasitamab} Technical Information|{Tafasitamab} Formula|{Tafasitamab} manufacturer|{Tafasitamab} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:33314897 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Setrobuvir (ANA598) is a non-nucleoside inhibitor that binds to the palm pocket of the HCV polymerase and has an EC50 against HCV genotype 1b/Con1-containing subgenomic replicons in the nanomolar range. Setrobuvir appears to inhibit both de novoinitiated RNA synthesis and primer extension, and its activity is unchanged by the presence of mutations that modify the activity of thumb-binding non-nucleoside inhibitors.|Products are for research use only. Not for human use.|

Additional information:
Propargyl-PEG3-methyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.|Product information|CAS Number: 2086689-09-8|Molecular Weight: 230.26|Formula: C11H18O5|Chemical Name: methyl 3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanoate|Smiles: COC(=O)CCOCCOCCOCC#C|InChiKey: SDSYWBQIDUXXIQ-UHFFFAOYSA-N|InChi: InChI=1S/C11H18O5/c1-3-5-14-7-9-16-10-8-15-6-4-11(12)13-2/h1H,4-10H2,2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Balovaptan} medchemexpress|{Balovaptan} GPCR/G Protein|{Balovaptan} Technical Information|{Balovaptan} Data Sheet|{Balovaptan} custom synthesis|{Balovaptan} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:26446225 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|Products are for research use only. Not for human use.|

Additional information:
Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin.|Product information|CAS Number: 82189-04-6|Molecular Weight: 638.79|Formula: C36H50N2O8|Chemical Name: 15,22,24-trihydroxy-5-methoxy-14,16-dimethyl-3-oxo-2-azabicyclo[18.3.1]tetracosa-1(24),6,8,10,16,20,22-heptaen-13-yl 2-(cyclohexylformamido)propanoate|Smiles: CC1=CCCC2=CC(O)=CC(NC(=O)CC(C=CC=CC=CCC(OC(=O)C(C)NC(=O)C3CCCCC3)C(C)C1O)OC)=C2O|InChiKey: VVJDHJZQBGWPEQ-QFUIHVKNSA-N|InChi: InChI=1S/C36H50N2O8/c1-23-14-13-17-27-20-28(39)21-30(34(27)42)38-32(40)22-29(45-4)18-11-6-5-7-12-19-31(24(2)33(23)41)46-36(44)25(3)37-35(43)26-15-9-8-10-16-26/h5-7,11-12,14,18,20-21,24-26,29,31,33,39,41-42H,8-10,13,15-17,19,22H2,1-4H3,(H,37,43)(H,38,40)/b6-5-,12-7-,18-11-,23-14-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Aldosterone} medchemexpress|{Aldosterone} Endogenous Metabolite|{Aldosterone} Purity & Documentation|{Aldosterone} Description|{Aldosterone} manufacturer|{Aldosterone} Epigenetic Reader Domain} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ansatrienin B exhibits antimicrobial activities of Penicillium chrysogenuin 1AM 7106, Mucor pusillus IAM 6122, Rhizopus delemar IAM 6015, Saccharornyces cerevisiae IFO 0304, Candida utilus IFO 0396 and Candida krusei IFO 0590 with MIC values of 12.{{Tropicamide} medchemexpress|{Tropicamide} mAChR|{Tropicamide} Technical Information|{Tropicamide} References|{Tropicamide} custom synthesis|{Tropicamide} Epigenetic Reader Domain} 5 μg/ml, 12.PMID:27217159 5 μg/ml, 12.5 μg/ml, 8.0 μg/ml, 4.0 μg/ml, 4.0 μg/ml, and 4.0 μg/ml, respectively. Ansatrienin B inhibits the release of 45calcium into the culture medium by fetal rat long bones with an apparent halfmaximal inhibition (IC50) value of 21 nM. Ansatrienin B inhibits the translationof the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50=58 nM) in A549 cells). At the same time, it also inhibits TNF-α-induced expression of ICAM-1 with an IC50 of 300 nM.|In Vivo:|Ansatrienin B (intraperitoneal injection; once daily; 6 days) is against P-388 -injected mouse tumor growth. The LD50 value in mice of MTN-II is 80 mg/kg in CDF1 male mice.|Products are for research use only. Not for human use.|

Additional information:
Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells in combination with TLR8 agonist CL 075. Transfection into NIT-1 β cells induces β-cell apoptosis. Immunostimulant. Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune responses against a peptide-based vaccine . Robbins et al (2003) Nuclear factor-κB translocation mediates double-stranded ribonucleic acid-induced NIT-1 beta-cell apoptosis and up-regulates caspase-12 and tumor necrosis factor-associated ligand (TRAIL). Endocrinology 144 4616 PMID: 12960048 . Rouas et al (2004) Poly(I:C) used for human dendritic cell maturation preserves their ability to secondarily secrete bioactive IL-12. Int.Immunol. 16 767 PMID: 15096480 . West et al (2011) TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472 476 PMID: 21525932 . Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554|Product information|CAS Number: 24939-03-5|Molecular Weight: 671.40|Formula: C19H27N7O16P2|Chemical Name: {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid; {[(2R,3S,4S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid|Smiles: NC1C=CN([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]2O)C(=O)N=1.OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1NC=NC2=O|InChiKey: ACEVNMQDUCOKHT-YJZUVTEISA-N|InChi: InChI=1S/C10H13N4O8P.C9H14N3O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7+,8-/m11/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
UK 1, an unusual bis-benzoxazole metabolite isolated from Streptomyces sp. 517-02, is an inhibitor of topoisomerase II (Topo II) and hepatitis C viral replication. It is an antifungal and an antibiotic, and displays a wide spectrum of potent anticancer activities against lymphoma, leukemia, and certain solid tumor-derived cell lines with IC50 values as low as 20 nM. However, UK 1 is devoid of antimicrobial activity and is inactive against Pseudomonas aeruginosa and Staphylococcus aureus, a methicillin-resistant strain of S. aureus. Additionally, UK-1 can bind a wide variety of di- and tri-valent metal ions, particularly Mg2+ ions, and form complexes with DNA in the presence of Mg2+ ions. Topo II are ATP-dependent enzymes, which can simultaneously cut both strands of the DNA helix to manage DNA supercoils and tangles. In vitro: UK 1 strongly blocked the growth of human epitheloid carcinoma HeLa, mouse melanoma B16, mouse leukemia P388 cells with ED50 values of 1.22 μg/ml, 1.17 μg/ml, and 0.{{Frexalimab} web|{Frexalimab} Apoptosis|{Frexalimab} Purity & Documentation|{Frexalimab} References|{Frexalimab} manufacturer|{Frexalimab} Epigenetic Reader Domain} 11 μg/ml, respectively.{{Tezepelumab (anti-TSLP)} site|{Tezepelumab (anti-TSLP)} Protocol|{Tezepelumab (anti-TSLP)} In Vitro|{Tezepelumab (anti-TSLP)} manufacturer|{Tezepelumab (anti-TSLP)} Autophagy} UK 1 did not display any growth inhibitory activity against bacteria, fungi and yeasts up to 100 μg/ml .PMID:23910527 In vivo: Up to now, in vivo study of UK 1 is still in the development stage.|Product information|CAS Number: 151271-53-3|Molecular Weight: 386.36|Formula: C22H14N2O5|Chemical Name: methyl 2-[2-(2-hydroxyphenyl)-1,3-benzoxazol-4-yl]-1,3-benzoxazole-4-carboxylate|Smiles: COC(=O)C1=CC=CC2OC(=NC=21)C1=CC=CC2OC(=NC=21)C1=CC=CC=C1O|InChiKey: NGKIDJMAXLRJRL-UHFFFAOYSA-N|InChi: InChI=1S/C22H14N2O5/c1-27-22(26)14-8-5-11-17-19(14)24-21(29-17)13-7-4-10-16-18(13)23-20(28-16)12-6-2-3-9-15(12)25/h2-11,25H,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
2,4-Diacetylphloroglucinol is an agent against various plant pathogenic fungi, viruses, bacteria, and nematodes. 2,4-Diacetylphloroglucinol, a non-nitrogen-containing compound produced by some isolates of P. fluorescens, has been used to increase crop yield by controlling plant root diseases. In vitro: A previous study was conducted to determine if 2,4-diacetylphloroglucinol was toxic to selected nematodes. The plant-parasitic nematodes including Pratylenchus scribneri and Xiphinema americanum, Heterodera glycines, Meloidogyne incognita, and the bacterial-feeding nematodes such as Pristionchus pacificus, Caenorhabditis elegans, and Rhabditis rainai, were found to be immersed in concentrations ranging from 0 to 100 μg/ml of 2,4-diacetylphloroglucinol. Moreove, the egg hatch and viability of juveniles and adults were determined, and the results showed that 2,4-diacetylphloroglucinol was toxic to X. americanum adults with an LD50 of 8.3 μg/ml. 2,4-Diacetylphloroglucinol could decrease M. incognita egg hatch, but stimulated C. elegans hatch. Whereas, the viability of M. incognita J2 and of C. elegans J1 and adults was not affected. There were no observed effects on the other nematodes. These findings indicated that 2,4-diacetylphloroglucinol was not toxic to all nematodes, and did not affect the tested species of beneficial bacterial-feeding nematodes . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 2161-86-6|Molecular Weight: 210.18|Formula: C10H10O5|Chemical Name: 1-(3-acetyl-2,4,6-trihydroxyphenyl)ethan-1-one|Smiles: CC(=O)C1C(O)=CC(O)=C(C=1O)C(C)=O|InChiKey: PIFFQYJYNWXNGE-UHFFFAOYSA-N|InChi: InChI=1S/C10H10O5/c1-4(11)8-6(13)3-7(14)9(5(2)12)10(8)15/h3,13-15H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
CGP 13501 is a positive allosteric modulator of GABAB receptor . The GABAB receptor is a metabotropic transmembrane receptors for GABA that is linked via G-protein to potassium channel.{{Nicorandil} web|{Nicorandil} Potassium Channel|{Nicorandil} Technical Information|{Nicorandil} In Vitro|{Nicorandil} supplier|{Nicorandil} Autophagy} It stimulates the opening of K+ channel and hyperpolarize the neuron.PMID:23539298 CGP 13501 is a positive allosteric modulator of GABAB receptor. In Chinese hamster ovary (CHO) cell line expressing GABAB(1b/2), CGP 13501 potentiated GABA-stimulated GTPγ[35S] binding to cell membranes . In rat cortex, CGP13501 (10 μM) enhanced GABA-mediated activation of Gαo and increased GTPγ[35S] binding in the presence of GABA. Also, in the hippocampus and cerebellum, CGP13501 increased GABA-induced GTPγ[35S] binding and activation of Gαo. In rat cortex, hippocampus and cerebellum, CGP55845A blocked the influence of CGP13501 on GABA-induced GTPγ[35S] binding at Gαo with pIC50 values of 7.4, 7.31 and 6.82, respectively. In cells expressing GABAB(1b+2) receptors, CGP13501 increased GTPγ[35S] binding at Gαi1/3 .|Product information|CAS Number: 56189-68-5|Molecular Weight: 290.44|Formula: C19H30O2|Chemical Name: 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal|Smiles: CC(C)(C)C1=CC(CC(C)(C)C=O)=CC(=C1O)C(C)(C)C|InChiKey: XGWATTXMMMANFJ-UHFFFAOYSA-N|InChi: InChI=1S/C19H30O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,12,21H,11H2,1-8H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
3-Guanidinopropionic Acid is an AMP-activated protein kinase (AMPK) stimulator and PPARγ coactivator 1α (PGC-1α) activator.{{Fremanezumab} site|{Fremanezumab} Neuronal Signaling|{Fremanezumab} Biological Activity|{Fremanezumab} In stock|{Fremanezumab} supplier|{Fremanezumab} Epigenetics} AMP-activated protein kinase is an enzyme involved in cellular energy homeostasis.{{Abciximab} MedChemExpress|{Abciximab} Integrin|{Abciximab} Technical Information|{Abciximab} Purity|{Abciximab} custom synthesis|{Abciximab} Cancer} AMPK activation has been involved in stimulation of hepatic fatty acid oxidation, ketogenesis, skeletal muscle fatty acid oxidation and glucose uptake, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipolysis and lipogenesis, and modulation of insulin secretion by pancreatic beta-cells .PMID:23927631 PGC-1α is a transcriptional coactivator involved in regulating the genes implicated in energy metabolism and mitochondrial biogenesis, such as the the expression of AMPK, genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance . 3-Guanidinopropionic acid improved insulin sensitivity and promoted weight loss selectively from adipose tissue in animal models of non-insulin-dependent diabetes mellitus (NIDDM). 3-Guanidinopropionic acid was a substrate for both the creatine transporter and creatine kinase . In KKAy mice with noninsulin-dependent diabetes, 3-guanidinopropionic acid decreased the plasma glucose level. In insulin-resistant rhesus monkeys, 3-guanidinopropionic acid increased the disappearance of i.v. glucose .|Product information|CAS Number: 353-09-3|Molecular Weight: 131.13|Formula: C4H9N3O2|Chemical Name: 3-carbamimidamidopropanoic acid|Smiles: NC(=N)NCCC(O)=O|InChiKey: KMXXSJLYVJEBHI-UHFFFAOYSA-N|InChi: InChI=1S/C4H9N3O2/c5-4(6)7-2-1-3(8)9/h1-2H2,(H,8,9)(H4,5,6,7)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
2-hydroxyFlutamide is an androgen receptor (AR) inhibitor .{{Meropenem} medchemexpress|{Meropenem} Penicillin-binding protein (PBP)|{Meropenem} Biological Activity|{Meropenem} Purity|{Meropenem} manufacturer|{Meropenem} Autophagy} The androgen receptor has been implicated in the development and progression of prostate cancer.{{Vericiguat} MedChemExpress|{Vericiguat} GPCR/G Protein|{Vericiguat} Protocol|{Vericiguat} In stock|{Vericiguat} manufacturer|{Vericiguat} Epigenetics} AR is expressed in many androgen-independent or hormone refractory prostate cancers and is maintained throughout prostate cancer progression.PMID:23996047 Inactivation of AR may delay prostate cancer progression . 2-hydroxyFlutamide is the major metabolite of flutamide generated during the metabolism of the non-steroidal antiandrogen flutamide by CYP1A2 and CYP3A4. Flutamide is an antiandrogenic drug which has been widely used for treatment of prostate cancer. 2-hydroxyflutamide could inhibit flutamide metabolism. In cells, increased conversion of flutamide to 2-hydroxyflutamide or accumulation of 2-hydroxyflutamide may result in the anomalous responses to flutamide, which can be observed in some advanced prostate cancers . 2-hydroxy flutamide blocked the expression of AR target genes and prevented androgen-dependent stabilization of the AR . 2-hydroxyFlutamide was a more powerful antiandrogen in vivo, with higher binding affinity for the AR than flutamide. In humans, hydroxyflutamide exhibited an elimination halflife of about 8 h .|Product information|CAS Number: 52806-53-8|Molecular Weight: 292.21|Formula: C11H11F3N2O4|Chemical Name: 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide|Smiles: CC(C)(O)C(=O)NC1C=C(C(=CC=1)[N+]([O-])=O)C(F)(F)F|InChiKey: YPQLFJODEKMJEF-UHFFFAOYSA-N|InChi: InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 2113-05-5|Molecular Weight: 248.11|Formula: C8H11Cl2N5|Chemical Name: (E)-N”-(3-chlorophenyl)-N-(diaminomethylidene)guanidine hydrochloride|Smiles: Cl.NC(N)=N/C(/N)=N/C1C=C(Cl)C=CC=1|InChiKey: FOWAIJYHRWFTHR-UHFFFAOYSA-N|InChi: InChI=1S/C8H10ClN5.ClH/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11;/h1-4H,(H6,10,11,12,13,14);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Product information|CAS Number: 1245626-05-4|Molecular Weight: 556.46|Formula: C26H23Cl2N5O3S|Chemical Name: 5-[4-(4-cyanobut-1-yn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxo-1λ⁶-thiomorpholin-4-yl)-4-methyl-1H-pyrazole-3-carboxamide|Smiles: CC1C(=NN(C=1C1C=CC(=CC=1)C#CCCC#N)C1C=CC(Cl)=CC=1Cl)C(=O)NN1CCS(=O)(=O)CC1|InChiKey: XBHQLFVDGLPBCK-UHFFFAOYSA-N|InChi: InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Devazepide (L-364,718) is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders.{{Cetirizine} site|{Cetirizine} Histamine Receptor|{Cetirizine} Purity & Documentation|{Cetirizine} In Vivo|{Cetirizine} manufacturer|{Cetirizine} Epigenetics} |Product information|CAS Number: 103420-77-5|Molecular Weight: 408.{{Troglitazone} web|{Troglitazone} Autophagy|{Troglitazone} Technical Information|{Troglitazone} Formula|{Troglitazone} manufacturer|{Troglitazone} Cancer} 45|Formula: C25H20N4O2|Chemical Name: N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide|Smiles: CN1C2=CC=CC=C2C(=N[C@H](NC(=O)C2=CC3=CC=CC=C3N2)C1=O)C1C=CC=CC=1|InChiKey: NFHRQQKPEBFUJK-HSZRJFAPSA-N|InChi: InChI=1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 200 mg/mL (489.PMID:23543429 66 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Devazepide (oral gavage; 4 mg/kg; twice per day) significantly accelerates cholesterol crystallization and crystal growth to microlithiasis, and the formation of gallstones in mice. Devazepide (intraperitoneal injection; 0.1-1 mg/kg) has opposite effects on spontaneous locomotor activity, and on caerulein- and apomorphine-induced hypomotility in the mouse.|Products are for research use only. Not for human use.|

Additional information:
WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation.|Product information|CAS Number: 1354825-62-9|Molecular Weight: 415.49|Formula: C23H25N7O|Chemical Name: N-{2-[4-amino-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-2-methylpropyl}-3-methylpyridine-2-carboxamide|Smiles: CC1C=CC(=CC=1)C1=NN(C2=NC=NC(N)=C12)C(C)(C)CNC(=O)C1=NC=CC=C1C|InChiKey: ZCZGSEXBXXYQQC-UHFFFAOYSA-N|InChi: InChI=1S/C23H25N7O/c1-14-7-9-16(10-8-14)19-17-20(24)27-13-28-21(17)30(29-19)23(3,4)12-26-22(31)18-15(2)6-5-11-25-18/h5-11,13H,12H2,1-4H3,(H,26,31)(H2,24,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 30 mg/mL (72.20 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
5′-Guanylic acid disodium salt (5′-GMP disodium salt) is composed of guanine, ribose, and phosphate moieties and it is a nucleotide monomer in messenger RNA. Guanosine derivatives are involved in intracellular signal transduction and have been identified in repetitive genomic sequences in telomeres, in ribosomal DNA, immunoglobulin heavy‐chain switch regions, and in the control regions of proto-oncogenes.|Product information|CAS Number: 5550-12-9|Molecular Weight: 407.PMID:23789847 18|Formula: C10H12N5Na2O8P|Chemical Name: disodium [(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate|Smiles: [Na+].[Na+].NC1NC(=O)C2N=CN([C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C=2N=1|InChiKey: PVBRXXAAPNGWGE-LGVAUZIVSA-L|InChi: InChI=1S/C10H14N5O8P.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
2′-Deoxycytidine-5′-monophosphoric acid is an endogenous metabolite.PMID:23074147 |Product information|CAS Number: 1032-65-1|Molecular Weight: 307.20|Formula: C9H14N3O7P|Chemical Name: {[(2R,3S,5R)-3-hydroxy-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid|Smiles: N=C1C=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(O)=N1|InChiKey: NCMVOABPESMRCP-SHYZEUOFSA-N|InChi: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/t5-,6+,8+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Propineb (Zinc propylenebis) is a compound widely used in fruit and vegetables cultures, due to its large spectrum of activity against fungal plant diseases.{{Domperidone monomaleate} site|{Domperidone monomaleate} Neuronal Signaling|{Domperidone monomaleate} Biological Activity|{Domperidone monomaleate} Purity|{Domperidone monomaleate} supplier|{Domperidone monomaleate} Autophagy} |Product information|CAS Number: 12071-83-9|Molecular Weight: 289.{{Golidocitinib} medchemexpress|{Golidocitinib} JAK/STAT Signaling|{Golidocitinib} Protocol|{Golidocitinib} In Vivo|{Golidocitinib} custom synthesis|{Golidocitinib} Autophagy} 80|Formula: C5H8N2S4Zn|Chemical Name: zinc(2+) ({1-[(sulfanidylmethanethioyl)amino]propan-2-yl}carbamothioyl)sulfanide|Smiles: [Zn+2].PMID:24455443 CC(CNC([S-])=S)NC([S-])=S|InChiKey: KKMLIVYBGSAJPM-UHFFFAOYSA-L|InChi: InChI=1S/C5H10N2S4.Zn/c1-3(7-5(10)11)2-6-4(8)9;/h3H,2H2,1H3,(H2,6,8,9)(H2,7,10,11);/q;+2/p-2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (115.02 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Propineb (Zinc propylenebis) has a moderate to low acute toxicity with a specific goitrogenic effect in rats. long-term exposure, oral or by inhalation is related to carcinogenicity, teratogenicity, malfunction of the reproductive system and malformation of their vitals.|Products are for research use only. Not for human use.|

Additional information:
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.{{Lasalocid} web|{Lasalocid} Autophagy|{Lasalocid} Protocol|{Lasalocid} Purity|{Lasalocid} manufacturer|{Lasalocid} Epigenetics} |Product information|CAS Number: 1351927-00-8|Molecular Weight: 327.{{Tebuconazole} site|{Tebuconazole} Cytochrome P450|{Tebuconazole} Protocol|{Tebuconazole} In Vivo|{Tebuconazole} custom synthesis|{Tebuconazole} Autophagy} 36|Formula: C17H18FN5O|Chemical Name: 1-(3-{[4-amino-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl}phenyl)-2-fluoroethan-1-one|Smiles: CC(C)N1N=C(CC2=CC(=CC=C2)C(=O)CF)C2=C(N)N=CN=C12|InChiKey: WEPKWIAJJGCTLW-UHFFFAOYSA-N|InChi: InChI=1S/C17H18FN5O/c1-10(2)23-17-15(16(19)20-9-21-17)13(22-23)7-11-4-3-5-12(6-11)14(24)8-18/h3-6,9-10H,7-8H2,1-2H3,(H2,19,20,21)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35116795 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
EGLU ((2S)-α-Ethylglutamic acid; (2S)-α-EGLU) is a potent and competitive mGluR-2 receptor antagonist. EGLU interacts with (lS,3S)-ACPD-sensitive site with a Kd value of 66 μM. EGLU is an antidepressant agent.|Product information|CAS Number: 170984-72-2|Molecular Weight: 175.18|Formula: C7H13NO4|Chemical Name: (2S)-2-amino-2-ethylpentanedioic acid|Smiles: CC[C@](N)(CCC(O)=O)C(O)=O|InChiKey: QFYBYZLHPIALCZ-ZETCQYMHSA-N|InChi: InChI=1S/C7H13NO4/c1-2-7(8,6(11)12)4-3-5(9)10/h2-4,8H2,1H3,(H,9,10)(H,11,12)/t7-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EGLU (200 μM) selectively antagonizes (lS,3S)-ACPD-induced depressions of the monosynaptic component of the DRVRP, displaying little or no antagonist activity versus L-AP6 induced depressions or on the DRVRP alone.|Products are for research use only. Not for human use.|

Additional information:
Cefamandole Sodium Salt is a second-generation broad-spectrum cephalosporin antibiotic.|Product information|CAS Number: 30034-03-8|Molecular Weight: 484.{{Ketoconazole} site|{Ketoconazole} Anti-infection|{Ketoconazole} Protocol|{Ketoconazole} References|{Ketoconazole} manufacturer|{Ketoconazole} Autophagy} 48|Formula: C18H17N6NaO5S2|Chemical Name: sodium (6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.{{Tirofiban} MedChemExpress|{Tirofiban} Integrin|{Tirofiban} Technical Information|{Tirofiban} References|{Tirofiban} manufacturer|{Tirofiban} Cancer} 2.PMID:23865629 0]oct-2-ene-2-carboxylate|Smiles: [Na+].CN1N=NN=C1SCC1CS[C@@H]2[C@H](NC(=O)[C@H](O)C3=CC=CC=C3)C(=O)N2C=1C([O-])=O|InChiKey: OJMNTWPPFNMOCJ-CFOLLTDRSA-M|InChi: InChI=1S/C18H18N6O5S2.Na/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9;/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29);/q;+1/p-1/t11-,13-,16-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (103.20 mM; Need ultrasonic). H2O : 33.33 mg/mL (68.80 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Arctiin is a lignan found in many plants of the Asteraceae family, particularly the greater burdock (Arctium lappa) and Centaurea imperialis, and in Trachelospermum asiaticum, Saussurea heteromalla.{{Trastuzumab (anti-HER2)} medchemexpress|{Trastuzumab (anti-HER2)} JAK/STAT Signaling|{Trastuzumab (anti-HER2)} NF-κB|{Trastuzumab (anti-HER2)} Biological Activity|{Trastuzumab (anti-HER2)} Formula|{Trastuzumab (anti-HER2)} supplier} , and Forsythia viridissima. It is the glucoside of arctigenin. Arctiin and arctigenin have shown anticancer effects.|Product information|CAS Number: 20362-31-6|Molecular Weight: 534.55|Formula: C27H34O11|Chemical Name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-methoxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)methyl]oxolan-2-one|Smiles: COC1=CC=C(C[C@H]2COC(=O)[C@@H]2CC2=CC(OC)=C(C=C2)O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1OC|InChiKey: XOJVHLIYNSOZOO-SWOBOCGESA-N|InChi: InChI=1S/C27H34O11/c1-33-18-6-4-14(10-20(18)34-2)8-16-13-36-26(32)17(16)9-15-5-7-19(21(11-15)35-3)37-27-25(31)24(30)23(29)22(12-28)38-27/h4-7,10-11,16-17,22-25,27-31H,8-9,12-13H2,1-3H3/t16-,17+,22+,23+,24-,25+,27+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24487575 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
TIC10 isomer is an isomer and the “inactive version” of TIC10. TIC-10 isomer was introduced to the research community since it was structurally wrong-assigned as the bioactive TIC-10 during early stage development of TIC-10 (now called ONC-201).{{Atropine} medchemexpress|{Atropine} Metabolic Enzyme/Protease|{Atropine} Technical Information|{Atropine} Description|{Atropine} supplier|{Atropine} Epigenetic Reader Domain} TIC-10 isomer was found to be inactive, which did not reduce the viability of cancer cells.PMID:23291014 TIC-10 isomer may be used as a reference compound to compare with ONC-201.|Product information|CAS Number: 41276-02-2|Molecular Weight: 386.49|Formula: C24H26N4O|Chemical Name: 11-benzyl-2-[(2-methylphenyl)methyl]-2,4,7,11-tetraazatricyclo[7.4.0.0³,⁷]trideca-1(9),3-dien-8-one|Smiles: CC1=CC=CC=C1CN1C2=NCCN2C(=O)C2CN(CC3C=CC=CC=3)CCC1=2|InChiKey: RSAQARAFWMUYLL-UHFFFAOYSA-N|InChi: InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-22-11-13-26(15-19-8-3-2-4-9-19)17-21(22)23(29)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
c-Met inhibitor 1 is an inhibitor of the c-Met receptor signaling pathway useful for the treatment of cancer including gastric, glioblastoma, and pancreatic cancer. IC50 value:Target: c-MetMore details please refer to Patent WO 2012015677 A1.|Product information|CAS Number: 1357072-61-7|Molecular Weight: 362.41|Formula: C17H14N8S|Chemical Name: 2-methyl-5-{[6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-2H-indazole|Smiles: CN1C=C2C=C(C=CC2=N1)SC1=NN=C2C=CC(=NN21)C1C=NN(C)C=1|InChiKey: JYXHZDNTBJUJNH-UHFFFAOYSA-N|InChi: InChI=1S/C17H14N8S/c1-23-10-12(8-18-23)15-5-6-16-19-20-17(25(16)22-15)26-13-3-4-14-11(7-13)9-24(2)21-14/h3-10H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Xevinapant} MedChemExpress|{Xevinapant} IAP|{Xevinapant} Purity & Documentation|{Xevinapant} Formula|{Xevinapant} custom synthesis|{Xevinapant} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.PMID:35850484 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Dasabuvir, also known as ABT-333, is a non-nucleoside polymerase inhibitor currently under clinical trials for the treatment of Hepatitis C. In the United States, it is approved by the Food and Drug Administration for use in combination with ombitasvir, paritaprevir, and ritonavir in the product Viekira Pak. Dasabuvir acts as a NS5B (an RNA-directed RNA polymerase) inhibitor.|Product information|CAS Number: 1132935-63-7|Molecular Weight: 493.57|Formula: C26H27N3O5S|Synonym:|Dasabuvir|ABT333|ABT 333|Chemical Name: N-{6-[3-tert-butyl-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl}methanesulfonamide|Smiles: COC1C(=CC(=CC=1C(C)(C)C)N1C=CC(=O)NC1=O)C1=CC2=CC=C(C=C2C=C1)NS(C)(=O)=O|InChiKey: NBRBXGKOEOGLOI-UHFFFAOYSA-N|InChi: InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ABT-333 (Dasabuvir) is at least 7, 000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases. ABT-333 (Dasabuvir) inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM. ABT-333 inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.{{OPC 4392} site|{OPC 4392} Dopamine Receptor|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} In Vivo|{OPC 4392} supplier} 7 and 1.{{Mecillinam} medchemexpress|{Mecillinam} Antibiotic|{Mecillinam} Epigenetics|{Mecillinam} Protocol|{Mecillinam} References|{Mecillinam} supplier} 8 nM against genotype 1a (H77) and 1b (Con1), respectively.PMID:23756629 In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively.|In Vivo:|The recombinant HCV polymerases used in this study contain the first 570 amino acids of the 591-amino acid native protein sequence, with a six-histidine tag at the N terminus to facilitate purification by affinity chromatography. Briefly, ABT-333 (Dasabuvir) is incubated with 5 to 50 nM polymerase for 15 min at room temperature, follow by the addition of nucleoside triphosphates (NTPs) and [3H]UTP for 3 h at 30°C. After termination of the reaction, the precipitated RNA is captured by filtration through a GF/B filter. The amount of incorporated [3H]UTP is measured by scintillation counting with a Wallac 1450 MicroBeta counter. The percent inhibition is calculated from the initial rates of inhibited reactions relative to that of the uninhibited control reaction. The mean 50% inhibitory concentration (IC50) and the standard error of the mean (SEM) are calculated via nonlinear regression.|References:|Kati W, et al. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2015 Mar;59(3):1505-11.Products are for research use only. Not for human use.|

Additional information:
Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Enoxacin is a broad-spectrum antibacterial agent that is structurally related to nalidixic acid. It acts on DNA gyrase.{{Baclofen} medchemexpress|{Baclofen} Membrane Transporter/Ion Channel|{Baclofen} Protocol|{Baclofen} In stock|{Baclofen} manufacturer|{Baclofen} Epigenetics} Insomnia is a common adverse effect. Recently, enoxacin has been shown recently that it may have cancer inhibiting effect.|Product information|CAS Number: 74011-58-8|Molecular Weight: 320.32|Formula: C15H17FN4O3|Synonym:|Penetrex|AT 2266|CI 919|Chemical Name: 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid|Smiles: CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N=C12)N1CCNCC1|InChiKey: IDYZIJYBMGIQMJ-UHFFFAOYSA-N|InChi: InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{OPC 4392} site|{OPC 4392} GPCR/G Protein|{OPC 4392} TGF-beta/Smad|{OPC 4392} Protocol|{OPC 4392} Purity|{OPC 4392} supplier} |Shelf Life: ≥12 months if stored properly.PMID:23291014 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.|Product information|CAS Number: 2222768-84-3|Molecular Weight: 431.50|Formula: C22H23F2N3O2S|Chemical Name: ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate|Smiles: CCOC(=O)C1SC(NC2=CC=C(F)C=C2F)=NC=1C1C=CC(=CC=1)N(CC)CC|InChiKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|